A pan-cancer analysis for the oncogenic role of cyclin-dependent kinase inhibitor 1B in human cancers
Abstract Background Human health and life are threatened by cancer with high morbidity and mortality worldwide. In many experiments, CDKN1B level is associated with cancer risk, Nevertheless, no pan-cancer analysis has been conducted on CDKN1B in human cancers. Methods With the help of bioinformatic...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2023-07-01
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| Series: | Discover Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s12672-023-00746-8 |
| _version_ | 1797778823986544640 |
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| author | Hao Huang Duoliang Qiu Zhengyang Zhou Biaobiao Wu Lening Shao Yuwei Pu Tengfei He Yongyou Wu Dawei Cui Fengyun Zhong |
| author_facet | Hao Huang Duoliang Qiu Zhengyang Zhou Biaobiao Wu Lening Shao Yuwei Pu Tengfei He Yongyou Wu Dawei Cui Fengyun Zhong |
| author_sort | Hao Huang |
| collection | DOAJ |
| description | Abstract Background Human health and life are threatened by cancer with high morbidity and mortality worldwide. In many experiments, CDKN1B level is associated with cancer risk, Nevertheless, no pan-cancer analysis has been conducted on CDKN1B in human cancers. Methods With the help of bioinformatics, a pan-cancer analysis was conducted on the expression levels of CDKN1B in cancer tissues and adjacent tissues from the TCGA, CPTAC and GEO databases. The CDKN1B expression levels in tumor patients was further validated using immunohistochemistry (IHC) and quantitative real-time PCR. Results In the study, we first investigated the cancer-related roles of CDKN1B’s in 40 tumors with malignancy. The CDKN1B gene encodes the p27Kip1 protein, which can block the production cyclin-dependent kinase (CDK), which is obviously related to the function and survival of cancer cells and alters the prognosis of cancer patients. Furthermore, CDKN1B function requires both protein processing and RNA metabolism. Additionally, the elevated expression of the CDKN1B gene and protein was validated in several cancer tissues from the patients. Conclusions These results showed that the levels of CDKN1B were considerably different in a number of cancer tissues, offering a potential future target for cancer therapy. |
| first_indexed | 2024-03-12T23:22:06Z |
| format | Article |
| id | doaj.art-3eaf7f06cb94483b8db3663cfc443ac8 |
| institution | Directory Open Access Journal |
| issn | 2730-6011 |
| language | English |
| last_indexed | 2024-03-12T23:22:06Z |
| publishDate | 2023-07-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj.art-3eaf7f06cb94483b8db3663cfc443ac82023-07-16T11:20:22ZengSpringerDiscover Oncology2730-60112023-07-0114111510.1007/s12672-023-00746-8A pan-cancer analysis for the oncogenic role of cyclin-dependent kinase inhibitor 1B in human cancersHao Huang0Duoliang Qiu1Zhengyang Zhou2Biaobiao Wu3Lening Shao4Yuwei Pu5Tengfei He6Yongyou Wu7Dawei Cui8Fengyun Zhong9Department of General Surgery, The Second Affiliated Hospital of Soochow UniversityDepartment of General Surgery, The Second Affiliated Hospital of Soochow UniversityDepartment of General Surgery, The Second Affiliated Hospital of Soochow UniversityDepartment of General Surgery, The Second Affiliated Hospital of Soochow UniversityDepartment of General Surgery, The Second Affiliated Hospital of Soochow UniversityDepartment of General Surgery, The Second Affiliated Hospital of Soochow UniversityDepartment of General Surgery, The Second Affiliated Hospital of Soochow UniversityDepartment of General Surgery, The Second Affiliated Hospital of Soochow UniversityThe First Affiliated Hospital, Zhejiang University School of MedicineDepartment of General Surgery, The Second Affiliated Hospital of Soochow UniversityAbstract Background Human health and life are threatened by cancer with high morbidity and mortality worldwide. In many experiments, CDKN1B level is associated with cancer risk, Nevertheless, no pan-cancer analysis has been conducted on CDKN1B in human cancers. Methods With the help of bioinformatics, a pan-cancer analysis was conducted on the expression levels of CDKN1B in cancer tissues and adjacent tissues from the TCGA, CPTAC and GEO databases. The CDKN1B expression levels in tumor patients was further validated using immunohistochemistry (IHC) and quantitative real-time PCR. Results In the study, we first investigated the cancer-related roles of CDKN1B’s in 40 tumors with malignancy. The CDKN1B gene encodes the p27Kip1 protein, which can block the production cyclin-dependent kinase (CDK), which is obviously related to the function and survival of cancer cells and alters the prognosis of cancer patients. Furthermore, CDKN1B function requires both protein processing and RNA metabolism. Additionally, the elevated expression of the CDKN1B gene and protein was validated in several cancer tissues from the patients. Conclusions These results showed that the levels of CDKN1B were considerably different in a number of cancer tissues, offering a potential future target for cancer therapy.https://doi.org/10.1007/s12672-023-00746-8CDKN1BPan-cancerPrognosisCyclin-dependent kinaseGene |
| spellingShingle | Hao Huang Duoliang Qiu Zhengyang Zhou Biaobiao Wu Lening Shao Yuwei Pu Tengfei He Yongyou Wu Dawei Cui Fengyun Zhong A pan-cancer analysis for the oncogenic role of cyclin-dependent kinase inhibitor 1B in human cancers Discover Oncology CDKN1B Pan-cancer Prognosis Cyclin-dependent kinase Gene |
| title | A pan-cancer analysis for the oncogenic role of cyclin-dependent kinase inhibitor 1B in human cancers |
| title_full | A pan-cancer analysis for the oncogenic role of cyclin-dependent kinase inhibitor 1B in human cancers |
| title_fullStr | A pan-cancer analysis for the oncogenic role of cyclin-dependent kinase inhibitor 1B in human cancers |
| title_full_unstemmed | A pan-cancer analysis for the oncogenic role of cyclin-dependent kinase inhibitor 1B in human cancers |
| title_short | A pan-cancer analysis for the oncogenic role of cyclin-dependent kinase inhibitor 1B in human cancers |
| title_sort | pan cancer analysis for the oncogenic role of cyclin dependent kinase inhibitor 1b in human cancers |
| topic | CDKN1B Pan-cancer Prognosis Cyclin-dependent kinase Gene |
| url | https://doi.org/10.1007/s12672-023-00746-8 |
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