Structural, functional, and metabolic signatures of postpartum depression: A systematic review
ObjectivePostpartum depression (PPD) is a serious condition with debilitating consequences for the mother, offspring, and the whole family. The scope of negative outcomes of PPD highlights the need to specify effective diagnostics and treatment which might differ from major depressive disorder (MDD)...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1044995/full |
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| author | Anna Horáková Anna Horáková Hana Němcová Hana Němcová Pavel Mohr Pavel Mohr Antonin Sebela Antonin Sebela |
| author_facet | Anna Horáková Anna Horáková Hana Němcová Hana Němcová Pavel Mohr Pavel Mohr Antonin Sebela Antonin Sebela |
| author_sort | Anna Horáková |
| collection | DOAJ |
| description | ObjectivePostpartum depression (PPD) is a serious condition with debilitating consequences for the mother, offspring, and the whole family. The scope of negative outcomes of PPD highlights the need to specify effective diagnostics and treatment which might differ from major depressive disorder (MDD). In order to improve our clinical care, we need to better understand the underlying neuropathological mechanisms of PPD. Therefore, we conducted a systematic review of published neuroimaging studies assessing functional, structural, and metabolic correlates of PPD.MethodsRelevant papers were identified using a search code for English-written studies in the PubMed, Scopus, and Web of Science databases published by March 2022. Included were studies with structural magnetic resonance imaging, functional magnetic resonance imaging, both resting-state and task-related, magnetic resonance spectroscopy, or positron emission tomography. The findings were analyzed to assess signatures in PPD-diagnosed women compared to healthy controls. The review protocol was registered in PROSPERO (CRD42022313794).ResultsThe total of 3,368 references were initially identified. After the removal of duplicates and non-applicable papers, the search yielded 74 full-text studies assessed for eligibility. Of them, 26 met the inclusion criteria and their findings were analyzed and synthesized. The results showed consistent functional, structural, and metabolic changes in the default mode network and the salient network in women with PPD. During emotion-related tasks, PPD was associated with changes in the corticolimbic system activity, especially the amygdala.DiscussionThis review offers a comprehensive summary of neuroimaging signatures in PPD-diagnosed women. It indicates the brain regions and networks which show functional, structural, and metabolic changes. Our findings offer better understanding of the nature of PPD, which clearly copies some features of MDD, while differs in others. |
| first_indexed | 2024-04-11T08:09:02Z |
| format | Article |
| id | doaj.art-3e93a9b1a50949869ba1a7df9f1486f7 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-11T08:09:02Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-3e93a9b1a50949869ba1a7df9f1486f72022-12-22T04:35:24ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402022-11-011310.3389/fpsyt.2022.10449951044995Structural, functional, and metabolic signatures of postpartum depression: A systematic reviewAnna Horáková0Anna Horáková1Hana Němcová2Hana Němcová3Pavel Mohr4Pavel Mohr5Antonin Sebela6Antonin Sebela7Center of Perinatal Mental Health, National Institute of Mental Health, Klecany, CzechiaDepartment of Psychology, Faculty of Arts, Charles University, Prague, CzechiaCenter of Perinatal Mental Health, National Institute of Mental Health, Klecany, CzechiaDepartment of Psychology, Faculty of Arts, Charles University, Prague, CzechiaDepartment of Psychiatry and Medical Psychology, Third Faculty of Medicine, Charles University, Prague, CzechiaClinical Center, National Institute of Mental Health, Klecany, CzechiaCenter of Perinatal Mental Health, National Institute of Mental Health, Klecany, CzechiaDepartment of Psychiatry and Medical Psychology, Third Faculty of Medicine, Charles University, Prague, CzechiaObjectivePostpartum depression (PPD) is a serious condition with debilitating consequences for the mother, offspring, and the whole family. The scope of negative outcomes of PPD highlights the need to specify effective diagnostics and treatment which might differ from major depressive disorder (MDD). In order to improve our clinical care, we need to better understand the underlying neuropathological mechanisms of PPD. Therefore, we conducted a systematic review of published neuroimaging studies assessing functional, structural, and metabolic correlates of PPD.MethodsRelevant papers were identified using a search code for English-written studies in the PubMed, Scopus, and Web of Science databases published by March 2022. Included were studies with structural magnetic resonance imaging, functional magnetic resonance imaging, both resting-state and task-related, magnetic resonance spectroscopy, or positron emission tomography. The findings were analyzed to assess signatures in PPD-diagnosed women compared to healthy controls. The review protocol was registered in PROSPERO (CRD42022313794).ResultsThe total of 3,368 references were initially identified. After the removal of duplicates and non-applicable papers, the search yielded 74 full-text studies assessed for eligibility. Of them, 26 met the inclusion criteria and their findings were analyzed and synthesized. The results showed consistent functional, structural, and metabolic changes in the default mode network and the salient network in women with PPD. During emotion-related tasks, PPD was associated with changes in the corticolimbic system activity, especially the amygdala.DiscussionThis review offers a comprehensive summary of neuroimaging signatures in PPD-diagnosed women. It indicates the brain regions and networks which show functional, structural, and metabolic changes. Our findings offer better understanding of the nature of PPD, which clearly copies some features of MDD, while differs in others.https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1044995/fullpostpartum depressionneuroimagingfMRImagnetic resonance spectroscopyperinatal depressionstructural MRI |
| spellingShingle | Anna Horáková Anna Horáková Hana Němcová Hana Němcová Pavel Mohr Pavel Mohr Antonin Sebela Antonin Sebela Structural, functional, and metabolic signatures of postpartum depression: A systematic review Frontiers in Psychiatry postpartum depression neuroimaging fMRI magnetic resonance spectroscopy perinatal depression structural MRI |
| title | Structural, functional, and metabolic signatures of postpartum depression: A systematic review |
| title_full | Structural, functional, and metabolic signatures of postpartum depression: A systematic review |
| title_fullStr | Structural, functional, and metabolic signatures of postpartum depression: A systematic review |
| title_full_unstemmed | Structural, functional, and metabolic signatures of postpartum depression: A systematic review |
| title_short | Structural, functional, and metabolic signatures of postpartum depression: A systematic review |
| title_sort | structural functional and metabolic signatures of postpartum depression a systematic review |
| topic | postpartum depression neuroimaging fMRI magnetic resonance spectroscopy perinatal depression structural MRI |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1044995/full |
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