Blocking EREG/GPX4 Sensitizes Head and Neck Cancer to Cetuximab through Ferroptosis Induction

Blocking EREG/GPX4 Sensitizes Head and Neck Cancer to Cetuximab through Ferroptosis Induction

(1) Background: Epiregulin (EREG) is a ligand of EGFR and ErB4 involved in the development and the progression of various cancers including head and neck squamous cell carcinoma (HNSCC). Its overexpression in HNSCC is correlated with short overall survival and progression-free survival but predictiv...

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Bibliographic Details
Main Authors: Aude Jehl, Ombline Conrad, Mickaël Burgy, Sophie Foppolo, Romain Vauchelles, Carole Ronzani, Nelly Etienne-Selloum, Marie-Pierre Chenard, Aurélien Danic, Thomas Dourlhes, Claire Thibault, Philippe Schultz, Monique Dontenwill, Sophie Martin
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Cells
Subjects:
head and neck cancers
EREG
ferroptosis
tumoroid
biomarkers
metabolism
Online Access:https://www.mdpi.com/2073-4409/12/5/733

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