Betacellulin in Chronic Periodontitis Patients With and Without Type 2 Diabetes Mellitus: An Immunohistochemical Study
Background: The host immune response to bacterial dental plaque determines periodontal disease susceptibility by increasing the secretion of inflammatory cytokines. The Epidermal Growth Factor family cytokines stimulate proliferation and keratinization of cells in dermis and oral epithelium. Epi...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2015-11-01
|
| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/6725/15275_CE(RA1)_F(T)_PF1(PAK)_PFA(AK)_PF2(PAG).pdf |
| _version_ | 1818455311103557632 |
|---|---|
| author | Gauri M Ugale Nagaraj B. Kalburgi Shivaprasad Bilichodmath Shivaraj B. Warad Mahesh S. Ugale Arati C. Koregol Shobha C. Bijjargi |
| author_facet | Gauri M Ugale Nagaraj B. Kalburgi Shivaprasad Bilichodmath Shivaraj B. Warad Mahesh S. Ugale Arati C. Koregol Shobha C. Bijjargi |
| author_sort | Gauri M Ugale |
| collection | DOAJ |
| description | Background: The host immune response to bacterial dental
plaque determines periodontal disease susceptibility by increasing
the secretion of inflammatory cytokines. The Epidermal Growth
Factor family cytokines stimulate proliferation and keratinization
of cells in dermis and oral epithelium. Epidermal Growth Factor
family consists of Amphiregulin, Betacellulin, Epiregulin, Epigen,
Heparin binding Epidermal Growth Factor like growth factor and
transforming Growth Factor-alpha.
Aim: The current study aimed to investigate expression of
Betacellulin in chronic periodontitis patients with and without type
2 diabetes mellitus and thereby assessing role of betacellulin in
periodontal health and disease.
Materials and Methods: Present study comprised of 90
participants, age ranges from 18 to 60-year-old, for the period of
March 2010 to May 2011. Participants were categorized into three
groups based Gingival index (GI), probing depth (PD) and clinical
attachment loss (CA Loss). Group 1 consisted 30 individuals with
clinically healthy periodontium, Group-2 consisted 30 individuals
with GI>1, PD≥5 mm, and CA Loss>3 mm. Group-3 (Chronic
Periodontitis with type 2 diabetes mellitus) consisted 30 with
GI >1, PD≥5 mm, and CA Loss>3 mm. Immunohistochemical
localization and quantification of Betacellulin was done in gingival
tissue samples from all groups.
Results: Data showed expression of Betacellulin were higher in
chronic periodontitis as compared to healthy. A positive correlation
found in Betacellulin expression and Probing Depth in chronic
periodontitis.
Conclusion: This footmark study impacts the role of Betacellulin
in pathogenesis and progression of periodontal disease which
will help in exploration of novel immunotherapeutic strategies and
immunological research activity in this field. |
| first_indexed | 2024-12-14T22:08:45Z |
| format | Article |
| id | doaj.art-3e8868ae0d984ccb9414683cc7f23466 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-14T22:08:45Z |
| publishDate | 2015-11-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-3e8868ae0d984ccb9414683cc7f234662022-12-21T22:45:49ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2015-11-01911ZC05ZC0910.7860/JCDR/2015/15275.6725Betacellulin in Chronic Periodontitis Patients With and Without Type 2 Diabetes Mellitus: An Immunohistochemical StudyGauri M Ugale0Nagaraj B. Kalburgi1Shivaprasad Bilichodmath2Shivaraj B. Warad3Mahesh S. Ugale4Arati C. Koregol5Shobha C. Bijjargi6Assistant Professor, Department of Periodontics, MIDSR Dental College and Hospital, Latur, Maharashtra, India.Professor, Department of Periodontics, PMNM Dental Collegeand Hospital, Bagalkot, Karnataka, India.Associate Professor, Department of Periodontics, Rajarajeshwari Dental College, Bangalore, karnataka, India.Professor, Department of Periodontics, P.M.N.M Dental College and Hospital, Bagalkot, Karnataka, India.Professor, Department of Anatomy, MIMSR Medical College, Latur, Maharashtra, India.Reader, Department of Periodontics, P.M.N.M Dental College and Hospital, Bagalkot, Karnataka, India.Lecturer, Department of Oral Medicine & Radiology, MIDSR Dental College, Latur, Maharashtra, India.Background: The host immune response to bacterial dental plaque determines periodontal disease susceptibility by increasing the secretion of inflammatory cytokines. The Epidermal Growth Factor family cytokines stimulate proliferation and keratinization of cells in dermis and oral epithelium. Epidermal Growth Factor family consists of Amphiregulin, Betacellulin, Epiregulin, Epigen, Heparin binding Epidermal Growth Factor like growth factor and transforming Growth Factor-alpha. Aim: The current study aimed to investigate expression of Betacellulin in chronic periodontitis patients with and without type 2 diabetes mellitus and thereby assessing role of betacellulin in periodontal health and disease. Materials and Methods: Present study comprised of 90 participants, age ranges from 18 to 60-year-old, for the period of March 2010 to May 2011. Participants were categorized into three groups based Gingival index (GI), probing depth (PD) and clinical attachment loss (CA Loss). Group 1 consisted 30 individuals with clinically healthy periodontium, Group-2 consisted 30 individuals with GI>1, PD≥5 mm, and CA Loss>3 mm. Group-3 (Chronic Periodontitis with type 2 diabetes mellitus) consisted 30 with GI >1, PD≥5 mm, and CA Loss>3 mm. Immunohistochemical localization and quantification of Betacellulin was done in gingival tissue samples from all groups. Results: Data showed expression of Betacellulin were higher in chronic periodontitis as compared to healthy. A positive correlation found in Betacellulin expression and Probing Depth in chronic periodontitis. Conclusion: This footmark study impacts the role of Betacellulin in pathogenesis and progression of periodontal disease which will help in exploration of novel immunotherapeutic strategies and immunological research activity in this field.https://jcdr.net/articles/PDF/6725/15275_CE(RA1)_F(T)_PF1(PAK)_PFA(AK)_PF2(PAG).pdfepidermal growth factormatrix metalloproteinase-9 |
| spellingShingle | Gauri M Ugale Nagaraj B. Kalburgi Shivaprasad Bilichodmath Shivaraj B. Warad Mahesh S. Ugale Arati C. Koregol Shobha C. Bijjargi Betacellulin in Chronic Periodontitis Patients With and Without Type 2 Diabetes Mellitus: An Immunohistochemical Study Journal of Clinical and Diagnostic Research epidermal growth factor matrix metalloproteinase-9 |
| title | Betacellulin in Chronic Periodontitis Patients With and Without Type 2 Diabetes Mellitus: An Immunohistochemical Study |
| title_full | Betacellulin in Chronic Periodontitis Patients With and Without Type 2 Diabetes Mellitus: An Immunohistochemical Study |
| title_fullStr | Betacellulin in Chronic Periodontitis Patients With and Without Type 2 Diabetes Mellitus: An Immunohistochemical Study |
| title_full_unstemmed | Betacellulin in Chronic Periodontitis Patients With and Without Type 2 Diabetes Mellitus: An Immunohistochemical Study |
| title_short | Betacellulin in Chronic Periodontitis Patients With and Without Type 2 Diabetes Mellitus: An Immunohistochemical Study |
| title_sort | betacellulin in chronic periodontitis patients with and without type 2 diabetes mellitus an immunohistochemical study |
| topic | epidermal growth factor matrix metalloproteinase-9 |
| url | https://jcdr.net/articles/PDF/6725/15275_CE(RA1)_F(T)_PF1(PAK)_PFA(AK)_PF2(PAG).pdf |
| work_keys_str_mv | AT gaurimugale betacellulininchronicperiodontitispatientswithandwithouttype2diabetesmellitusanimmunohistochemicalstudy AT nagarajbkalburgi betacellulininchronicperiodontitispatientswithandwithouttype2diabetesmellitusanimmunohistochemicalstudy AT shivaprasadbilichodmath betacellulininchronicperiodontitispatientswithandwithouttype2diabetesmellitusanimmunohistochemicalstudy AT shivarajbwarad betacellulininchronicperiodontitispatientswithandwithouttype2diabetesmellitusanimmunohistochemicalstudy AT maheshsugale betacellulininchronicperiodontitispatientswithandwithouttype2diabetesmellitusanimmunohistochemicalstudy AT aratickoregol betacellulininchronicperiodontitispatientswithandwithouttype2diabetesmellitusanimmunohistochemicalstudy AT shobhacbijjargi betacellulininchronicperiodontitispatientswithandwithouttype2diabetesmellitusanimmunohistochemicalstudy |