Betacellulin in Chronic Periodontitis Patients With and Without Type 2 Diabetes Mellitus: An Immunohistochemical Study
Background: The host immune response to bacterial dental plaque determines periodontal disease susceptibility by increasing the secretion of inflammatory cytokines. The Epidermal Growth Factor family cytokines stimulate proliferation and keratinization of cells in dermis and oral epithelium. Epi...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2015-11-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/6725/15275_CE(RA1)_F(T)_PF1(PAK)_PFA(AK)_PF2(PAG).pdf |
| Summary: | Background: The host immune response to bacterial dental
plaque determines periodontal disease susceptibility by increasing
the secretion of inflammatory cytokines. The Epidermal Growth
Factor family cytokines stimulate proliferation and keratinization
of cells in dermis and oral epithelium. Epidermal Growth Factor
family consists of Amphiregulin, Betacellulin, Epiregulin, Epigen,
Heparin binding Epidermal Growth Factor like growth factor and
transforming Growth Factor-alpha.
Aim: The current study aimed to investigate expression of
Betacellulin in chronic periodontitis patients with and without type
2 diabetes mellitus and thereby assessing role of betacellulin in
periodontal health and disease.
Materials and Methods: Present study comprised of 90
participants, age ranges from 18 to 60-year-old, for the period of
March 2010 to May 2011. Participants were categorized into three
groups based Gingival index (GI), probing depth (PD) and clinical
attachment loss (CA Loss). Group 1 consisted 30 individuals with
clinically healthy periodontium, Group-2 consisted 30 individuals
with GI>1, PD≥5 mm, and CA Loss>3 mm. Group-3 (Chronic
Periodontitis with type 2 diabetes mellitus) consisted 30 with
GI >1, PD≥5 mm, and CA Loss>3 mm. Immunohistochemical
localization and quantification of Betacellulin was done in gingival
tissue samples from all groups.
Results: Data showed expression of Betacellulin were higher in
chronic periodontitis as compared to healthy. A positive correlation
found in Betacellulin expression and Probing Depth in chronic
periodontitis.
Conclusion: This footmark study impacts the role of Betacellulin
in pathogenesis and progression of periodontal disease which
will help in exploration of novel immunotherapeutic strategies and
immunological research activity in this field. |
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| ISSN: | 2249-782X 0973-709X |