Gene polymorphisms in association with self-reported stroke in US adults
Amy Z Fan1, Jing Fang1, Ajay Yesupriya2, Man-huei Chang2, Greta Kilmer1, Meaghan House3, Donald Hayes1, Renée M Ned2, Nicole F Dowling2, Ali H Mokdad1 1National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA; 2O...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2010-03-01
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| Series: | The Application of Clinical Genetics |
| Online Access: | http://www.dovepress.com/gene-polymorphisms-in-association-with-self-reported-stroke-in-us-adul-a4072 |
| _version_ | 1811283055604662272 |
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| author | Amy Z Fan Jing Fang Ajay Yesupriya et al |
| author_facet | Amy Z Fan Jing Fang Ajay Yesupriya et al |
| author_sort | Amy Z Fan |
| collection | DOAJ |
| description | Amy Z Fan1, Jing Fang1, Ajay Yesupriya2, Man-huei Chang2, Greta Kilmer1, Meaghan House3, Donald Hayes1, Renée M Ned2, Nicole F Dowling2, Ali H Mokdad1 1National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA; 2Office of Public Health Genomics, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA; 3School of Public Health, Emory University, Atlanta, GA, USAPurpose: Epidemiologic studies suggest that several gene variants increase the risk of stroke, and population-based studies help provide further evidence. We identified polymorphisms associated with the prevalence of self-reported stroke in US populations using a representative sample.Methods: Our sample comprised US adults in the Third National Health and Nutrition Examination (NHANES III) DNA bank. We examined nine candidate gene variants within ACE, F2, F5, ITGA2, MTHFR, and NOS3 for associations with self-reported stroke. We used multivariate regression and Cox proportional hazards models to test the association between these variants and history of stroke.Results: In regression models, the rs4646994 variant of ACE (I/I and I/D genotypes) was associated with higher prevalence adjusted prevalence odds ratio [APOR] = 2.66 [1.28, 5.55] and 2.23 [1.30, 3.85], respectively) compared with the D/D genotype. The heterozygous genotype of MTHFR rs1801131 (A/C) was associated with lower prevalence of stroke (APOR = 0.48 [0.25, 0.92]) compared with A/A and C/C genotypes. For rs2070744 of NOS3, both the C/T genotype (APOR = 1.91 [1.12, 3.27]) and C/C genotype (APOR = 3.31 [1.66, 6.60]) were associated with higher prevalence of stroke compared with the T/T genotype.Conclusion: Our findings suggest an association between the prevalence of self-reported stroke and polymorphisms in ACE, MTHFR, and NOS3 in a population-based sample. Keywords: stroke, gene, polymorphisms, NHANES III, gene association analysis |
| first_indexed | 2024-04-13T02:04:45Z |
| format | Article |
| id | doaj.art-3e8d2b3f23b4472c86cab3dee320cc75 |
| institution | Directory Open Access Journal |
| issn | 1178-704X |
| language | English |
| last_indexed | 2024-04-13T02:04:45Z |
| publishDate | 2010-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | The Application of Clinical Genetics |
| spelling | doaj.art-3e8d2b3f23b4472c86cab3dee320cc752022-12-22T03:07:30ZengDove Medical PressThe Application of Clinical Genetics1178-704X2010-03-012010default2328Gene polymorphisms in association with self-reported stroke in US adultsAmy Z FanJing FangAjay Yesupriyaet alAmy Z Fan1, Jing Fang1, Ajay Yesupriya2, Man-huei Chang2, Greta Kilmer1, Meaghan House3, Donald Hayes1, Renée M Ned2, Nicole F Dowling2, Ali H Mokdad1 1National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA; 2Office of Public Health Genomics, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA; 3School of Public Health, Emory University, Atlanta, GA, USAPurpose: Epidemiologic studies suggest that several gene variants increase the risk of stroke, and population-based studies help provide further evidence. We identified polymorphisms associated with the prevalence of self-reported stroke in US populations using a representative sample.Methods: Our sample comprised US adults in the Third National Health and Nutrition Examination (NHANES III) DNA bank. We examined nine candidate gene variants within ACE, F2, F5, ITGA2, MTHFR, and NOS3 for associations with self-reported stroke. We used multivariate regression and Cox proportional hazards models to test the association between these variants and history of stroke.Results: In regression models, the rs4646994 variant of ACE (I/I and I/D genotypes) was associated with higher prevalence adjusted prevalence odds ratio [APOR] = 2.66 [1.28, 5.55] and 2.23 [1.30, 3.85], respectively) compared with the D/D genotype. The heterozygous genotype of MTHFR rs1801131 (A/C) was associated with lower prevalence of stroke (APOR = 0.48 [0.25, 0.92]) compared with A/A and C/C genotypes. For rs2070744 of NOS3, both the C/T genotype (APOR = 1.91 [1.12, 3.27]) and C/C genotype (APOR = 3.31 [1.66, 6.60]) were associated with higher prevalence of stroke compared with the T/T genotype.Conclusion: Our findings suggest an association between the prevalence of self-reported stroke and polymorphisms in ACE, MTHFR, and NOS3 in a population-based sample. Keywords: stroke, gene, polymorphisms, NHANES III, gene association analysishttp://www.dovepress.com/gene-polymorphisms-in-association-with-self-reported-stroke-in-us-adul-a4072 |
| spellingShingle | Amy Z Fan Jing Fang Ajay Yesupriya et al Gene polymorphisms in association with self-reported stroke in US adults The Application of Clinical Genetics |
| title | Gene polymorphisms in association with self-reported stroke in US adults |
| title_full | Gene polymorphisms in association with self-reported stroke in US adults |
| title_fullStr | Gene polymorphisms in association with self-reported stroke in US adults |
| title_full_unstemmed | Gene polymorphisms in association with self-reported stroke in US adults |
| title_short | Gene polymorphisms in association with self-reported stroke in US adults |
| title_sort | gene polymorphisms in association with self reported stroke in us adults |
| url | http://www.dovepress.com/gene-polymorphisms-in-association-with-self-reported-stroke-in-us-adul-a4072 |
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