Acupoint Catgut Embedding Improves Lipid Metabolism in Exercise-Induced Fatigue Rats via the PPAR Signaling Pathway
To improve the phenomenon of exercise-induced fatigue that often occurs during horse racing, we previously studied the improvement in exercise tolerance by acupoint catgut embedding preconditioning in an exercise-induced fatigue rat model. We found that acupoint catgut embedding pretreatment effecti...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2023-02-01
|
Series: | Animals |
Subjects: | |
Online Access: | https://www.mdpi.com/2076-2615/13/4/558 |
_version_ | 1797622832258088960 |
---|---|
author | Yue Song Xiaoyu Shi Zhenzhen Gao Ran Li Jiamin Tian Xiaodong Cao Bin Yang Shihua Zhao Ying Yang |
author_facet | Yue Song Xiaoyu Shi Zhenzhen Gao Ran Li Jiamin Tian Xiaodong Cao Bin Yang Shihua Zhao Ying Yang |
author_sort | Yue Song |
collection | DOAJ |
description | To improve the phenomenon of exercise-induced fatigue that often occurs during horse racing, we previously studied the improvement in exercise tolerance by acupoint catgut embedding preconditioning in an exercise-induced fatigue rat model. We found that acupoint catgut embedding pretreatment effectively improved animal exercise tolerance. Here, by combining transcriptomics and metabolomics, we aimed to explore the underlying mechanisms of this improvement. We used blood biochemical detection combined with ELISA to detect triglyceride (TG), total cholesterol (TC), lactate dehydrogenase (LDH), high-density lipoprotein (HDL), alanine transaminase (ALT), aspartate aminotransferase (AST), and glucose (GLU), arachidonic acid (AA), and free fatty acid (FFA) content and found that acupoint embedding can correct FFA, AA, TG, LDH, and AST in the blood. We used RT-qPCR to measure the expression of genes in tissue from the quadriceps femoris muscle. We found that solute carrier family 27 member 2 (<i>Slc27a2)</i>, fatty acid binding protein 1 (<i>Fabp1)</i>, apolipoprotein C3 (<i>Apoc3)</i>, and lipoprotein lipase (<i>Lpl)</i> genes in the peroxisome proliferator-activated receptor (PPAR) signaling pathway were important. The regulation of lipid metabolism through the PPAR signaling pathway was important for improving the exercise endurance of rats in our exercise-induced fatigue model. Therefore, we conclude that acupoint catgut embedding can not only promote body fat decomposition and reduce lactic acid accumulation but also promote the repair of tissue damage and liver damage caused by exercise fatigue. Acupoint catgut embedding regulates the PPAR signaling pathway by upregulating <i>Lpl</i> expression and downregulating <i>Slc27a2</i>, <i>Fabp1</i>, and <i>Apoc3</i> expression to further improve body fat metabolism. |
first_indexed | 2024-03-11T09:15:51Z |
format | Article |
id | doaj.art-3ea514779cc84e40846266bc592454b7 |
institution | Directory Open Access Journal |
issn | 2076-2615 |
language | English |
last_indexed | 2024-03-11T09:15:51Z |
publishDate | 2023-02-01 |
publisher | MDPI AG |
record_format | Article |
series | Animals |
spelling | doaj.art-3ea514779cc84e40846266bc592454b72023-11-16T18:38:14ZengMDPI AGAnimals2076-26152023-02-0113455810.3390/ani13040558Acupoint Catgut Embedding Improves Lipid Metabolism in Exercise-Induced Fatigue Rats via the PPAR Signaling PathwayYue Song0Xiaoyu Shi1Zhenzhen Gao2Ran Li3Jiamin Tian4Xiaodong Cao5Bin Yang6Shihua Zhao7Ying Yang8College of Veterinary, Inner Mongolia Agricultural University, Hohhot 010018, ChinaCollege of Veterinary, Inner Mongolia Agricultural University, Hohhot 010018, ChinaCollege of Veterinary, Inner Mongolia Agricultural University, Hohhot 010018, ChinaCollege of Veterinary, Inner Mongolia Agricultural University, Hohhot 010018, ChinaCollege of Veterinary, Inner Mongolia Agricultural University, Hohhot 010018, ChinaSchool of Pharmacy, Inner Mongolia Medical University, Hohhot 010018, ChinaVeterinary Research Institute, Inner Mongolia Academy of Agricultural & Animal Husbandry Sciences, Hohhot 010031, ChinaVeterinary Research Institute, Inner Mongolia Academy of Agricultural & Animal Husbandry Sciences, Hohhot 010031, ChinaCollege of Veterinary, Inner Mongolia Agricultural University, Hohhot 010018, ChinaTo improve the phenomenon of exercise-induced fatigue that often occurs during horse racing, we previously studied the improvement in exercise tolerance by acupoint catgut embedding preconditioning in an exercise-induced fatigue rat model. We found that acupoint catgut embedding pretreatment effectively improved animal exercise tolerance. Here, by combining transcriptomics and metabolomics, we aimed to explore the underlying mechanisms of this improvement. We used blood biochemical detection combined with ELISA to detect triglyceride (TG), total cholesterol (TC), lactate dehydrogenase (LDH), high-density lipoprotein (HDL), alanine transaminase (ALT), aspartate aminotransferase (AST), and glucose (GLU), arachidonic acid (AA), and free fatty acid (FFA) content and found that acupoint embedding can correct FFA, AA, TG, LDH, and AST in the blood. We used RT-qPCR to measure the expression of genes in tissue from the quadriceps femoris muscle. We found that solute carrier family 27 member 2 (<i>Slc27a2)</i>, fatty acid binding protein 1 (<i>Fabp1)</i>, apolipoprotein C3 (<i>Apoc3)</i>, and lipoprotein lipase (<i>Lpl)</i> genes in the peroxisome proliferator-activated receptor (PPAR) signaling pathway were important. The regulation of lipid metabolism through the PPAR signaling pathway was important for improving the exercise endurance of rats in our exercise-induced fatigue model. Therefore, we conclude that acupoint catgut embedding can not only promote body fat decomposition and reduce lactic acid accumulation but also promote the repair of tissue damage and liver damage caused by exercise fatigue. Acupoint catgut embedding regulates the PPAR signaling pathway by upregulating <i>Lpl</i> expression and downregulating <i>Slc27a2</i>, <i>Fabp1</i>, and <i>Apoc3</i> expression to further improve body fat metabolism.https://www.mdpi.com/2076-2615/13/4/558transcriptomemetabolomeratexercise-induced fatigue |
spellingShingle | Yue Song Xiaoyu Shi Zhenzhen Gao Ran Li Jiamin Tian Xiaodong Cao Bin Yang Shihua Zhao Ying Yang Acupoint Catgut Embedding Improves Lipid Metabolism in Exercise-Induced Fatigue Rats via the PPAR Signaling Pathway Animals transcriptome metabolome rat exercise-induced fatigue |
title | Acupoint Catgut Embedding Improves Lipid Metabolism in Exercise-Induced Fatigue Rats via the PPAR Signaling Pathway |
title_full | Acupoint Catgut Embedding Improves Lipid Metabolism in Exercise-Induced Fatigue Rats via the PPAR Signaling Pathway |
title_fullStr | Acupoint Catgut Embedding Improves Lipid Metabolism in Exercise-Induced Fatigue Rats via the PPAR Signaling Pathway |
title_full_unstemmed | Acupoint Catgut Embedding Improves Lipid Metabolism in Exercise-Induced Fatigue Rats via the PPAR Signaling Pathway |
title_short | Acupoint Catgut Embedding Improves Lipid Metabolism in Exercise-Induced Fatigue Rats via the PPAR Signaling Pathway |
title_sort | acupoint catgut embedding improves lipid metabolism in exercise induced fatigue rats via the ppar signaling pathway |
topic | transcriptome metabolome rat exercise-induced fatigue |
url | https://www.mdpi.com/2076-2615/13/4/558 |
work_keys_str_mv | AT yuesong acupointcatgutembeddingimproveslipidmetabolisminexerciseinducedfatigueratsviathepparsignalingpathway AT xiaoyushi acupointcatgutembeddingimproveslipidmetabolisminexerciseinducedfatigueratsviathepparsignalingpathway AT zhenzhengao acupointcatgutembeddingimproveslipidmetabolisminexerciseinducedfatigueratsviathepparsignalingpathway AT ranli acupointcatgutembeddingimproveslipidmetabolisminexerciseinducedfatigueratsviathepparsignalingpathway AT jiamintian acupointcatgutembeddingimproveslipidmetabolisminexerciseinducedfatigueratsviathepparsignalingpathway AT xiaodongcao acupointcatgutembeddingimproveslipidmetabolisminexerciseinducedfatigueratsviathepparsignalingpathway AT binyang acupointcatgutembeddingimproveslipidmetabolisminexerciseinducedfatigueratsviathepparsignalingpathway AT shihuazhao acupointcatgutembeddingimproveslipidmetabolisminexerciseinducedfatigueratsviathepparsignalingpathway AT yingyang acupointcatgutembeddingimproveslipidmetabolisminexerciseinducedfatigueratsviathepparsignalingpathway |