The Impact of Computed Tomography Measurements of Sarcopenia on Postoperative and Oncologic Outcomes in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is a treatment option for peritoneal metastases (PM) but is associated with significant postoperative morbidity. The aim of this study was to determine the prognostic value of computed tomographic (CT)-measured sarcopen...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/29/12/730 |
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| author | Maher Al Khaldi Massine Fellouah Pierre Drolet Julien Côté Bertrand Trilling Alexandre Brind’Amour Alexandre Dugas Jean-François Tremblay Suzanne Fortin Lara De Guerké Marie-Hélène Auclair Pierre Dubé Mikaël Soucisse Lucas Sideris |
| author_facet | Maher Al Khaldi Massine Fellouah Pierre Drolet Julien Côté Bertrand Trilling Alexandre Brind’Amour Alexandre Dugas Jean-François Tremblay Suzanne Fortin Lara De Guerké Marie-Hélène Auclair Pierre Dubé Mikaël Soucisse Lucas Sideris |
| author_sort | Maher Al Khaldi |
| collection | DOAJ |
| description | Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is a treatment option for peritoneal metastases (PM) but is associated with significant postoperative morbidity. The aim of this study was to determine the prognostic value of computed tomographic (CT)-measured sarcopenia on postoperative outcomes and survival in patients undergoing CRS-HIPEC for PM from various origins. A retrospective cohort study was conducted between 2012 and 2020. Three-hundred and twelve patients (mean age 57.6 ± 10.3, 34.3% male) were included, of which 88 (28.2%) were sarcopenic. PM from a colorectal origin was the most common in both groups. The proportion of major postoperative complications (Clavien-Dindo ≥ III) was not higher in the sarcopenic group (15.9% in sarcopenic patients vs. 23.2% in nonsarcopenic patients, <i>p</i> = 0.17). The mean Comprehensive Complication Index scores, HIPEC-related toxicities, length of hospital stay, and duration of parenteral nutrition were comparable regardless of sarcopenia status. In the multivariate logistic regression analysis of severe complications, only peritoneal carcinomatosis index reached statistical significance (OR, 1.05; 95% CI, 1.01 to 1.08, <i>p</i> = 0.007). Sarcopenia did not impact origin-specific overall survival on Cox regression analysis. Sarcopenia was not associated with worse rates of postoperative severe complications or worse survival rates. Future prospective studies are required before considering sarcopenia as part of preoperative risk assessment. |
| first_indexed | 2024-03-09T17:09:09Z |
| format | Article |
| id | doaj.art-3e958d4450ea4847a53e4da8a9459006 |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-09T17:09:09Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-3e958d4450ea4847a53e4da8a94590062023-11-24T14:12:33ZengMDPI AGCurrent Oncology1198-00521718-77292022-11-0129129314932410.3390/curroncol29120730The Impact of Computed Tomography Measurements of Sarcopenia on Postoperative and Oncologic Outcomes in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal ChemotherapyMaher Al Khaldi0Massine Fellouah1Pierre Drolet2Julien Côté3Bertrand Trilling4Alexandre Brind’Amour5Alexandre Dugas6Jean-François Tremblay7Suzanne Fortin8Lara De Guerké9Marie-Hélène Auclair10Pierre Dubé11Mikaël Soucisse12Lucas Sideris13Division of Surgical Oncology, Department of Surgery, Hôpital Maisonneuve-Rosemont, CIUSS de l’Est de l’ïle de Montréal, Montréal, QC H1T 2M4, CanadaDivision of Surgical Oncology, Department of Surgery, Hôpital Maisonneuve-Rosemont, CIUSS de l’Est de l’ïle de Montréal, Montréal, QC H1T 2M4, CanadaDepartment of Anesthesiology, Hôpital Maisonneuve-Rosemont, CIUSSS de l’Est de l’Île de Montréal, Montréal, QC H1T 2M4, CanadaDivision of Surgical Oncology, Department of Surgery, Hôpital Maisonneuve-Rosemont, CIUSS de l’Est de l’ïle de Montréal, Montréal, QC H1T 2M4, CanadaDivision of Surgical Oncology, Department of Surgery, Hôpital Maisonneuve-Rosemont, CIUSS de l’Est de l’ïle de Montréal, Montréal, QC H1T 2M4, CanadaDivision of Surgical Oncology, Department of Surgery, Hôpital Maisonneuve-Rosemont, CIUSS de l’Est de l’ïle de Montréal, Montréal, QC H1T 2M4, CanadaDivision Abdominal Radiology, Department of Radiology, Maisonneuve-Rosemont, CIUSSS de l’Est de l’Île de Montréal, Montréal, QC H1T 2M4, CanadaDivision of Colorectal Surgery, Department of Surgery, Hôpital Maisonneuve-Rosemont, CIUSSS de l’Est de l’Île de Montréal, Montréal, QC H1T 2M4, CanadaDivision of Gynecologic Oncology, Department of Surgery, Hôpital Maisonneuve-Rosemont, CIUSSS de l’Est de l’Île de Montréal, Montréal, QC H1T 2M4, CanadaDivision of Gynecologic Oncology, Department of Surgery, Hôpital Maisonneuve-Rosemont, CIUSSS de l’Est de l’Île de Montréal, Montréal, QC H1T 2M4, CanadaDivision of Gynecologic Oncology, Department of Surgery, Hôpital Maisonneuve-Rosemont, CIUSSS de l’Est de l’Île de Montréal, Montréal, QC H1T 2M4, CanadaDivision of Surgical Oncology, Department of Surgery, Hôpital Maisonneuve-Rosemont, CIUSS de l’Est de l’ïle de Montréal, Montréal, QC H1T 2M4, CanadaDivision of Surgical Oncology, Department of Surgery, Hôpital Maisonneuve-Rosemont, CIUSS de l’Est de l’ïle de Montréal, Montréal, QC H1T 2M4, CanadaDivision of Surgical Oncology, Department of Surgery, Hôpital Maisonneuve-Rosemont, CIUSS de l’Est de l’ïle de Montréal, Montréal, QC H1T 2M4, CanadaCytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is a treatment option for peritoneal metastases (PM) but is associated with significant postoperative morbidity. The aim of this study was to determine the prognostic value of computed tomographic (CT)-measured sarcopenia on postoperative outcomes and survival in patients undergoing CRS-HIPEC for PM from various origins. A retrospective cohort study was conducted between 2012 and 2020. Three-hundred and twelve patients (mean age 57.6 ± 10.3, 34.3% male) were included, of which 88 (28.2%) were sarcopenic. PM from a colorectal origin was the most common in both groups. The proportion of major postoperative complications (Clavien-Dindo ≥ III) was not higher in the sarcopenic group (15.9% in sarcopenic patients vs. 23.2% in nonsarcopenic patients, <i>p</i> = 0.17). The mean Comprehensive Complication Index scores, HIPEC-related toxicities, length of hospital stay, and duration of parenteral nutrition were comparable regardless of sarcopenia status. In the multivariate logistic regression analysis of severe complications, only peritoneal carcinomatosis index reached statistical significance (OR, 1.05; 95% CI, 1.01 to 1.08, <i>p</i> = 0.007). Sarcopenia did not impact origin-specific overall survival on Cox regression analysis. Sarcopenia was not associated with worse rates of postoperative severe complications or worse survival rates. Future prospective studies are required before considering sarcopenia as part of preoperative risk assessment.https://www.mdpi.com/1718-7729/29/12/730sarcopeniaperitoneal metastasescytoreductive surgery and hyperthermic intraperitoneal chemotherapy |
| spellingShingle | Maher Al Khaldi Massine Fellouah Pierre Drolet Julien Côté Bertrand Trilling Alexandre Brind’Amour Alexandre Dugas Jean-François Tremblay Suzanne Fortin Lara De Guerké Marie-Hélène Auclair Pierre Dubé Mikaël Soucisse Lucas Sideris The Impact of Computed Tomography Measurements of Sarcopenia on Postoperative and Oncologic Outcomes in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Current Oncology sarcopenia peritoneal metastases cytoreductive surgery and hyperthermic intraperitoneal chemotherapy |
| title | The Impact of Computed Tomography Measurements of Sarcopenia on Postoperative and Oncologic Outcomes in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy |
| title_full | The Impact of Computed Tomography Measurements of Sarcopenia on Postoperative and Oncologic Outcomes in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy |
| title_fullStr | The Impact of Computed Tomography Measurements of Sarcopenia on Postoperative and Oncologic Outcomes in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy |
| title_full_unstemmed | The Impact of Computed Tomography Measurements of Sarcopenia on Postoperative and Oncologic Outcomes in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy |
| title_short | The Impact of Computed Tomography Measurements of Sarcopenia on Postoperative and Oncologic Outcomes in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy |
| title_sort | impact of computed tomography measurements of sarcopenia on postoperative and oncologic outcomes in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy |
| topic | sarcopenia peritoneal metastases cytoreductive surgery and hyperthermic intraperitoneal chemotherapy |
| url | https://www.mdpi.com/1718-7729/29/12/730 |
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