Prognosis of Regenerative Endodontic Procedures in Mature Teeth: A Systematic Review and Meta-Analysis of Clinical and Radiographic Parameters
This work aimed to investigate the use of Regenerative Endodontic Procedures (REP) on the treatment of pulp necrosis in mature teeth through systematic review and meta-analysis of evidence on clinical and radiographic parameters before and after REP. A search was performed in different databases on...
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| Format: | Article |
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MDPI AG
2021-08-01
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| Online Access: | https://www.mdpi.com/1996-1944/14/16/4418 |
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| author | Pantaleo Scelza Fabiano Gonçalves Isleine Caldas Fernanda Nunes Emanuelle Stellet Lourenço Sandro Tavares Marcela Magno Andrea Pintor Pietro Montemezzi Emanuele Di Edoardo Carlos Fernando de Almeida Barros Mourão Gutemberg Alves Miriam Zaccaro Scelza |
| author_facet | Pantaleo Scelza Fabiano Gonçalves Isleine Caldas Fernanda Nunes Emanuelle Stellet Lourenço Sandro Tavares Marcela Magno Andrea Pintor Pietro Montemezzi Emanuele Di Edoardo Carlos Fernando de Almeida Barros Mourão Gutemberg Alves Miriam Zaccaro Scelza |
| author_sort | Pantaleo Scelza |
| collection | DOAJ |
| description | This work aimed to investigate the use of Regenerative Endodontic Procedures (REP) on the treatment of pulp necrosis in mature teeth through systematic review and meta-analysis of evidence on clinical and radiographic parameters before and after REP. A search was performed in different databases on 9 September 2020, including seven clinical studies and randomized controlled trials (RCT). The methodological quality was assessed using Revised Cochrane risk-of-bias (RoB 2) and Before-and-After tools. Meta-analyses were performed to evaluate the success incidences regarding the reduction of periapical lesion and recovery of sensitivity. The certainty of the evidence was assessed using GRADE. Meta-analysis showed a high overall success of 0.95 (0.92, 0.98) I<sup>2</sup> = 6%, with high periapical lesion reduction at 12 months (0.93 (0.86, 0.96) I<sup>2</sup> = 37%) and by the end of follow-up (0.91 (0.83, 0.96) I<sup>2</sup> = 13%). Lower incidences of positive sensitivity response were identified for the electrical (0.58 (0.46, 0.70) I<sup>2</sup> = 51%) and cold tests (0.70 (0.54, 0.84) I<sup>2</sup> = 68%). The calculated levels of REP success were similar to those reported for immature teeth. With a very low certainty of evidence, the meta-analysis showed a high incidence of REP’s success for mature teeth with necrotic pulp evidenced by periapical lesion reduction and moderate positive responses to sensitivity tests. |
| first_indexed | 2024-03-10T08:38:56Z |
| format | Article |
| id | doaj.art-3ea20a3f345b44389c431455ff3edffe |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-10T08:38:56Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-3ea20a3f345b44389c431455ff3edffe2023-11-22T08:27:12ZengMDPI AGMaterials1996-19442021-08-011416441810.3390/ma14164418Prognosis of Regenerative Endodontic Procedures in Mature Teeth: A Systematic Review and Meta-Analysis of Clinical and Radiographic ParametersPantaleo Scelza0Fabiano Gonçalves1Isleine Caldas2Fernanda Nunes3Emanuelle Stellet Lourenço4Sandro Tavares5Marcela Magno6Andrea Pintor7Pietro Montemezzi8Emanuele Di Edoardo9Carlos Fernando de Almeida Barros Mourão10Gutemberg Alves11Miriam Zaccaro Scelza12Geriatric Dentistry Department, Universidade Federal Fluminense, Niterói 24020-140, RJ, BrazilPost-Graduate Program in Dentistry, Universidade Federal Fluminense, Niterói 24020-140, RJ, BrazilGeriatric Dentistry Department, Universidade Federal Fluminense, Niterói 24020-140, RJ, BrazilGeriatric Dentistry Department, Universidade Federal Fluminense, Niterói 24020-140, RJ, BrazilPost-Graduate Program in Dentistry, Universidade Federal Fluminense, Niterói 24020-140, RJ, BrazilPost-Graduate Program in Dentistry, Universidade Federal Fluminense, Niterói 24020-140, RJ, BrazilDepartment of Pediatric Dentistry and Orthodontics, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, BrazilDepartment of Pediatric Dentistry and Orthodontics, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, BrazilIndependent Researcher, 24128 Bergamo, ItalyIndependent Researcher, 20100 Milan, ItalyClinical Research Unit of the Antonio Pedro Hospital, Universidade Federal Fluminense, Niterói 24033-900, RJ, BrazilClinical Research Unit of the Antonio Pedro Hospital, Universidade Federal Fluminense, Niterói 24033-900, RJ, BrazilLaboratory of Experimental Culture Cell (LECCel), Department of Endodontics, Faculty of Dentistry, Universidade Federal Fluminense, Niterói 24020-140, RJ, BrazilThis work aimed to investigate the use of Regenerative Endodontic Procedures (REP) on the treatment of pulp necrosis in mature teeth through systematic review and meta-analysis of evidence on clinical and radiographic parameters before and after REP. A search was performed in different databases on 9 September 2020, including seven clinical studies and randomized controlled trials (RCT). The methodological quality was assessed using Revised Cochrane risk-of-bias (RoB 2) and Before-and-After tools. Meta-analyses were performed to evaluate the success incidences regarding the reduction of periapical lesion and recovery of sensitivity. The certainty of the evidence was assessed using GRADE. Meta-analysis showed a high overall success of 0.95 (0.92, 0.98) I<sup>2</sup> = 6%, with high periapical lesion reduction at 12 months (0.93 (0.86, 0.96) I<sup>2</sup> = 37%) and by the end of follow-up (0.91 (0.83, 0.96) I<sup>2</sup> = 13%). Lower incidences of positive sensitivity response were identified for the electrical (0.58 (0.46, 0.70) I<sup>2</sup> = 51%) and cold tests (0.70 (0.54, 0.84) I<sup>2</sup> = 68%). The calculated levels of REP success were similar to those reported for immature teeth. With a very low certainty of evidence, the meta-analysis showed a high incidence of REP’s success for mature teeth with necrotic pulp evidenced by periapical lesion reduction and moderate positive responses to sensitivity tests.https://www.mdpi.com/1996-1944/14/16/4418dentitionpermanentmeta-analysisregenerative endodonticssystematic review |
| spellingShingle | Pantaleo Scelza Fabiano Gonçalves Isleine Caldas Fernanda Nunes Emanuelle Stellet Lourenço Sandro Tavares Marcela Magno Andrea Pintor Pietro Montemezzi Emanuele Di Edoardo Carlos Fernando de Almeida Barros Mourão Gutemberg Alves Miriam Zaccaro Scelza Prognosis of Regenerative Endodontic Procedures in Mature Teeth: A Systematic Review and Meta-Analysis of Clinical and Radiographic Parameters Materials dentition permanent meta-analysis regenerative endodontics systematic review |
| title | Prognosis of Regenerative Endodontic Procedures in Mature Teeth: A Systematic Review and Meta-Analysis of Clinical and Radiographic Parameters |
| title_full | Prognosis of Regenerative Endodontic Procedures in Mature Teeth: A Systematic Review and Meta-Analysis of Clinical and Radiographic Parameters |
| title_fullStr | Prognosis of Regenerative Endodontic Procedures in Mature Teeth: A Systematic Review and Meta-Analysis of Clinical and Radiographic Parameters |
| title_full_unstemmed | Prognosis of Regenerative Endodontic Procedures in Mature Teeth: A Systematic Review and Meta-Analysis of Clinical and Radiographic Parameters |
| title_short | Prognosis of Regenerative Endodontic Procedures in Mature Teeth: A Systematic Review and Meta-Analysis of Clinical and Radiographic Parameters |
| title_sort | prognosis of regenerative endodontic procedures in mature teeth a systematic review and meta analysis of clinical and radiographic parameters |
| topic | dentition permanent meta-analysis regenerative endodontics systematic review |
| url | https://www.mdpi.com/1996-1944/14/16/4418 |
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