An Efficacious Transgenic Strategy for Triple Knockout of Xeno-Reactive Antigen Genes GGTA1, CMAH, and B4GALNT2 from Jeju Native Pigs

An Efficacious Transgenic Strategy for Triple Knockout of Xeno-Reactive Antigen Genes GGTA1, CMAH, and B4GALNT2 from Jeju Native Pigs

Pigs are promising donors of biological materials for xenotransplantation; however, cell surface carbohydrate antigens, including galactose-alpha-1,3-galactose (α-Gal), N-glycolylneuraminic acid (Neu5Gc), and Sd blood group antigens, play a significant role in porcine xenograft rejection. Inactivati...

תיאור מלא

מידע ביבליוגרפי
Main Authors: Seungwon Yoon, Seulgi Lee, Chungyu Park, Hyunyong Choi, Minwoo Yoo, Sang Chul Lee, Cheol-Ho Hyun, Nameun Kim, Taeyoung Kang, Eugene Son, Mrinmoy Ghosh, Young-Ok Son, Chang-Gi Hur
פורמט: Article
שפה:English
יצא לאור: MDPI AG 2022-09-01
סדרה:Vaccines
נושאים:
CRISPR-CAS9 system
xenotransplantation
immune rejection
Jeju native pigs
גישה מקוונת:https://www.mdpi.com/2076-393X/10/9/1503

אינטרנט

https://www.mdpi.com/2076-393X/10/9/1503

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