Effects of Lipid Lowering Therapy Optimization by PCSK9 Inhibitors on Circulating CD34+ Cells and Pulse Wave Velocity in Familial Hypercholesterolemia Subjects without Atherosclerotic Cardiovascular Disease: Real-World Data from Two Lipid Units

Effects of Lipid Lowering Therapy Optimization by PCSK9 Inhibitors on Circulating CD34+ Cells and Pulse Wave Velocity in Familial Hypercholesterolemia Subjects without Atherosclerotic Cardiovascular Disease: Real-World Data from Two Lipid Units

Background: Circulating CD34+ progenitor cells (CD34+CPCs) are characterized by pronounced tissue regeneration activity. Dyslipidemic subjects seemed to have reduced CD34+CPCs, and statin therapy appeared to restore their levels. We aimed to evaluate the effects of PCSK9 inhibitors (PCSK9-i) on CD34...

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Bibliographic Details
Main Authors: Roberto Scicali, Giuseppe Mandraffino, Michele Scuruchi, Alberto Lo Gullo, Antonino Di Pino, Viviana Ferrara, Carmela Morace, Caterina Oriana Aragona, Giovanni Squadrito, Francesco Purrello, Salvatore Piro
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Biomedicines
Subjects:
circulating CD34+ cells
familial hypercholesterolemia
PCSK9 inhibitors
pulse wave velocity
cardiovascular risk
Online Access:https://www.mdpi.com/2227-9059/10/7/1715

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