Altered PPARγ Expression Promotes Myelin-Induced Foam Cell Formation in Macrophages in Multiple Sclerosis

Altered PPARγ Expression Promotes Myelin-Induced Foam Cell Formation in Macrophages in Multiple Sclerosis

Macrophages play a crucial role during the pathogenesis of multiple sclerosis (MS), a neuroinflammatory autoimmune disorder of the central nervous system. Important regulators of the metabolic and inflammatory phenotype of macrophages are liver X receptors (LXRs) and peroxisome proliferator-activate...

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Bibliographic Details
Main Authors: Elien Wouters, Elien Grajchen, Winde Jorissen, Tess Dierckx, Suzan Wetzels, Melanie Loix, Marie Paule Tulleners, Bart Staels, Piet Stinissen, Mansour Haidar, Jeroen F. J. Bogie, Jerome J. A. Hendriks
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
multiple sclerosis
myelin-loaded macrophages
inflammation
PPARγ
Online Access:https://www.mdpi.com/1422-0067/21/23/9329

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