Metformin mitigates SASP secretion and LPS-triggered hyper-inflammation in Doxorubicin-induced senescent endothelial cells

Metformin mitigates SASP secretion and LPS-triggered hyper-inflammation in Doxorubicin-induced senescent endothelial cells

Introduction: Doxorubicin (DOX), a chemotherapeutic drug, induces senescence and increases the secretion of senescence-associated secretory phenotype (SASP) in endothelial cells (ECs), which contributes to DOX-induced inflammaging. Metformin, an anti-diabetic drug, demonstrates senomorphic effects o...

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Bibliographic Details
Main Authors: Ibrahim Y. Abdelgawad, Kevin Agostinucci, Bushra Sadaf, Marianne K. O. Grant, Beshay N. Zordoky
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Aging
Subjects:
endothelial senescence
doxorubicin
metformin
SASP
LPS
senomorphics
Online Access:https://www.frontiersin.org/articles/10.3389/fragi.2023.1170434/full

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