Extraction, Modification and Biomedical Application of Agarose Hydrogels: A Review
Numerous compounds present in the ocean are contributing to the development of the biomedical field. Agarose, a polysaccharide derived from marine red algae, plays a vital role in biomedical applications because of its reversible temperature-sensitive gelling behavior, excellent mechanical propertie...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/21/5/299 |
| _version_ | 1797599290418266112 |
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| author | Feng Jiang Xin-Wei Xu Fu-Quan Chen Hui-Fen Weng Jun Chen Yi Ru Qiong Xiao An-Feng Xiao |
| author_facet | Feng Jiang Xin-Wei Xu Fu-Quan Chen Hui-Fen Weng Jun Chen Yi Ru Qiong Xiao An-Feng Xiao |
| author_sort | Feng Jiang |
| collection | DOAJ |
| description | Numerous compounds present in the ocean are contributing to the development of the biomedical field. Agarose, a polysaccharide derived from marine red algae, plays a vital role in biomedical applications because of its reversible temperature-sensitive gelling behavior, excellent mechanical properties, and high biological activity. Natural agarose hydrogel has a single structural composition that prevents it from adapting to complex biological environments. Therefore, agarose can be developed into different forms through physical, biological, and chemical modifications, enabling it to perform optimally in different environments. Agarose biomaterials are being increasingly used for isolation, purification, drug delivery, and tissue engineering, but most are still far from clinical approval. This review classifies and discusses the preparation, modification, and biomedical applications of agarose, focusing on its applications in isolation and purification, wound dressings, drug delivery, tissue engineering, and 3D printing. In addition, it attempts to address the opportunities and challenges associated with the future development of agarose-based biomaterials in the biomedical field. It should help to rationalize the selection of the most suitable functionalized agarose hydrogels for specific applications in the biomedical industry. |
| first_indexed | 2024-03-11T03:33:12Z |
| format | Article |
| id | doaj.art-3e89ff4f2e4f4b8abe546a47cdaa87e1 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-11T03:33:12Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-3e89ff4f2e4f4b8abe546a47cdaa87e12023-11-18T02:13:06ZengMDPI AGMarine Drugs1660-33972023-05-0121529910.3390/md21050299Extraction, Modification and Biomedical Application of Agarose Hydrogels: A ReviewFeng Jiang0Xin-Wei Xu1Fu-Quan Chen2Hui-Fen Weng3Jun Chen4Yi Ru5Qiong Xiao6An-Feng Xiao7College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, ChinaCollege of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, ChinaCollege of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, ChinaCollege of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, ChinaCollege of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, ChinaCollege of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, ChinaCollege of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, ChinaCollege of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, ChinaNumerous compounds present in the ocean are contributing to the development of the biomedical field. Agarose, a polysaccharide derived from marine red algae, plays a vital role in biomedical applications because of its reversible temperature-sensitive gelling behavior, excellent mechanical properties, and high biological activity. Natural agarose hydrogel has a single structural composition that prevents it from adapting to complex biological environments. Therefore, agarose can be developed into different forms through physical, biological, and chemical modifications, enabling it to perform optimally in different environments. Agarose biomaterials are being increasingly used for isolation, purification, drug delivery, and tissue engineering, but most are still far from clinical approval. This review classifies and discusses the preparation, modification, and biomedical applications of agarose, focusing on its applications in isolation and purification, wound dressings, drug delivery, tissue engineering, and 3D printing. In addition, it attempts to address the opportunities and challenges associated with the future development of agarose-based biomaterials in the biomedical field. It should help to rationalize the selection of the most suitable functionalized agarose hydrogels for specific applications in the biomedical industry.https://www.mdpi.com/1660-3397/21/5/299agarosemodificationhydrogelbiomedical application |
| spellingShingle | Feng Jiang Xin-Wei Xu Fu-Quan Chen Hui-Fen Weng Jun Chen Yi Ru Qiong Xiao An-Feng Xiao Extraction, Modification and Biomedical Application of Agarose Hydrogels: A Review Marine Drugs agarose modification hydrogel biomedical application |
| title | Extraction, Modification and Biomedical Application of Agarose Hydrogels: A Review |
| title_full | Extraction, Modification and Biomedical Application of Agarose Hydrogels: A Review |
| title_fullStr | Extraction, Modification and Biomedical Application of Agarose Hydrogels: A Review |
| title_full_unstemmed | Extraction, Modification and Biomedical Application of Agarose Hydrogels: A Review |
| title_short | Extraction, Modification and Biomedical Application of Agarose Hydrogels: A Review |
| title_sort | extraction modification and biomedical application of agarose hydrogels a review |
| topic | agarose modification hydrogel biomedical application |
| url | https://www.mdpi.com/1660-3397/21/5/299 |
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