The 2-hydroxy-3-(4-aryl-1-piperazinyl)propyl Phthalimide Derivatives as Prodrugs—Spectroscopic and Theoretical Binding Studies with Plasma Proteins
Many publications in databases deal with the interactions of new drugs with albumin. However, it is not only albumin that is responsible for binding pharmaceutical molecules to proteins in the human body. There are many more proteins in plasma that are important for the study of the ADME pathway. Th...
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MDPI AG
2022-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/13/7003 |
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| author | Aleksandra Marciniak Aleksandra Kotynia Dominika Szkatuła Edward Krzyżak |
| author_facet | Aleksandra Marciniak Aleksandra Kotynia Dominika Szkatuła Edward Krzyżak |
| author_sort | Aleksandra Marciniak |
| collection | DOAJ |
| description | Many publications in databases deal with the interactions of new drugs with albumin. However, it is not only albumin that is responsible for binding pharmaceutical molecules to proteins in the human body. There are many more proteins in plasma that are important for the study of the ADME pathway. Therefore, in this study, we have shown the results of the interactions between the plasma proteins albumin, orosomucoid, and gamma globulins and non-toxic anti-inflammatory phthalimide analogs, which due to the promising obtained results, may be potential candidates in the group of analgesic and anti-inflammatory drugs. Using spectroscopic methods and molecular modeling, we showed that all four tested compounds form complexes with the analyzed proteins. The formation of a complex with proteins raises the pharmacological efficacy of the drug. Therefore, the obtained results could be a step in the study of the pharmacokinetics and pharmacodynamics of new potential pharmaceuticals. |
| first_indexed | 2024-03-09T21:51:39Z |
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| id | doaj.art-3ea156508d4d4129b649fd10758d9384 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T21:51:39Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-3ea156508d4d4129b649fd10758d93842023-11-23T20:06:13ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-06-012313700310.3390/ijms23137003The 2-hydroxy-3-(4-aryl-1-piperazinyl)propyl Phthalimide Derivatives as Prodrugs—Spectroscopic and Theoretical Binding Studies with Plasma ProteinsAleksandra Marciniak0Aleksandra Kotynia1Dominika Szkatuła2Edward Krzyżak3Department of Inorganic Chemistry, Wroclaw Medical University, ul. Borowska 211a, 50-556 Wrocław, PolandDepartment of Inorganic Chemistry, Wroclaw Medical University, ul. Borowska 211a, 50-556 Wrocław, PolandDepartment of Medicinal Chemistry, Wroclaw Medical University, ul. Borowska 211, 50-556 Wroclaw, PolandDepartment of Inorganic Chemistry, Wroclaw Medical University, ul. Borowska 211a, 50-556 Wrocław, PolandMany publications in databases deal with the interactions of new drugs with albumin. However, it is not only albumin that is responsible for binding pharmaceutical molecules to proteins in the human body. There are many more proteins in plasma that are important for the study of the ADME pathway. Therefore, in this study, we have shown the results of the interactions between the plasma proteins albumin, orosomucoid, and gamma globulins and non-toxic anti-inflammatory phthalimide analogs, which due to the promising obtained results, may be potential candidates in the group of analgesic and anti-inflammatory drugs. Using spectroscopic methods and molecular modeling, we showed that all four tested compounds form complexes with the analyzed proteins. The formation of a complex with proteins raises the pharmacological efficacy of the drug. Therefore, the obtained results could be a step in the study of the pharmacokinetics and pharmacodynamics of new potential pharmaceuticals.https://www.mdpi.com/1422-0067/23/13/7003plasma proteinsspectroscopic methodsphthalimide analogsphthalimide derivativesmolecular docking |
| spellingShingle | Aleksandra Marciniak Aleksandra Kotynia Dominika Szkatuła Edward Krzyżak The 2-hydroxy-3-(4-aryl-1-piperazinyl)propyl Phthalimide Derivatives as Prodrugs—Spectroscopic and Theoretical Binding Studies with Plasma Proteins International Journal of Molecular Sciences plasma proteins spectroscopic methods phthalimide analogs phthalimide derivatives molecular docking |
| title | The 2-hydroxy-3-(4-aryl-1-piperazinyl)propyl Phthalimide Derivatives as Prodrugs—Spectroscopic and Theoretical Binding Studies with Plasma Proteins |
| title_full | The 2-hydroxy-3-(4-aryl-1-piperazinyl)propyl Phthalimide Derivatives as Prodrugs—Spectroscopic and Theoretical Binding Studies with Plasma Proteins |
| title_fullStr | The 2-hydroxy-3-(4-aryl-1-piperazinyl)propyl Phthalimide Derivatives as Prodrugs—Spectroscopic and Theoretical Binding Studies with Plasma Proteins |
| title_full_unstemmed | The 2-hydroxy-3-(4-aryl-1-piperazinyl)propyl Phthalimide Derivatives as Prodrugs—Spectroscopic and Theoretical Binding Studies with Plasma Proteins |
| title_short | The 2-hydroxy-3-(4-aryl-1-piperazinyl)propyl Phthalimide Derivatives as Prodrugs—Spectroscopic and Theoretical Binding Studies with Plasma Proteins |
| title_sort | 2 hydroxy 3 4 aryl 1 piperazinyl propyl phthalimide derivatives as prodrugs spectroscopic and theoretical binding studies with plasma proteins |
| topic | plasma proteins spectroscopic methods phthalimide analogs phthalimide derivatives molecular docking |
| url | https://www.mdpi.com/1422-0067/23/13/7003 |
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