Bioactivities and Mechanisms of Action of Sinomenine and Its Derivatives: A Comprehensive Review
Sinomenine, an isoquinoline alkaloid extracted from the roots and stems of <i>Sinomenium acutum</i>, has been extensively studied for its derivatives as bioactive agents. This review concentrates on the research advancements in the biological activities and action mechanisms of sinomenin...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/29/2/540 |
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| author | Wen Hou Lejun Huang Hao Huang Shenglan Liu Wei Dai Jianhong Tang Xiangzhao Chen Xiaolu Lu Qisheng Zheng Zhinuo Zhou Ziyun Zhang Jinxia Lan |
| author_facet | Wen Hou Lejun Huang Hao Huang Shenglan Liu Wei Dai Jianhong Tang Xiangzhao Chen Xiaolu Lu Qisheng Zheng Zhinuo Zhou Ziyun Zhang Jinxia Lan |
| author_sort | Wen Hou |
| collection | DOAJ |
| description | Sinomenine, an isoquinoline alkaloid extracted from the roots and stems of <i>Sinomenium acutum</i>, has been extensively studied for its derivatives as bioactive agents. This review concentrates on the research advancements in the biological activities and action mechanisms of sinomenine-related compounds until November 2023. The findings indicate a broad spectrum of pharmacological effects, including antitumor, anti-inflammation, neuroprotection, and immunosuppressive properties. These compounds are notably effective against breast, lung, liver, and prostate cancers, exhibiting IC<sub>50</sub> values of approximately 121.4 nM against PC-3 and DU-145 cells, primarily through the PI3K/Akt/mTOR, NF-κB, MAPK, and JAK/STAT signaling pathways. Additionally, they manifest anti-inflammatory and analgesic effects predominantly via the NF-κB, MAPK, and Nrf2 signaling pathways. Utilized in treating rheumatic arthritis, these alkaloids also play a significant role in cardiovascular and cerebrovascular protection, as well as organ protection through the NF-κB, Nrf2, MAPK, and PI3K/Akt/mTOR signaling pathways. This review concludes with perspectives and insights on this topic, highlighting the potential of sinomenine-related compounds in clinical applications and the development of medications derived from natural products. |
| first_indexed | 2024-03-08T09:48:35Z |
| format | Article |
| id | doaj.art-3ea68b2ee08644ee9c2420976d6817db |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-08T09:48:35Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-3ea68b2ee08644ee9c2420976d6817db2024-01-29T14:09:26ZengMDPI AGMolecules1420-30492024-01-0129254010.3390/molecules29020540Bioactivities and Mechanisms of Action of Sinomenine and Its Derivatives: A Comprehensive ReviewWen Hou0Lejun Huang1Hao Huang2Shenglan Liu3Wei Dai4Jianhong Tang5Xiangzhao Chen6Xiaolu Lu7Qisheng Zheng8Zhinuo Zhou9Ziyun Zhang10Jinxia Lan11College of Pharmacy, Gannan Medical University, Ganzhou 341000, ChinaCollege of Rehabilitation, Gannan Medical University, Ganzhou 341000, ChinaCollege of Pharmacy, Gannan Medical University, Ganzhou 341000, ChinaCollege of Pharmacy, Gannan Medical University, Ganzhou 341000, ChinaCollege of Pharmacy, Gannan Medical University, Ganzhou 341000, ChinaLaboratory Animal Engineering Research Center of Ganzhou, Gannan Medical University, Ganzhou 341000, ChinaCollege of Pharmacy, Gannan Medical University, Ganzhou 341000, ChinaCollege of Pharmacy, Gannan Medical University, Ganzhou 341000, ChinaCollege of Pharmacy, Gannan Medical University, Ganzhou 341000, ChinaCollege of Pharmacy, Gannan Medical University, Ganzhou 341000, ChinaCollege of Pharmacy, Gannan Medical University, Ganzhou 341000, ChinaCollege of Public Health and Health Management, Gannan Medical University, Ganzhou 341000, ChinaSinomenine, an isoquinoline alkaloid extracted from the roots and stems of <i>Sinomenium acutum</i>, has been extensively studied for its derivatives as bioactive agents. This review concentrates on the research advancements in the biological activities and action mechanisms of sinomenine-related compounds until November 2023. The findings indicate a broad spectrum of pharmacological effects, including antitumor, anti-inflammation, neuroprotection, and immunosuppressive properties. These compounds are notably effective against breast, lung, liver, and prostate cancers, exhibiting IC<sub>50</sub> values of approximately 121.4 nM against PC-3 and DU-145 cells, primarily through the PI3K/Akt/mTOR, NF-κB, MAPK, and JAK/STAT signaling pathways. Additionally, they manifest anti-inflammatory and analgesic effects predominantly via the NF-κB, MAPK, and Nrf2 signaling pathways. Utilized in treating rheumatic arthritis, these alkaloids also play a significant role in cardiovascular and cerebrovascular protection, as well as organ protection through the NF-κB, Nrf2, MAPK, and PI3K/Akt/mTOR signaling pathways. This review concludes with perspectives and insights on this topic, highlighting the potential of sinomenine-related compounds in clinical applications and the development of medications derived from natural products.https://www.mdpi.com/1420-3049/29/2/540sinomeninederivativesantitumoranti-inflammatoryimmunosuppressiveneuroprotection |
| spellingShingle | Wen Hou Lejun Huang Hao Huang Shenglan Liu Wei Dai Jianhong Tang Xiangzhao Chen Xiaolu Lu Qisheng Zheng Zhinuo Zhou Ziyun Zhang Jinxia Lan Bioactivities and Mechanisms of Action of Sinomenine and Its Derivatives: A Comprehensive Review Molecules sinomenine derivatives antitumor anti-inflammatory immunosuppressive neuroprotection |
| title | Bioactivities and Mechanisms of Action of Sinomenine and Its Derivatives: A Comprehensive Review |
| title_full | Bioactivities and Mechanisms of Action of Sinomenine and Its Derivatives: A Comprehensive Review |
| title_fullStr | Bioactivities and Mechanisms of Action of Sinomenine and Its Derivatives: A Comprehensive Review |
| title_full_unstemmed | Bioactivities and Mechanisms of Action of Sinomenine and Its Derivatives: A Comprehensive Review |
| title_short | Bioactivities and Mechanisms of Action of Sinomenine and Its Derivatives: A Comprehensive Review |
| title_sort | bioactivities and mechanisms of action of sinomenine and its derivatives a comprehensive review |
| topic | sinomenine derivatives antitumor anti-inflammatory immunosuppressive neuroprotection |
| url | https://www.mdpi.com/1420-3049/29/2/540 |
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