Development of novel biliary metal stent with coil-spring structure and its application in vivo swine biliary stricture model
BackgroundAs of date, endoscopic biliary stenting with plastic stent (PS) and self-expandable metal stent (SEMS) have been widely used for the palliation of biliary tract strictures. However, these two stents have several limitations regarding the management of biliary strictures caused by intrahepa...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1103217/full |
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| author | In Rae Cho Sang Hyub Lee Jin Ho Choi Namyoung Park Min Woo Lee Joo Seong Kim Seok Jeong Seok Jeong Don Haeng Lee Don Haeng Lee Tae-Won Jeong Byoung-Yun Ki Woo Hyun Paik Ji Kon Ryu Yong-Tae Kim |
| author_facet | In Rae Cho Sang Hyub Lee Jin Ho Choi Namyoung Park Min Woo Lee Joo Seong Kim Seok Jeong Seok Jeong Don Haeng Lee Don Haeng Lee Tae-Won Jeong Byoung-Yun Ki Woo Hyun Paik Ji Kon Ryu Yong-Tae Kim |
| author_sort | In Rae Cho |
| collection | DOAJ |
| description | BackgroundAs of date, endoscopic biliary stenting with plastic stent (PS) and self-expandable metal stent (SEMS) have been widely used for the palliation of biliary tract strictures. However, these two stents have several limitations regarding the management of biliary strictures caused by intrahepatic and hilar cholangiocarcinoma. PS has short patency and also risks bile duct injury and bowel perforation. SEMS is difficult to revise when occluded by tumor overgrowth. To compensate for such shortcomings, we developed a novel biliary metal stent with coil-spring structure. The aim of this study was to investigate the feasibility and efficacy of the novel stent in a swine model.MethodsThe biliary stricture model was prepared in six mini-pigs using endobiliary radiofrequency ablation. Conventional PS (n=2) and novel stents (n=4) were deployed endoscopically. Technical success was defined as successful stent placement and clinical success was defined as >50% reduction of serum bilirubin level. Adverse events, stent migration, and endoscopic removability for one month after stenting were also assessed.ResultsThe biliary stricture was successfully created in all animals. The technical success rate was 100 %, and the clinical success rate was 50% in the PS group and 75% in the novel stent group. In the novel stent group, the median pre- and post-treatment serum bilirubin levels were 3.94 and 0.3 mg/dL. Stent migration occurred in two pigs and two stents were removed by endoscopy. There was no stent-related mortality.ConclusionsThe newly designed biliary metal stent was feasible and effective in a swine biliary stricture model. Further studies are needed to verify the usefulness of the novel stent in the management of biliary strictures. |
| first_indexed | 2024-04-10T09:40:39Z |
| format | Article |
| id | doaj.art-3ea5d637eb99490db6eaeddce5278e43 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-10T09:40:39Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-3ea5d637eb99490db6eaeddce5278e432023-02-17T10:33:00ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-02-011310.3389/fonc.2023.11032171103217Development of novel biliary metal stent with coil-spring structure and its application in vivo swine biliary stricture modelIn Rae Cho0Sang Hyub Lee1Jin Ho Choi2Namyoung Park3Min Woo Lee4Joo Seong Kim5Seok Jeong6Seok Jeong7Don Haeng Lee8Don Haeng Lee9Tae-Won Jeong10Byoung-Yun Ki11Woo Hyun Paik12Ji Kon Ryu13Yong-Tae Kim14Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Republic of KoreaDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Republic of KoreaDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Republic of KoreaDepartment of Gastroenterology, Kyung Hee University Hospital at Gangdong, Seoul, Republic of KoreaDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Republic of KoreaDepartment of Internal Medicine, Dongguk University College of Medicine, Dongguk University Ilsan Hospital, Goyang-si, Republic of KoreaDepartment of Internal Medicine, Dongguk University College of Medicine, Dongguk University Ilsan Hospital, Goyang-si, Republic of KoreaDigestive Disease Center, Department of Internal Medicine, Inha University School of Medicine, Incheon, Republic of KoreaDigestive Disease Center, Department of Internal Medicine, Inha University School of Medicine, Incheon, Republic of KoreaThe National Center of Efficacy Evaluation for the Development of Health Products Targeting Digestive Disorders (NCEED) and Utah-Inha DDS & Advanced Therapeutics Research Center, Incheon, Republic of KoreaThe National Center of Efficacy Evaluation for the Development of Health Products Targeting Digestive Disorders (NCEED) and Utah-Inha DDS & Advanced Therapeutics Research Center, Incheon, Republic of KoreaCG Bio Co., Ltd., Seoul, Republic of KoreaDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Republic of KoreaDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Republic of KoreaDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Republic of KoreaBackgroundAs of date, endoscopic biliary stenting with plastic stent (PS) and self-expandable metal stent (SEMS) have been widely used for the palliation of biliary tract strictures. However, these two stents have several limitations regarding the management of biliary strictures caused by intrahepatic and hilar cholangiocarcinoma. PS has short patency and also risks bile duct injury and bowel perforation. SEMS is difficult to revise when occluded by tumor overgrowth. To compensate for such shortcomings, we developed a novel biliary metal stent with coil-spring structure. The aim of this study was to investigate the feasibility and efficacy of the novel stent in a swine model.MethodsThe biliary stricture model was prepared in six mini-pigs using endobiliary radiofrequency ablation. Conventional PS (n=2) and novel stents (n=4) were deployed endoscopically. Technical success was defined as successful stent placement and clinical success was defined as >50% reduction of serum bilirubin level. Adverse events, stent migration, and endoscopic removability for one month after stenting were also assessed.ResultsThe biliary stricture was successfully created in all animals. The technical success rate was 100 %, and the clinical success rate was 50% in the PS group and 75% in the novel stent group. In the novel stent group, the median pre- and post-treatment serum bilirubin levels were 3.94 and 0.3 mg/dL. Stent migration occurred in two pigs and two stents were removed by endoscopy. There was no stent-related mortality.ConclusionsThe newly designed biliary metal stent was feasible and effective in a swine biliary stricture model. Further studies are needed to verify the usefulness of the novel stent in the management of biliary strictures.https://www.frontiersin.org/articles/10.3389/fonc.2023.1103217/fullendoscopic retrograde cholangiopancreatographybiliary tract neoplasmsbile duct obstructionstentanimal experiment |
| spellingShingle | In Rae Cho Sang Hyub Lee Jin Ho Choi Namyoung Park Min Woo Lee Joo Seong Kim Seok Jeong Seok Jeong Don Haeng Lee Don Haeng Lee Tae-Won Jeong Byoung-Yun Ki Woo Hyun Paik Ji Kon Ryu Yong-Tae Kim Development of novel biliary metal stent with coil-spring structure and its application in vivo swine biliary stricture model Frontiers in Oncology endoscopic retrograde cholangiopancreatography biliary tract neoplasms bile duct obstruction stent animal experiment |
| title | Development of novel biliary metal stent with coil-spring structure and its application in vivo swine biliary stricture model |
| title_full | Development of novel biliary metal stent with coil-spring structure and its application in vivo swine biliary stricture model |
| title_fullStr | Development of novel biliary metal stent with coil-spring structure and its application in vivo swine biliary stricture model |
| title_full_unstemmed | Development of novel biliary metal stent with coil-spring structure and its application in vivo swine biliary stricture model |
| title_short | Development of novel biliary metal stent with coil-spring structure and its application in vivo swine biliary stricture model |
| title_sort | development of novel biliary metal stent with coil spring structure and its application in vivo swine biliary stricture model |
| topic | endoscopic retrograde cholangiopancreatography biliary tract neoplasms bile duct obstruction stent animal experiment |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1103217/full |
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