Analysis of Clinical and Genetic Factors of Obesity and Psoriasis Concomitance—The Influence of Body Mass Composition, Prevalence of Mood Disorders, Environmental Factors and <i>FTO</i> Gene Polymorphisms (rs9939609, rs1558902)
This study aimed to comprehensively analyze the problem of overweight and obesity among psoriatic patients by investigating the influence of body mass composition, anhedonia and depression, environmental factors and <i>FTO</i> gene polymorphisms. Methods: The study enrolled 30 overweight...
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MDPI AG
2024-02-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/12/3/517 |
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| author | Anna Czarnecka Dorota Purzycka-Bohdan Monika Zabłotna Roman J. Nowicki Krzysztof Rębała Michał Bohdan Marcin Gruchała Alina Wilkowska Aneta Szczerkowska-Dobosz |
| author_facet | Anna Czarnecka Dorota Purzycka-Bohdan Monika Zabłotna Roman J. Nowicki Krzysztof Rębała Michał Bohdan Marcin Gruchała Alina Wilkowska Aneta Szczerkowska-Dobosz |
| author_sort | Anna Czarnecka |
| collection | DOAJ |
| description | This study aimed to comprehensively analyze the problem of overweight and obesity among psoriatic patients by investigating the influence of body mass composition, anhedonia and depression, environmental factors and <i>FTO</i> gene polymorphisms. Methods: The study enrolled 30 overweight or obese adult patients with chronic plaque psoriasis and 30 overweight or obese volunteers (northern Poland region, Caucasian population). Mood disorders, body mass composition by using bioelectrical impedance analysis (BIA) and <i>FTO</i> gene polymorphisms (rs9939609, rs1558902) by tetra-primer amplification refractory mutation system PCR (T-ARMS-PCR) were assessed. Results: Results revealed significantly higher visceral adipose tissue levels in psoriatic patients (5.23 ± 2.29 [L] vs. 3.41 ± 1.86 [L]), <i>p</i> = 0.001), especially among men, along with elevated rates of moderate and severe depression (26.67% vs. 6.67% and 13.33% vs. 3.33%, <i>p</i> = 0.048 respectively). Additionally, <i>FTO</i> gene polymorphisms correlated with waist–hip ratio differences in both groups. Conclusions: The study highlights the importance of evaluating body composition beyond body mass index, recognizing its influence on psoriasis and associated conditions like depression. The <i>FTO</i> gene may serve as a potential genetic link between psoriasis and obesity, warranting further research for validation. Adiposity emerges as a key and modifiable risk factor, underscoring the clinical implications of body composition complexities in psoriasis management. |
| first_indexed | 2024-04-24T18:32:08Z |
| format | Article |
| id | doaj.art-3e95597b9f82438fa11b430500d87dc9 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-04-24T18:32:08Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-3e95597b9f82438fa11b430500d87dc92024-03-27T13:22:38ZengMDPI AGBiomedicines2227-90592024-02-0112351710.3390/biomedicines12030517Analysis of Clinical and Genetic Factors of Obesity and Psoriasis Concomitance—The Influence of Body Mass Composition, Prevalence of Mood Disorders, Environmental Factors and <i>FTO</i> Gene Polymorphisms (rs9939609, rs1558902)Anna Czarnecka0Dorota Purzycka-Bohdan1Monika Zabłotna2Roman J. Nowicki3Krzysztof Rębała4Michał Bohdan5Marcin Gruchała6Alina Wilkowska7Aneta Szczerkowska-Dobosz8Department of Dermatology, Venereology and Allergology, Medical University of Gdańsk, 80-210 Gdańsk, PolandDepartment of Dermatology, Venereology and Allergology, Medical University of Gdańsk, 80-210 Gdańsk, PolandDepartment of Dermatology, Venereology and Allergology, Medical University of Gdańsk, 80-210 Gdańsk, PolandDepartment of Dermatology, Venereology and Allergology, Medical University of Gdańsk, 80-210 Gdańsk, PolandDepartment of Forensic Medicine, Medical University of Gdańsk, 80-210 Gdańsk, Poland1st Department of Cardiology, Medical University of Gdańsk, 80-210 Gdańsk, Poland1st Department of Cardiology, Medical University of Gdańsk, 80-210 Gdańsk, PolandDepartment of Psychiatry, Medical University of Gdańsk, 80-210 Gdańsk, PolandDepartment of Dermatology, Venereology and Allergology, Medical University of Gdańsk, 80-210 Gdańsk, PolandThis study aimed to comprehensively analyze the problem of overweight and obesity among psoriatic patients by investigating the influence of body mass composition, anhedonia and depression, environmental factors and <i>FTO</i> gene polymorphisms. Methods: The study enrolled 30 overweight or obese adult patients with chronic plaque psoriasis and 30 overweight or obese volunteers (northern Poland region, Caucasian population). Mood disorders, body mass composition by using bioelectrical impedance analysis (BIA) and <i>FTO</i> gene polymorphisms (rs9939609, rs1558902) by tetra-primer amplification refractory mutation system PCR (T-ARMS-PCR) were assessed. Results: Results revealed significantly higher visceral adipose tissue levels in psoriatic patients (5.23 ± 2.29 [L] vs. 3.41 ± 1.86 [L]), <i>p</i> = 0.001), especially among men, along with elevated rates of moderate and severe depression (26.67% vs. 6.67% and 13.33% vs. 3.33%, <i>p</i> = 0.048 respectively). Additionally, <i>FTO</i> gene polymorphisms correlated with waist–hip ratio differences in both groups. Conclusions: The study highlights the importance of evaluating body composition beyond body mass index, recognizing its influence on psoriasis and associated conditions like depression. The <i>FTO</i> gene may serve as a potential genetic link between psoriasis and obesity, warranting further research for validation. Adiposity emerges as a key and modifiable risk factor, underscoring the clinical implications of body composition complexities in psoriasis management.https://www.mdpi.com/2227-9059/12/3/517psoriasisoverweightobesitydepressionBIA<i>FTO</i> polymorphisms |
| spellingShingle | Anna Czarnecka Dorota Purzycka-Bohdan Monika Zabłotna Roman J. Nowicki Krzysztof Rębała Michał Bohdan Marcin Gruchała Alina Wilkowska Aneta Szczerkowska-Dobosz Analysis of Clinical and Genetic Factors of Obesity and Psoriasis Concomitance—The Influence of Body Mass Composition, Prevalence of Mood Disorders, Environmental Factors and <i>FTO</i> Gene Polymorphisms (rs9939609, rs1558902) Biomedicines psoriasis overweight obesity depression BIA <i>FTO</i> polymorphisms |
| title | Analysis of Clinical and Genetic Factors of Obesity and Psoriasis Concomitance—The Influence of Body Mass Composition, Prevalence of Mood Disorders, Environmental Factors and <i>FTO</i> Gene Polymorphisms (rs9939609, rs1558902) |
| title_full | Analysis of Clinical and Genetic Factors of Obesity and Psoriasis Concomitance—The Influence of Body Mass Composition, Prevalence of Mood Disorders, Environmental Factors and <i>FTO</i> Gene Polymorphisms (rs9939609, rs1558902) |
| title_fullStr | Analysis of Clinical and Genetic Factors of Obesity and Psoriasis Concomitance—The Influence of Body Mass Composition, Prevalence of Mood Disorders, Environmental Factors and <i>FTO</i> Gene Polymorphisms (rs9939609, rs1558902) |
| title_full_unstemmed | Analysis of Clinical and Genetic Factors of Obesity and Psoriasis Concomitance—The Influence of Body Mass Composition, Prevalence of Mood Disorders, Environmental Factors and <i>FTO</i> Gene Polymorphisms (rs9939609, rs1558902) |
| title_short | Analysis of Clinical and Genetic Factors of Obesity and Psoriasis Concomitance—The Influence of Body Mass Composition, Prevalence of Mood Disorders, Environmental Factors and <i>FTO</i> Gene Polymorphisms (rs9939609, rs1558902) |
| title_sort | analysis of clinical and genetic factors of obesity and psoriasis concomitance the influence of body mass composition prevalence of mood disorders environmental factors and i fto i gene polymorphisms rs9939609 rs1558902 |
| topic | psoriasis overweight obesity depression BIA <i>FTO</i> polymorphisms |
| url | https://www.mdpi.com/2227-9059/12/3/517 |
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