CircCCDC66: Emerging roles and potential clinical values in malignant tumors
Circular RNAs (circRNAs) are endogenous non-coding RNAs (ncRNAs) with a closed-loop structure. In recent years, circRNAs have become the focus of much research into RNA. CircCCDC66 has been identified as a novel oncogenic circRNA and is up-regulated in a variety of malignant tumors including thyroid...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1061007/full |
| _version_ | 1797956862859018240 |
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| author | Xiaoxiao Wang Chao Zhang Huangqin Song Junlong Yuan Lei Zhang Lei Zhang Jiefeng He Jiefeng He |
| author_facet | Xiaoxiao Wang Chao Zhang Huangqin Song Junlong Yuan Lei Zhang Lei Zhang Jiefeng He Jiefeng He |
| author_sort | Xiaoxiao Wang |
| collection | DOAJ |
| description | Circular RNAs (circRNAs) are endogenous non-coding RNAs (ncRNAs) with a closed-loop structure. In recent years, circRNAs have become the focus of much research into RNA. CircCCDC66 has been identified as a novel oncogenic circRNA and is up-regulated in a variety of malignant tumors including thyroid cancer, non-small cell carcinoma, gastric cancer, colorectal cancer, renal cancer, cervical cancer, glioma, and osteosarcoma. It mediates cancer progression by regulating epigenetic modifications, variable splicing, transcription, and protein translation. The oncogenicity of circCCDC66 suppresses or promotes the expression of related genes mainly through direct or indirect pathways. This finding suggests that circCCDC66 is a biomarker for cancer diagnosis, prognosis assessment and treatment. However, there is no review on the relationship between circCCDC66 and cancers. Thus, the expression, biological functions, and regulatory mechanisms of circCCDC66 in malignant tumor and non-tumor diseases are summarized. The clinical value and prognostic significance of circCCDC66 are also evaluated, which can provide insights helpful to those exploring new strategies for the early diagnosis and targeted treatment of malignancies. |
| first_indexed | 2024-04-10T23:55:27Z |
| format | Article |
| id | doaj.art-3ea90cb8f289468b9cd74690d7895dee |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-10T23:55:27Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-3ea90cb8f289468b9cd74690d7895dee2023-01-10T13:25:16ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-01-011210.3389/fonc.2022.10610071061007CircCCDC66: Emerging roles and potential clinical values in malignant tumorsXiaoxiao Wang0Chao Zhang1Huangqin Song2Junlong Yuan3Lei Zhang4Lei Zhang5Jiefeng He6Jiefeng He7Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, ChinaThird Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, ChinaThird Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, ChinaThird Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, ChinaDepartment of Hepatobiliary Surgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, ChinaHepatic Surgery Center, Institute of Hepato-Pancreato-Biliary Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaThird Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, ChinaDepartment of Hepatobiliary Surgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, ChinaCircular RNAs (circRNAs) are endogenous non-coding RNAs (ncRNAs) with a closed-loop structure. In recent years, circRNAs have become the focus of much research into RNA. CircCCDC66 has been identified as a novel oncogenic circRNA and is up-regulated in a variety of malignant tumors including thyroid cancer, non-small cell carcinoma, gastric cancer, colorectal cancer, renal cancer, cervical cancer, glioma, and osteosarcoma. It mediates cancer progression by regulating epigenetic modifications, variable splicing, transcription, and protein translation. The oncogenicity of circCCDC66 suppresses or promotes the expression of related genes mainly through direct or indirect pathways. This finding suggests that circCCDC66 is a biomarker for cancer diagnosis, prognosis assessment and treatment. However, there is no review on the relationship between circCCDC66 and cancers. Thus, the expression, biological functions, and regulatory mechanisms of circCCDC66 in malignant tumor and non-tumor diseases are summarized. The clinical value and prognostic significance of circCCDC66 are also evaluated, which can provide insights helpful to those exploring new strategies for the early diagnosis and targeted treatment of malignancies.https://www.frontiersin.org/articles/10.3389/fonc.2022.1061007/fullcircular RNAcircCCDC66malignant tumorsendogenous competitive RNAregulatory mechanismcancer progression |
| spellingShingle | Xiaoxiao Wang Chao Zhang Huangqin Song Junlong Yuan Lei Zhang Lei Zhang Jiefeng He Jiefeng He CircCCDC66: Emerging roles and potential clinical values in malignant tumors Frontiers in Oncology circular RNA circCCDC66 malignant tumors endogenous competitive RNA regulatory mechanism cancer progression |
| title | CircCCDC66: Emerging roles and potential clinical values in malignant tumors |
| title_full | CircCCDC66: Emerging roles and potential clinical values in malignant tumors |
| title_fullStr | CircCCDC66: Emerging roles and potential clinical values in malignant tumors |
| title_full_unstemmed | CircCCDC66: Emerging roles and potential clinical values in malignant tumors |
| title_short | CircCCDC66: Emerging roles and potential clinical values in malignant tumors |
| title_sort | circccdc66 emerging roles and potential clinical values in malignant tumors |
| topic | circular RNA circCCDC66 malignant tumors endogenous competitive RNA regulatory mechanism cancer progression |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1061007/full |
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