The compound TB47 is highly bactericidal against Mycobacterium ulcerans in a Buruli ulcer mouse model
Combination therapy for Buruli ulcer (BU) is suboptimal. Here, Liu et al. show that the candidate drug TB47 has potent bactericidal activity against Mycobacterium ulcerans in vitro and in a mouse model, which underscores its potential for shortening the course of BU and treating other mycobacterial...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2019-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-08464-y |
| _version_ | 1818433206586703872 |
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| author | Yang Liu Yamin Gao Jianxiong Liu Yaoju Tan Zhiyong Liu Chiranjibi Chhotaray Huofeng Jiang Zhili Lu Gift Chiwala Shuai Wang Gaelle Makafe Md Mahmudul Islam H. M. Adnan Hameed Xingshan Cai Changwei Wang Xinjie Li Shouyong Tan Tianyu Zhang |
| author_facet | Yang Liu Yamin Gao Jianxiong Liu Yaoju Tan Zhiyong Liu Chiranjibi Chhotaray Huofeng Jiang Zhili Lu Gift Chiwala Shuai Wang Gaelle Makafe Md Mahmudul Islam H. M. Adnan Hameed Xingshan Cai Changwei Wang Xinjie Li Shouyong Tan Tianyu Zhang |
| author_sort | Yang Liu |
| collection | DOAJ |
| description | Combination therapy for Buruli ulcer (BU) is suboptimal. Here, Liu et al. show that the candidate drug TB47 has potent bactericidal activity against Mycobacterium ulcerans in vitro and in a mouse model, which underscores its potential for shortening the course of BU and treating other mycobacterial diseases. |
| first_indexed | 2024-12-14T16:17:25Z |
| format | Article |
| id | doaj.art-3eb099eeaf12439699ea5255f9ccaab6 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T16:17:25Z |
| publishDate | 2019-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-3eb099eeaf12439699ea5255f9ccaab62022-12-21T22:54:53ZengNature PortfolioNature Communications2041-17232019-01-011011910.1038/s41467-019-08464-yThe compound TB47 is highly bactericidal against Mycobacterium ulcerans in a Buruli ulcer mouse modelYang Liu0Yamin Gao1Jianxiong Liu2Yaoju Tan3Zhiyong Liu4Chiranjibi Chhotaray5Huofeng Jiang6Zhili Lu7Gift Chiwala8Shuai Wang9Gaelle Makafe10Md Mahmudul Islam11H. M. Adnan Hameed12Xingshan Cai13Changwei Wang14Xinjie Li15Shouyong Tan16Tianyu Zhang17State Key Laboratory of Respiratory Disease, Guangzhou Regenerative Medicine and Health Guangdong Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences (CAS)State Key Laboratory of Respiratory Disease, Guangzhou Regenerative Medicine and Health Guangdong Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences (CAS)State Key Laboratory of Respiratory Disease, Department of Clinical Laboratory, Guangzhou Chest HospitalState Key Laboratory of Respiratory Disease, Department of Clinical Laboratory, Guangzhou Chest HospitalState Key Laboratory of Respiratory Disease, Guangzhou Regenerative Medicine and Health Guangdong Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences (CAS)State Key Laboratory of Respiratory Disease, Guangzhou Regenerative Medicine and Health Guangdong Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences (CAS)State Key Laboratory of Respiratory Disease, Guangzhou Regenerative Medicine and Health Guangdong Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences (CAS)State Key Laboratory of Respiratory Disease, Guangzhou Regenerative Medicine and Health Guangdong Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences (CAS)State Key Laboratory of Respiratory Disease, Guangzhou Regenerative Medicine and Health Guangdong Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences (CAS)State Key Laboratory of Respiratory Disease, Guangzhou Regenerative Medicine and Health Guangdong Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences (CAS)State Key Laboratory of Respiratory Disease, Guangzhou Regenerative Medicine and Health Guangdong Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences (CAS)State Key Laboratory of Respiratory Disease, Guangzhou Regenerative Medicine and Health Guangdong Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences (CAS)State Key Laboratory of Respiratory Disease, Guangzhou Regenerative Medicine and Health Guangdong Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences (CAS)State Key Laboratory of Respiratory Disease, Department of Clinical Laboratory, Guangzhou Chest HospitalState Key Laboratory of Respiratory Disease, Guangzhou Regenerative Medicine and Health Guangdong Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences (CAS)State Key Laboratory of Respiratory Disease, Department of Clinical Laboratory, Guangzhou Chest HospitalState Key Laboratory of Respiratory Disease, Department of Clinical Laboratory, Guangzhou Chest HospitalState Key Laboratory of Respiratory Disease, Guangzhou Regenerative Medicine and Health Guangdong Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences (CAS)Combination therapy for Buruli ulcer (BU) is suboptimal. Here, Liu et al. show that the candidate drug TB47 has potent bactericidal activity against Mycobacterium ulcerans in vitro and in a mouse model, which underscores its potential for shortening the course of BU and treating other mycobacterial diseases.https://doi.org/10.1038/s41467-019-08464-y |
| spellingShingle | Yang Liu Yamin Gao Jianxiong Liu Yaoju Tan Zhiyong Liu Chiranjibi Chhotaray Huofeng Jiang Zhili Lu Gift Chiwala Shuai Wang Gaelle Makafe Md Mahmudul Islam H. M. Adnan Hameed Xingshan Cai Changwei Wang Xinjie Li Shouyong Tan Tianyu Zhang The compound TB47 is highly bactericidal against Mycobacterium ulcerans in a Buruli ulcer mouse model Nature Communications |
| title | The compound TB47 is highly bactericidal against Mycobacterium ulcerans in a Buruli ulcer mouse model |
| title_full | The compound TB47 is highly bactericidal against Mycobacterium ulcerans in a Buruli ulcer mouse model |
| title_fullStr | The compound TB47 is highly bactericidal against Mycobacterium ulcerans in a Buruli ulcer mouse model |
| title_full_unstemmed | The compound TB47 is highly bactericidal against Mycobacterium ulcerans in a Buruli ulcer mouse model |
| title_short | The compound TB47 is highly bactericidal against Mycobacterium ulcerans in a Buruli ulcer mouse model |
| title_sort | compound tb47 is highly bactericidal against mycobacterium ulcerans in a buruli ulcer mouse model |
| url | https://doi.org/10.1038/s41467-019-08464-y |
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