Evaluation of Kidney Donor Risk Index/Kidney Donor Profile Index as Predictor Tools of Deceased-Donor Kidney Transplant Outcomes in a Greek Cohort
The Kidney Donor Risk Index (KDRI) and Kidney Donor Profile Index (KDPI) have been developed to assess deceased-donor graft quality, although validation of their utility outside the USA remains limited. This single-center retrospective cohort study evaluated the ability of KDRI and KDPI to predict t...
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| Format: | Article |
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MDPI AG
2023-03-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/6/2439 |
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| author | Maria Darema Diamanto Athanasopoulou Ioannis Bellos Ioanna Tsoumbou Angeliki G. Vittoraki John Bokos Smaragdi Marinaki Ioannis N. Boletis |
| author_facet | Maria Darema Diamanto Athanasopoulou Ioannis Bellos Ioanna Tsoumbou Angeliki G. Vittoraki John Bokos Smaragdi Marinaki Ioannis N. Boletis |
| author_sort | Maria Darema |
| collection | DOAJ |
| description | The Kidney Donor Risk Index (KDRI) and Kidney Donor Profile Index (KDPI) have been developed to assess deceased-donor graft quality, although validation of their utility outside the USA remains limited. This single-center retrospective cohort study evaluated the ability of KDRI and KDPI to predict transplant outcomes in a Greek cohort. The efficacy of KDRI, KDPI, and donor’s age in predicting death-censored graft failure was primarily assessed. Overall, 394 donors and 456 recipients were included. Death-censored graft survival was significantly worse with increasing KDRI (hazard ratio—HR: 2.21, 95% confidence intervals—CI: 1.16–4.22), KDPI (HR: 1.01, 95% CI: 1.00–1.02), and donor’s age (HR: 1.03, 95% CI: 1.00–1.05). The unadjusted discriminative ability was similar for KDPI (C-statistic: 0.54) and donor’s age (C-statistic: 0.52). The KDPI threshold of 85 was not predictive of graft failure (<i>p</i>-value: 0.19). Higher KDPI was linked to delayed graft function and worse kidney function, but not among expanded-criteria donor transplantations. No significant association was found between KDRI, KDPI, and patient survival. In conclusion, increasing KDRI and KDPI are linked to worse graft function, although their ability to discriminate long-term graft failure remains limited. |
| first_indexed | 2024-03-11T06:21:56Z |
| format | Article |
| id | doaj.art-3e9cd831c37a460bbf7ff476cfb78a33 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T06:21:56Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-3e9cd831c37a460bbf7ff476cfb78a332023-11-17T11:52:54ZengMDPI AGJournal of Clinical Medicine2077-03832023-03-01126243910.3390/jcm12062439Evaluation of Kidney Donor Risk Index/Kidney Donor Profile Index as Predictor Tools of Deceased-Donor Kidney Transplant Outcomes in a Greek CohortMaria Darema0Diamanto Athanasopoulou1Ioannis Bellos2Ioanna Tsoumbou3Angeliki G. Vittoraki4John Bokos5Smaragdi Marinaki6Ioannis N. Boletis7Department of Nephrology and Kidney Transplantation, Medical School, Laiko General Hospital of Athens, National and Kapodistrian University, 11527 Athens, GreeceDepartment of Nephrology and Kidney Transplantation, Medical School, Laiko General Hospital of Athens, National and Kapodistrian University, 11527 Athens, GreeceDepartment of Nephrology and Kidney Transplantation, Medical School, Laiko General Hospital of Athens, National and Kapodistrian University, 11527 Athens, GreeceDepartment of Nephrology and Kidney Transplantation, Medical School, Laiko General Hospital of Athens, National and Kapodistrian University, 11527 Athens, GreeceImmunology Department & National Tissue Typing Center, General Hospital of Athens “G. Gennimatas”, 11527 Athens, GreeceTransplantation Unit, Laiko General Hospital, 11527 Athens, GreeceDepartment of Nephrology and Kidney Transplantation, Medical School, Laiko General Hospital of Athens, National and Kapodistrian University, 11527 Athens, GreeceDepartment of Nephrology and Kidney Transplantation, Medical School, Laiko General Hospital of Athens, National and Kapodistrian University, 11527 Athens, GreeceThe Kidney Donor Risk Index (KDRI) and Kidney Donor Profile Index (KDPI) have been developed to assess deceased-donor graft quality, although validation of their utility outside the USA remains limited. This single-center retrospective cohort study evaluated the ability of KDRI and KDPI to predict transplant outcomes in a Greek cohort. The efficacy of KDRI, KDPI, and donor’s age in predicting death-censored graft failure was primarily assessed. Overall, 394 donors and 456 recipients were included. Death-censored graft survival was significantly worse with increasing KDRI (hazard ratio—HR: 2.21, 95% confidence intervals—CI: 1.16–4.22), KDPI (HR: 1.01, 95% CI: 1.00–1.02), and donor’s age (HR: 1.03, 95% CI: 1.00–1.05). The unadjusted discriminative ability was similar for KDPI (C-statistic: 0.54) and donor’s age (C-statistic: 0.52). The KDPI threshold of 85 was not predictive of graft failure (<i>p</i>-value: 0.19). Higher KDPI was linked to delayed graft function and worse kidney function, but not among expanded-criteria donor transplantations. No significant association was found between KDRI, KDPI, and patient survival. In conclusion, increasing KDRI and KDPI are linked to worse graft function, although their ability to discriminate long-term graft failure remains limited.https://www.mdpi.com/2077-0383/12/6/2439KDPIKDRIkidney transplantationdeceased-donorgraft survival |
| spellingShingle | Maria Darema Diamanto Athanasopoulou Ioannis Bellos Ioanna Tsoumbou Angeliki G. Vittoraki John Bokos Smaragdi Marinaki Ioannis N. Boletis Evaluation of Kidney Donor Risk Index/Kidney Donor Profile Index as Predictor Tools of Deceased-Donor Kidney Transplant Outcomes in a Greek Cohort Journal of Clinical Medicine KDPI KDRI kidney transplantation deceased-donor graft survival |
| title | Evaluation of Kidney Donor Risk Index/Kidney Donor Profile Index as Predictor Tools of Deceased-Donor Kidney Transplant Outcomes in a Greek Cohort |
| title_full | Evaluation of Kidney Donor Risk Index/Kidney Donor Profile Index as Predictor Tools of Deceased-Donor Kidney Transplant Outcomes in a Greek Cohort |
| title_fullStr | Evaluation of Kidney Donor Risk Index/Kidney Donor Profile Index as Predictor Tools of Deceased-Donor Kidney Transplant Outcomes in a Greek Cohort |
| title_full_unstemmed | Evaluation of Kidney Donor Risk Index/Kidney Donor Profile Index as Predictor Tools of Deceased-Donor Kidney Transplant Outcomes in a Greek Cohort |
| title_short | Evaluation of Kidney Donor Risk Index/Kidney Donor Profile Index as Predictor Tools of Deceased-Donor Kidney Transplant Outcomes in a Greek Cohort |
| title_sort | evaluation of kidney donor risk index kidney donor profile index as predictor tools of deceased donor kidney transplant outcomes in a greek cohort |
| topic | KDPI KDRI kidney transplantation deceased-donor graft survival |
| url | https://www.mdpi.com/2077-0383/12/6/2439 |
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