Blood loss and transcapillary refill in uncontrolled treated hemorrhage in dogs
OBJETIVE: This study evaluated retroperitoneal hematomas produced by bilateral injury of iliac arteries (uncontrolled hemorrhage), blood volume loss, transcapillary refill, the effects of volume replacement on retroperitoneal bleeding and the hemodynamic changes with and without treatment. METHODS:...
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| Format: | Article |
| Language: | English |
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Elsevier España
2010-01-01
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| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322010000100011 |
| _version_ | 1818114223401598976 |
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| author | Elias Aissar Sallum Sueli Sinozaki Ana Maria Calil Raul Coimbra Maurício Rocha E Silva Luis Francisco Poli de Figueiredo Dario Birolini |
| author_facet | Elias Aissar Sallum Sueli Sinozaki Ana Maria Calil Raul Coimbra Maurício Rocha E Silva Luis Francisco Poli de Figueiredo Dario Birolini |
| author_sort | Elias Aissar Sallum |
| collection | DOAJ |
| description | OBJETIVE: This study evaluated retroperitoneal hematomas produced by bilateral injury of iliac arteries (uncontrolled hemorrhage), blood volume loss, transcapillary refill, the effects of volume replacement on retroperitoneal bleeding and the hemodynamic changes with and without treatment. METHODS: Initial blood volume was determined with Tc99m-labelled red cells, and bleeding was evaluated by means of a portable scintillation camera positioned over the abdomen. Previously splenectomized mongrel dogs (16.8 ± 2.2 kg) were submitted to hemorrhage for 30 minutes and randomized into three groups: I - no treatment (n=7); II - treatment with 32 mL/kg of Lactated Ringer's for three to five minutes (n=7); and III - treatment with 4 mL/kg of 7.5% NaCl plus 6.0% dextran 70 for three to five minutes (n=7). They were studied for an additional 45 minutes. RESULTS: Volume replacement produced transitory recovery in hemodynamic variables, including mean pulmonary artery pressure, pulmonary capillary wedge pressure and cardiac index, with significant increase in dogs treated with 32 mL/kg of Lactated Ringer's and 7.5% NaCl plus 6.0% dextran 70 (p<0.001, against no treatment), along with a decrease (p<0.001) in the systemic vascular resistance index. Groups II and III had significant initial decreases in hematocrit and hemoglobin. The treated dogs (groups II and III) presented rebleeding, which was greater during treatment with 32 mL/kg of Lactated Ringer's (group II). CONCLUSIONS: Despite the rebleeding observed in treated groups, the utilization of hypertonic saline solution with dextran proved to be effective in the initial reanimation, producing evident transcapillary refill, while the Lactated Ringer's solution produced capillary extravasation and was ineffective in the initial volume replacement in this model of uncontrolled hemorrhage. |
| first_indexed | 2024-12-11T03:47:19Z |
| format | Article |
| id | doaj.art-3e9139a536f24d4cacb3b0c21d574a94 |
| institution | Directory Open Access Journal |
| issn | 1807-5932 1980-5322 |
| language | English |
| last_indexed | 2024-12-11T03:47:19Z |
| publishDate | 2010-01-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-3e9139a536f24d4cacb3b0c21d574a942022-12-22T01:21:59ZengElsevier EspañaClinics1807-59321980-53222010-01-01651677810.1590/S1807-59322010000100011Blood loss and transcapillary refill in uncontrolled treated hemorrhage in dogsElias Aissar SallumSueli SinozakiAna Maria CalilRaul CoimbraMaurício Rocha E SilvaLuis Francisco Poli de FigueiredoDario BiroliniOBJETIVE: This study evaluated retroperitoneal hematomas produced by bilateral injury of iliac arteries (uncontrolled hemorrhage), blood volume loss, transcapillary refill, the effects of volume replacement on retroperitoneal bleeding and the hemodynamic changes with and without treatment. METHODS: Initial blood volume was determined with Tc99m-labelled red cells, and bleeding was evaluated by means of a portable scintillation camera positioned over the abdomen. Previously splenectomized mongrel dogs (16.8 ± 2.2 kg) were submitted to hemorrhage for 30 minutes and randomized into three groups: I - no treatment (n=7); II - treatment with 32 mL/kg of Lactated Ringer's for three to five minutes (n=7); and III - treatment with 4 mL/kg of 7.5% NaCl plus 6.0% dextran 70 for three to five minutes (n=7). They were studied for an additional 45 minutes. RESULTS: Volume replacement produced transitory recovery in hemodynamic variables, including mean pulmonary artery pressure, pulmonary capillary wedge pressure and cardiac index, with significant increase in dogs treated with 32 mL/kg of Lactated Ringer's and 7.5% NaCl plus 6.0% dextran 70 (p<0.001, against no treatment), along with a decrease (p<0.001) in the systemic vascular resistance index. Groups II and III had significant initial decreases in hematocrit and hemoglobin. The treated dogs (groups II and III) presented rebleeding, which was greater during treatment with 32 mL/kg of Lactated Ringer's (group II). CONCLUSIONS: Despite the rebleeding observed in treated groups, the utilization of hypertonic saline solution with dextran proved to be effective in the initial reanimation, producing evident transcapillary refill, while the Lactated Ringer's solution produced capillary extravasation and was ineffective in the initial volume replacement in this model of uncontrolled hemorrhage.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322010000100011Retroperitoneal hematomaUncontrolled hemorrhageShockHypertonic saline solutionSmall volume resuscitation |
| spellingShingle | Elias Aissar Sallum Sueli Sinozaki Ana Maria Calil Raul Coimbra Maurício Rocha E Silva Luis Francisco Poli de Figueiredo Dario Birolini Blood loss and transcapillary refill in uncontrolled treated hemorrhage in dogs Clinics Retroperitoneal hematoma Uncontrolled hemorrhage Shock Hypertonic saline solution Small volume resuscitation |
| title | Blood loss and transcapillary refill in uncontrolled treated hemorrhage in dogs |
| title_full | Blood loss and transcapillary refill in uncontrolled treated hemorrhage in dogs |
| title_fullStr | Blood loss and transcapillary refill in uncontrolled treated hemorrhage in dogs |
| title_full_unstemmed | Blood loss and transcapillary refill in uncontrolled treated hemorrhage in dogs |
| title_short | Blood loss and transcapillary refill in uncontrolled treated hemorrhage in dogs |
| title_sort | blood loss and transcapillary refill in uncontrolled treated hemorrhage in dogs |
| topic | Retroperitoneal hematoma Uncontrolled hemorrhage Shock Hypertonic saline solution Small volume resuscitation |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322010000100011 |
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