Antigenicity, Immunogenicity and Protective Efficacy of Three Proteins Expressed in the Promastigote and Amastigote Stages of Leishmania infantum against Visceral Leishmaniasis.

Antigenicity, Immunogenicity and Protective Efficacy of Three Proteins Expressed in the Promastigote and Amastigote Stages of Leishmania infantum against Visceral Leishmaniasis.

In the present study, two Leishmania infantum hypothetical proteins present in the amastigote stage, LiHyp1 and LiHyp6, were combined with a promastigote protein, IgE-dependent histamine-releasing factor (HRF); to compose a polyproteins vaccine to be evaluated against L. infantum infection. Also, th...

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Main Authors: Vivian Tamietti Martins, Miguel Angel Chávez-Fumagalli, Daniela Pagliara Lage, Mariana Costa Duarte, Esther Garde, Lourena Emanuele Costa, Viviane Grazielle da Silva, Jamil Silvano Oliveira, Danielle Ferreira de Magalhães-Soares, Santuza Maria Ribeiro Teixeira, Ana Paula Fernandes, Manuel Soto, Carlos Alberto Pereira Tavares, Eduardo Antonio Ferraz Coelho
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4569552?pdf=render

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