Effect of dietary wild pistachio oil on serum thyroid hormones, lipids and leptin concentration in experimental hyperthyroidism in male Rat
Background and Objective: Unsaturated fatty acids such as turpentine oil can decrease serum leptin level. In regard to this effect and the key role of thyroid hormones and leptin in metabolism. This study was designed to investigate the impact of dietary wild pistachio oil on serum leptin concentrat...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | fas |
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Golestan University of Medical Sciences
2010-01-01
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| Series: | مجله دانشگاه علوم پزشکی گرگان |
| Subjects: | |
| Online Access: | http://goums.ac.ir/journal/browse.php?a_code=A-10-1-423&slc_lang=en&sid=1 |
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| author | Mehdi Saeb (PhD) Saeed Nazifi (PhD) Mahsa Sabet (BSc) Habibollah Nazem (PhD) Hamid Reza Gheisari (PhD) Saeedeh Saeb (BSc) Jafar Jalaee (BSc) |
| author_facet | Mehdi Saeb (PhD) Saeed Nazifi (PhD) Mahsa Sabet (BSc) Habibollah Nazem (PhD) Hamid Reza Gheisari (PhD) Saeedeh Saeb (BSc) Jafar Jalaee (BSc) |
| author_sort | Mehdi Saeb (PhD) |
| collection | DOAJ |
| description | Background and Objective: Unsaturated fatty acids such as turpentine oil can decrease serum leptin level. In regard to this effect and the key role of thyroid hormones and leptin in metabolism. This study was designed to investigate the impact of dietary wild pistachio oil on serum leptin concentration and its relationship with thyroid hormones in experimental hyperthyroidism in male rat. Materials and Methods: In this experimental study thirty white Sprague Dawely adult male rats were divided randomly into the five groups with six rats in each. The first group as a natural control I received only ordinary diet and water during the study period. The second group as a control II received ordinary diet in addition to administration of 12mg Sigma levothyroxine in one liter of water daily for one month. Third, fourth and fifth groups with administration of considered dosage of levothyroxine were received respectively 5%, 10% and 20% concentrations of wild pistachio oil for one month. Blood samples were obtained at 10-day intervals. T4, T3, fT4, fT3 and leptin were measured by RIA and ELISA methods. Serum lipid profiles were measured by enzymatic method. Results: Thyroidal hormones, lipids and leptin level did not show any statistically significant differences between experimental days in the rats of control group I.The serum concentrations of T4, T3, fT4, fT3 in third, T4 in fourth and fifth groups showed significant differences(P<0.05). The serum leptin concentration decreased significantly during the experiment in the third, fourth and fifth groups (P<0.05), but serum lipids did not show any significant differences between various days of experiment. Conclusion: This study showed that the level of T4, T3, fT4, fT3 and HDLc / LDLc ratio at 30th day of study in case groups compaing to controls were decreased and increased, respectively. |
| first_indexed | 2024-12-10T17:36:22Z |
| format | Article |
| id | doaj.art-3e8df1e5b0b844fd8070a8327c3ff6bd |
| institution | Directory Open Access Journal |
| issn | 1562-4765 2008-4080 |
| language | fas |
| last_indexed | 2024-12-10T17:36:22Z |
| publishDate | 2010-01-01 |
| publisher | Golestan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشگاه علوم پزشکی گرگان |
| spelling | doaj.art-3e8df1e5b0b844fd8070a8327c3ff6bd2022-12-22T01:39:31ZfasGolestan University of Medical Sciencesمجله دانشگاه علوم پزشکی گرگان1562-47652008-40802010-01-01114815Effect of dietary wild pistachio oil on serum thyroid hormones, lipids and leptin concentration in experimental hyperthyroidism in male RatMehdi Saeb (PhD)0Saeed Nazifi (PhD)1Mahsa Sabet (BSc)2Habibollah Nazem (PhD)3Hamid Reza Gheisari (PhD)4Saeedeh Saeb (BSc)5Jafar Jalaee (BSc)6 Background and Objective: Unsaturated fatty acids such as turpentine oil can decrease serum leptin level. In regard to this effect and the key role of thyroid hormones and leptin in metabolism. This study was designed to investigate the impact of dietary wild pistachio oil on serum leptin concentration and its relationship with thyroid hormones in experimental hyperthyroidism in male rat. Materials and Methods: In this experimental study thirty white Sprague Dawely adult male rats were divided randomly into the five groups with six rats in each. The first group as a natural control I received only ordinary diet and water during the study period. The second group as a control II received ordinary diet in addition to administration of 12mg Sigma levothyroxine in one liter of water daily for one month. Third, fourth and fifth groups with administration of considered dosage of levothyroxine were received respectively 5%, 10% and 20% concentrations of wild pistachio oil for one month. Blood samples were obtained at 10-day intervals. T4, T3, fT4, fT3 and leptin were measured by RIA and ELISA methods. Serum lipid profiles were measured by enzymatic method. Results: Thyroidal hormones, lipids and leptin level did not show any statistically significant differences between experimental days in the rats of control group I.The serum concentrations of T4, T3, fT4, fT3 in third, T4 in fourth and fifth groups showed significant differences(P<0.05). The serum leptin concentration decreased significantly during the experiment in the third, fourth and fifth groups (P<0.05), but serum lipids did not show any significant differences between various days of experiment. Conclusion: This study showed that the level of T4, T3, fT4, fT3 and HDLc / LDLc ratio at 30th day of study in case groups compaing to controls were decreased and increased, respectively.http://goums.ac.ir/journal/browse.php?a_code=A-10-1-423&slc_lang=en&sid=1Wild pistachio oilLeptinHyperthyroidismThyroid hormonesSerum lipidsRat |
| spellingShingle | Mehdi Saeb (PhD) Saeed Nazifi (PhD) Mahsa Sabet (BSc) Habibollah Nazem (PhD) Hamid Reza Gheisari (PhD) Saeedeh Saeb (BSc) Jafar Jalaee (BSc) Effect of dietary wild pistachio oil on serum thyroid hormones, lipids and leptin concentration in experimental hyperthyroidism in male Rat مجله دانشگاه علوم پزشکی گرگان Wild pistachio oil Leptin Hyperthyroidism Thyroid hormones Serum lipids Rat |
| title | Effect of dietary wild pistachio oil on serum thyroid hormones, lipids and leptin concentration in experimental hyperthyroidism in male Rat |
| title_full | Effect of dietary wild pistachio oil on serum thyroid hormones, lipids and leptin concentration in experimental hyperthyroidism in male Rat |
| title_fullStr | Effect of dietary wild pistachio oil on serum thyroid hormones, lipids and leptin concentration in experimental hyperthyroidism in male Rat |
| title_full_unstemmed | Effect of dietary wild pistachio oil on serum thyroid hormones, lipids and leptin concentration in experimental hyperthyroidism in male Rat |
| title_short | Effect of dietary wild pistachio oil on serum thyroid hormones, lipids and leptin concentration in experimental hyperthyroidism in male Rat |
| title_sort | effect of dietary wild pistachio oil on serum thyroid hormones lipids and leptin concentration in experimental hyperthyroidism in male rat |
| topic | Wild pistachio oil Leptin Hyperthyroidism Thyroid hormones Serum lipids Rat |
| url | http://goums.ac.ir/journal/browse.php?a_code=A-10-1-423&slc_lang=en&sid=1 |
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