Prognostic significance of derived neutrophil-lymphocyte ratio in Non-metastatic breast cancer
Aim: Breast cancer is the most frequent cancer among women and the prognosis depends on the tumour biology and the treatment characteristics. Derived neutrophil-lymphocyte ratio (DNLR) a surrogate marker of cancer-associated inflammatory response is a cost-effective and simple prognostic parameter f...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Advances in Human Biology |
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| Online Access: | http://www.aihbonline.com/article.asp?issn=2321-8568;year=2017;volume=7;issue=2;spage=54;epage=60;aulast=Das |
| _version_ | 1798044359123271680 |
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| author | Chandan Krushna Das |
| author_facet | Chandan Krushna Das |
| author_sort | Chandan Krushna Das |
| collection | DOAJ |
| description | Aim: Breast cancer is the most frequent cancer among women and the prognosis depends on the tumour biology and the treatment characteristics. Derived neutrophil-lymphocyte ratio (DNLR) a surrogate marker of cancer-associated inflammatory response is a cost-effective and simple prognostic parameter for breast cancer. There is a paucity of data regarding the prognostic significance of the DNLR in breast cancer in Indian subcontinent. The aim of the study is to investigate the prognostic role of DNLR in breast cancer in the Indian population. Materials and Methods: 497 patient data were evaluated retrospectively for evaluation of DNLR as a prognostic marker in non-metastatic breast cancer. With a median time to follow-up is 33.8 months (range: 9.6-64.7). A total number of the relapse were 115 and 36 deaths occurred. Results: The predicted 5-year relapse free and overall survival were 70% and 87.5% respectively. On multivariate analyses, factors significantly associated with high DNLR were duration of presentation >6 month, pre-menopausal status, higher T stage, high leucocyte count and the presence of hypoalbuminemia. There was a significant association between DNLR with RFS and OS with P < 0.05 and 0.003 respectively. Conclusion: This is the first study to investigate the prognostic role of DNLR in breast cancer in the Indian population. With combination with other prognostic markers, DNLR, a low-cost, reliable marker of inflammation may have potential utility in breast cancer prognosis. |
| first_indexed | 2024-04-11T23:02:34Z |
| format | Article |
| id | doaj.art-3eaff90fa81c4bef896d06dda318b474 |
| institution | Directory Open Access Journal |
| issn | 2321-8568 2348-4691 |
| language | English |
| last_indexed | 2024-04-11T23:02:34Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Advances in Human Biology |
| spelling | doaj.art-3eaff90fa81c4bef896d06dda318b4742022-12-22T03:58:06ZengWolters Kluwer Medknow PublicationsAdvances in Human Biology2321-85682348-46912017-01-0172546010.4103/2321-8568.205387Prognostic significance of derived neutrophil-lymphocyte ratio in Non-metastatic breast cancerChandan Krushna DasAim: Breast cancer is the most frequent cancer among women and the prognosis depends on the tumour biology and the treatment characteristics. Derived neutrophil-lymphocyte ratio (DNLR) a surrogate marker of cancer-associated inflammatory response is a cost-effective and simple prognostic parameter for breast cancer. There is a paucity of data regarding the prognostic significance of the DNLR in breast cancer in Indian subcontinent. The aim of the study is to investigate the prognostic role of DNLR in breast cancer in the Indian population. Materials and Methods: 497 patient data were evaluated retrospectively for evaluation of DNLR as a prognostic marker in non-metastatic breast cancer. With a median time to follow-up is 33.8 months (range: 9.6-64.7). A total number of the relapse were 115 and 36 deaths occurred. Results: The predicted 5-year relapse free and overall survival were 70% and 87.5% respectively. On multivariate analyses, factors significantly associated with high DNLR were duration of presentation >6 month, pre-menopausal status, higher T stage, high leucocyte count and the presence of hypoalbuminemia. There was a significant association between DNLR with RFS and OS with P < 0.05 and 0.003 respectively. Conclusion: This is the first study to investigate the prognostic role of DNLR in breast cancer in the Indian population. With combination with other prognostic markers, DNLR, a low-cost, reliable marker of inflammation may have potential utility in breast cancer prognosis.http://www.aihbonline.com/article.asp?issn=2321-8568;year=2017;volume=7;issue=2;spage=54;epage=60;aulast=DasBreast cancerchemotherapyinflammationneutrophil-lymphocyte ratio |
| spellingShingle | Chandan Krushna Das Prognostic significance of derived neutrophil-lymphocyte ratio in Non-metastatic breast cancer Advances in Human Biology Breast cancer chemotherapy inflammation neutrophil-lymphocyte ratio |
| title | Prognostic significance of derived neutrophil-lymphocyte ratio in Non-metastatic breast cancer |
| title_full | Prognostic significance of derived neutrophil-lymphocyte ratio in Non-metastatic breast cancer |
| title_fullStr | Prognostic significance of derived neutrophil-lymphocyte ratio in Non-metastatic breast cancer |
| title_full_unstemmed | Prognostic significance of derived neutrophil-lymphocyte ratio in Non-metastatic breast cancer |
| title_short | Prognostic significance of derived neutrophil-lymphocyte ratio in Non-metastatic breast cancer |
| title_sort | prognostic significance of derived neutrophil lymphocyte ratio in non metastatic breast cancer |
| topic | Breast cancer chemotherapy inflammation neutrophil-lymphocyte ratio |
| url | http://www.aihbonline.com/article.asp?issn=2321-8568;year=2017;volume=7;issue=2;spage=54;epage=60;aulast=Das |
| work_keys_str_mv | AT chandankrushnadas prognosticsignificanceofderivedneutrophillymphocyteratioinnonmetastaticbreastcancer |