Flumazenil Pretreatment Reduces Mefenamic Acid-Induced Central Nervous System Toxicity in Mice

Flumazenil Pretreatment Reduces Mefenamic Acid-Induced Central Nervous System Toxicity in Mice

Background: Mefenamic acid (MFA), a common analgesic, causes central nervous system (CNS) toxicity at high doses with a proposed activity on the Gamma-aminobutyric acid (GABA) system. However, it remains unknown whether flumazenil (FMZ), a GABA type A receptor (GABAAR) antagonist, can reverse MFA to...

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Bibliographic Details
Main Authors: Qais Jarrar, Rami Ayoub, Yazun Jarrar, Hadeel Aburass, Khang Wen Goh, Chrismawan Ardianto, Long Chiau Ming, Said Moshawih, Hussain Alfaqih
Format: Article
Language:English
Published: IMR Press 2023-07-01
Series:Journal of Integrative Neuroscience
Subjects:
neurological disease
psychiatric disease
anxiety
central nervous system
convulsions
gamma-aminobutyric acid type a receptors
gaba
Online Access:https://www.imrpress.com/journal/JIN/22/4/10.31083/j.jin2204104

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https://www.imrpress.com/journal/JIN/22/4/10.31083/j.jin2204104

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