BDNF Spinal Overexpression after Spinal Cord Injury Partially Protects Soleus Neuromuscular Junction from Disintegration, Increasing VAChT and AChE Transcripts in Soleus but Not Tibialis Anterior Motoneurons

BDNF Spinal Overexpression after Spinal Cord Injury Partially Protects Soleus Neuromuscular Junction from Disintegration, Increasing VAChT and AChE Transcripts in Soleus but Not Tibialis Anterior Motoneurons

After spinal cord transection (SCT) the interaction between motoneurons (MNs) and muscle is impaired, due to reorganization of the spinal network after a loss of supraspinal inputs. Rats subjected to SCT, treated with intraspinal injection of a AAV-BDNF (brain-derived neurotrophic factor) construct,...

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Bibliographic Details
Main Authors: Anna Głowacka, Benjun Ji, Andrzej Antoni Szczepankiewicz, Małgorzata Skup, Olga Gajewska-Woźniak
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Biomedicines
Subjects:
acetylcholine
nicotinic ACh receptor
brain-derived neurotrophic factor
spinal cord transection
neuromuscular junction
extensor and flexor muscle of the ankle joint
Online Access:https://www.mdpi.com/2227-9059/10/11/2851

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