Reversal of stage 5 chronic kidney disease by aortic valve replacement in kidney transplant recipient: a case report
Abstract Background Cardiorenal syndrome (CRS) is a group of pathophysiological disorders affecting heart and kidneys. Case presentation We present 44-year-old kidney transplant recipient with acute-on-chronic graft failure in the course of CRS due to acutely decompensated heart failure associated w...
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| Format: | Article |
| Language: | English |
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BMC
2020-01-01
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| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-020-01328-0 |
| _version_ | 1811270792761049088 |
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| author | E. Hryniewiecka T. Hryniewiecki J. Różański T. Pilecki R. Zagożdżon T. Orłowski M. Gołębiowski L. Pączek K. Mucha B. Foroncewicz |
| author_facet | E. Hryniewiecka T. Hryniewiecki J. Różański T. Pilecki R. Zagożdżon T. Orłowski M. Gołębiowski L. Pączek K. Mucha B. Foroncewicz |
| author_sort | E. Hryniewiecka |
| collection | DOAJ |
| description | Abstract Background Cardiorenal syndrome (CRS) is a group of pathophysiological disorders affecting heart and kidneys. Case presentation We present 44-year-old kidney transplant recipient with acute-on-chronic graft failure in the course of CRS due to acutely decompensated heart failure associated with severe aortic regurgitation successfully treated with aortic valve replacement. Because of graft failure progression and difficult to eradicate infections he was treated with dialysis and radical minimization of immunosuppression. After 74 days of renal replacement therapy the patient regained graft function after successful aortic valve replacement. The dialysis could be stopped and immunosuppressive therapy was reintroduced. Heart and renal function are stable and patient is doing well without dialysis for 3 years. Conclusions The return of kidney graft function can occur even after a long period of dialysis therapy due to improved cardiovascular function. Therefore, distinguishing an acute-on-chronic CRS subtype is mandatory to enable specific patient approach. |
| first_indexed | 2024-04-12T22:08:26Z |
| format | Article |
| id | doaj.art-3e8e329144404f1a86bfc82cda658cd0 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-04-12T22:08:26Z |
| publishDate | 2020-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-3e8e329144404f1a86bfc82cda658cd02022-12-22T03:14:50ZengBMCBMC Cardiovascular Disorders1471-22612020-01-012011510.1186/s12872-020-01328-0Reversal of stage 5 chronic kidney disease by aortic valve replacement in kidney transplant recipient: a case reportE. Hryniewiecka0T. Hryniewiecki1J. Różański2T. Pilecki3R. Zagożdżon4T. Orłowski5M. Gołębiowski6L. Pączek7K. Mucha8B. Foroncewicz9Department of Immunology, Transplantology and Internal Diseases, Medical University of WarsawDepartment of Acquired Cardiac Defects, Institute of CardiologyDepartment of Cardiosurgery and Transplantology, Institute of CardiologyDepartment of Immunology, Transplantology and Internal Diseases, Medical University of WarsawDepartment of Clinical Immunology, Medical University of WarsawDepartment of Thoracic Surgery, National Tuberculosis and Lung Disease Research InstituteDepartment of Clinical Radiology, Medical University of WarsawDepartment of Immunology, Transplantology and Internal Diseases, Medical University of WarsawDepartment of Immunology, Transplantology and Internal Diseases, Medical University of WarsawDepartment of Immunology, Transplantology and Internal Diseases, Medical University of WarsawAbstract Background Cardiorenal syndrome (CRS) is a group of pathophysiological disorders affecting heart and kidneys. Case presentation We present 44-year-old kidney transplant recipient with acute-on-chronic graft failure in the course of CRS due to acutely decompensated heart failure associated with severe aortic regurgitation successfully treated with aortic valve replacement. Because of graft failure progression and difficult to eradicate infections he was treated with dialysis and radical minimization of immunosuppression. After 74 days of renal replacement therapy the patient regained graft function after successful aortic valve replacement. The dialysis could be stopped and immunosuppressive therapy was reintroduced. Heart and renal function are stable and patient is doing well without dialysis for 3 years. Conclusions The return of kidney graft function can occur even after a long period of dialysis therapy due to improved cardiovascular function. Therefore, distinguishing an acute-on-chronic CRS subtype is mandatory to enable specific patient approach.https://doi.org/10.1186/s12872-020-01328-0Kidney transplantationEnd stage renal diseaseAcute-on-chronicHaemodialysisCardiorenal syndromeAortic insufficiency |
| spellingShingle | E. Hryniewiecka T. Hryniewiecki J. Różański T. Pilecki R. Zagożdżon T. Orłowski M. Gołębiowski L. Pączek K. Mucha B. Foroncewicz Reversal of stage 5 chronic kidney disease by aortic valve replacement in kidney transplant recipient: a case report BMC Cardiovascular Disorders Kidney transplantation End stage renal disease Acute-on-chronic Haemodialysis Cardiorenal syndrome Aortic insufficiency |
| title | Reversal of stage 5 chronic kidney disease by aortic valve replacement in kidney transplant recipient: a case report |
| title_full | Reversal of stage 5 chronic kidney disease by aortic valve replacement in kidney transplant recipient: a case report |
| title_fullStr | Reversal of stage 5 chronic kidney disease by aortic valve replacement in kidney transplant recipient: a case report |
| title_full_unstemmed | Reversal of stage 5 chronic kidney disease by aortic valve replacement in kidney transplant recipient: a case report |
| title_short | Reversal of stage 5 chronic kidney disease by aortic valve replacement in kidney transplant recipient: a case report |
| title_sort | reversal of stage 5 chronic kidney disease by aortic valve replacement in kidney transplant recipient a case report |
| topic | Kidney transplantation End stage renal disease Acute-on-chronic Haemodialysis Cardiorenal syndrome Aortic insufficiency |
| url | https://doi.org/10.1186/s12872-020-01328-0 |
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