Reactive astrogliosis in the era of single-cell transcriptomics
Reactive astrogliosis is a reaction of astrocytes to disturbed homeostasis in the central nervous system (CNS), accompanied by changes in astrocyte numbers, morphology, and function. Reactive astrocytes are important in the onset and progression of many neuropathologies, such as neurotrauma, stroke,...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2023.1173200/full |
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| author | Zuzana Matusova Zuzana Matusova Elly M. Hol Milos Pekny Milos Pekny Milos Pekny Mikael Kubista Mikael Kubista Lukas Valihrach Lukas Valihrach |
| author_facet | Zuzana Matusova Zuzana Matusova Elly M. Hol Milos Pekny Milos Pekny Milos Pekny Mikael Kubista Mikael Kubista Lukas Valihrach Lukas Valihrach |
| author_sort | Zuzana Matusova |
| collection | DOAJ |
| description | Reactive astrogliosis is a reaction of astrocytes to disturbed homeostasis in the central nervous system (CNS), accompanied by changes in astrocyte numbers, morphology, and function. Reactive astrocytes are important in the onset and progression of many neuropathologies, such as neurotrauma, stroke, and neurodegenerative diseases. Single-cell transcriptomics has revealed remarkable heterogeneity of reactive astrocytes, indicating their multifaceted functions in a whole spectrum of neuropathologies, with important temporal and spatial resolution, both in the brain and in the spinal cord. Interestingly, transcriptomic signatures of reactive astrocytes partially overlap between neurological diseases, suggesting shared and unique gene expression patterns in response to individual neuropathologies. In the era of single-cell transcriptomics, the number of new datasets steeply increases, and they often benefit from comparisons and integration with previously published work. Here, we provide an overview of reactive astrocyte populations defined by single-cell or single-nucleus transcriptomics across multiple neuropathologies, attempting to facilitate the search for relevant reference points and to improve the interpretability of new datasets containing cells with signatures of reactive astrocytes. |
| first_indexed | 2024-04-09T12:35:13Z |
| format | Article |
| id | doaj.art-3ea67e621fbb42a9837b204ab9c53b75 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-04-09T12:35:13Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-3ea67e621fbb42a9837b204ab9c53b752023-05-15T13:24:03ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022023-04-011710.3389/fncel.2023.11732001173200Reactive astrogliosis in the era of single-cell transcriptomicsZuzana Matusova0Zuzana Matusova1Elly M. Hol2Milos Pekny3Milos Pekny4Milos Pekny5Mikael Kubista6Mikael Kubista7Lukas Valihrach8Lukas Valihrach9Laboratory of Gene Expression, Institute of Biotechnology of the Czech Academy of Sciences, Vestec, CzechiaFaculty of Science, Charles University, Prague, CzechiaDepartment of Translational Neuroscience, University Medical Centre Utrecht Brain Centre, Utrecht University, Utrecht, NetherlandsLaboratory of Astrocyte Biology and CNS Regeneration, Center for Brain Repair, Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, SwedenFlorey Institute of Neuroscience and Mental Health, Parkville, VIC, AustraliaUniversity of Newcastle, Newcastle, NSW, AustraliaLaboratory of Gene Expression, Institute of Biotechnology of the Czech Academy of Sciences, Vestec, CzechiaTATAA Biocenter AB, Gothenburg, SwedenLaboratory of Gene Expression, Institute of Biotechnology of the Czech Academy of Sciences, Vestec, CzechiaDepartment of Cellular Neurophysiology, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, CzechiaReactive astrogliosis is a reaction of astrocytes to disturbed homeostasis in the central nervous system (CNS), accompanied by changes in astrocyte numbers, morphology, and function. Reactive astrocytes are important in the onset and progression of many neuropathologies, such as neurotrauma, stroke, and neurodegenerative diseases. Single-cell transcriptomics has revealed remarkable heterogeneity of reactive astrocytes, indicating their multifaceted functions in a whole spectrum of neuropathologies, with important temporal and spatial resolution, both in the brain and in the spinal cord. Interestingly, transcriptomic signatures of reactive astrocytes partially overlap between neurological diseases, suggesting shared and unique gene expression patterns in response to individual neuropathologies. In the era of single-cell transcriptomics, the number of new datasets steeply increases, and they often benefit from comparisons and integration with previously published work. Here, we provide an overview of reactive astrocyte populations defined by single-cell or single-nucleus transcriptomics across multiple neuropathologies, attempting to facilitate the search for relevant reference points and to improve the interpretability of new datasets containing cells with signatures of reactive astrocytes.https://www.frontiersin.org/articles/10.3389/fncel.2023.1173200/fullreactive astrogliosisastrocytescell populationssingle-cell RNA-seqneuroinflammationneurodegeneration |
| spellingShingle | Zuzana Matusova Zuzana Matusova Elly M. Hol Milos Pekny Milos Pekny Milos Pekny Mikael Kubista Mikael Kubista Lukas Valihrach Lukas Valihrach Reactive astrogliosis in the era of single-cell transcriptomics Frontiers in Cellular Neuroscience reactive astrogliosis astrocytes cell populations single-cell RNA-seq neuroinflammation neurodegeneration |
| title | Reactive astrogliosis in the era of single-cell transcriptomics |
| title_full | Reactive astrogliosis in the era of single-cell transcriptomics |
| title_fullStr | Reactive astrogliosis in the era of single-cell transcriptomics |
| title_full_unstemmed | Reactive astrogliosis in the era of single-cell transcriptomics |
| title_short | Reactive astrogliosis in the era of single-cell transcriptomics |
| title_sort | reactive astrogliosis in the era of single cell transcriptomics |
| topic | reactive astrogliosis astrocytes cell populations single-cell RNA-seq neuroinflammation neurodegeneration |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2023.1173200/full |
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