ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway
Damaged mitochondria are known to cause neuronal death, suggesting clearance as a potential therapy. Here, Moskal et al. show that ROCK inhibitors promote Parkin recruitment and mitophagy and have neuroprotective effects in fruit flies challenged with a toxin that induces mitochondrial damage.
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-13781-3 |
| _version_ | 1818857712327327744 |
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| author | Natalia Moskal Victoria Riccio Mikhail Bashkurov Rediet Taddese Alessandro Datti Peter N. Lewis G. Angus McQuibban |
| author_facet | Natalia Moskal Victoria Riccio Mikhail Bashkurov Rediet Taddese Alessandro Datti Peter N. Lewis G. Angus McQuibban |
| author_sort | Natalia Moskal |
| collection | DOAJ |
| description | Damaged mitochondria are known to cause neuronal death, suggesting clearance as a potential therapy. Here, Moskal et al. show that ROCK inhibitors promote Parkin recruitment and mitophagy and have neuroprotective effects in fruit flies challenged with a toxin that induces mitochondrial damage. |
| first_indexed | 2024-12-19T08:44:45Z |
| format | Article |
| id | doaj.art-3e89b2ca7aa044dba87795668f0519b1 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T08:44:45Z |
| publishDate | 2020-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-3e89b2ca7aa044dba87795668f0519b12022-12-21T20:28:49ZengNature PortfolioNature Communications2041-17232020-01-0111111410.1038/s41467-019-13781-3ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathwayNatalia Moskal0Victoria Riccio1Mikhail Bashkurov2Rediet Taddese3Alessandro Datti4Peter N. Lewis5G. Angus McQuibban6Department of Biochemistry, University of TorontoDepartment of Biochemistry, University of TorontoNetwork Biology Collaborative Centre, Mount Sinai HospitalDepartment of Biochemistry, University of TorontoNetwork Biology Collaborative Centre, Mount Sinai HospitalDepartment of Biochemistry, University of TorontoDepartment of Biochemistry, University of TorontoDamaged mitochondria are known to cause neuronal death, suggesting clearance as a potential therapy. Here, Moskal et al. show that ROCK inhibitors promote Parkin recruitment and mitophagy and have neuroprotective effects in fruit flies challenged with a toxin that induces mitochondrial damage.https://doi.org/10.1038/s41467-019-13781-3 |
| spellingShingle | Natalia Moskal Victoria Riccio Mikhail Bashkurov Rediet Taddese Alessandro Datti Peter N. Lewis G. Angus McQuibban ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway Nature Communications |
| title | ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway |
| title_full | ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway |
| title_fullStr | ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway |
| title_full_unstemmed | ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway |
| title_short | ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway |
| title_sort | rock inhibitors upregulate the neuroprotective parkin mediated mitophagy pathway |
| url | https://doi.org/10.1038/s41467-019-13781-3 |
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