Cardiovascular Inflammaging: Mechanisms and Translational Aspects
Aging is one of the major non-reversible risk factors for several chronic diseases, including cancer, type 2 diabetes, dementia, and cardiovascular diseases (CVD), and it is a key cause of multimorbidity, disability, and frailty (decreased physical activity, fatigue, and weight loss). The underlying...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/11/6/1010 |
| _version_ | 1797472363345870848 |
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| author | Maria Luisa Barcena Muhammad Aslam Sofya Pozdniakova Kristina Norman Yury Ladilov |
| author_facet | Maria Luisa Barcena Muhammad Aslam Sofya Pozdniakova Kristina Norman Yury Ladilov |
| author_sort | Maria Luisa Barcena |
| collection | DOAJ |
| description | Aging is one of the major non-reversible risk factors for several chronic diseases, including cancer, type 2 diabetes, dementia, and cardiovascular diseases (CVD), and it is a key cause of multimorbidity, disability, and frailty (decreased physical activity, fatigue, and weight loss). The underlying cellular mechanisms are complex and consist of multifactorial processes, such as telomere shortening, chronic low-grade inflammation, oxidative stress, mitochondrial dysfunction, accumulation of senescent cells, and reduced autophagy. In this review, we focused on the molecular mechanisms and translational aspects of cardiovascular aging-related inflammation, i.e., inflammaging. |
| first_indexed | 2024-03-09T20:00:47Z |
| format | Article |
| id | doaj.art-3e97019b38a2451dab2c4f716bcf7721 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T20:00:47Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-3e97019b38a2451dab2c4f716bcf77212023-11-24T00:44:35ZengMDPI AGCells2073-44092022-03-01116101010.3390/cells11061010Cardiovascular Inflammaging: Mechanisms and Translational AspectsMaria Luisa Barcena0Muhammad Aslam1Sofya Pozdniakova2Kristina Norman3Yury Ladilov4Department of Geriatrics and Medical Gerontology, Charité—Universitätsmedizin Berlin, Hindenburgdamm 30, 12203 Berlin, GermanyExperimental Cardiology, Department of Internal Medicine I, Justus Liebig University, Aulweg 129, 35392 Giessen, GermanyDepartment of Geriatrics and Medical Gerontology, Charité—Universitätsmedizin Berlin, Hindenburgdamm 30, 12203 Berlin, GermanyDepartment of Geriatrics and Medical Gerontology, Charité—Universitätsmedizin Berlin, Hindenburgdamm 30, 12203 Berlin, GermanyDepartment of Geriatrics and Medical Gerontology, Charité—Universitätsmedizin Berlin, Hindenburgdamm 30, 12203 Berlin, GermanyAging is one of the major non-reversible risk factors for several chronic diseases, including cancer, type 2 diabetes, dementia, and cardiovascular diseases (CVD), and it is a key cause of multimorbidity, disability, and frailty (decreased physical activity, fatigue, and weight loss). The underlying cellular mechanisms are complex and consist of multifactorial processes, such as telomere shortening, chronic low-grade inflammation, oxidative stress, mitochondrial dysfunction, accumulation of senescent cells, and reduced autophagy. In this review, we focused on the molecular mechanisms and translational aspects of cardiovascular aging-related inflammation, i.e., inflammaging.https://www.mdpi.com/2073-4409/11/6/1010cardiac inflammagingvascular senescencemitochondrial homeostasismicrobiome |
| spellingShingle | Maria Luisa Barcena Muhammad Aslam Sofya Pozdniakova Kristina Norman Yury Ladilov Cardiovascular Inflammaging: Mechanisms and Translational Aspects Cells cardiac inflammaging vascular senescence mitochondrial homeostasis microbiome |
| title | Cardiovascular Inflammaging: Mechanisms and Translational Aspects |
| title_full | Cardiovascular Inflammaging: Mechanisms and Translational Aspects |
| title_fullStr | Cardiovascular Inflammaging: Mechanisms and Translational Aspects |
| title_full_unstemmed | Cardiovascular Inflammaging: Mechanisms and Translational Aspects |
| title_short | Cardiovascular Inflammaging: Mechanisms and Translational Aspects |
| title_sort | cardiovascular inflammaging mechanisms and translational aspects |
| topic | cardiac inflammaging vascular senescence mitochondrial homeostasis microbiome |
| url | https://www.mdpi.com/2073-4409/11/6/1010 |
| work_keys_str_mv | AT marialuisabarcena cardiovascularinflammagingmechanismsandtranslationalaspects AT muhammadaslam cardiovascularinflammagingmechanismsandtranslationalaspects AT sofyapozdniakova cardiovascularinflammagingmechanismsandtranslationalaspects AT kristinanorman cardiovascularinflammagingmechanismsandtranslationalaspects AT yuryladilov cardiovascularinflammagingmechanismsandtranslationalaspects |