Microvascular and Endothelial Dysfunction in Prediabetes
Prediabetes is a significant metabolic status since there is high potential for future progression of diabetes mellitus (DM). People with prediabetes are at increased risk of cardiovascular disease (CVD) and mortality. Endothelial and microvascular dysfunction is considered a key step towards the de...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/13/3/644 |
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| author | Stamatina Lamprou Nikolaos Koletsos Gesthimani Mintziori Panagiota Anyfanti Christina Trakatelli Vasileios Kotsis Eugenia Gkaliagkousi Areti Triantafyllou |
| author_facet | Stamatina Lamprou Nikolaos Koletsos Gesthimani Mintziori Panagiota Anyfanti Christina Trakatelli Vasileios Kotsis Eugenia Gkaliagkousi Areti Triantafyllou |
| author_sort | Stamatina Lamprou |
| collection | DOAJ |
| description | Prediabetes is a significant metabolic status since there is high potential for future progression of diabetes mellitus (DM). People with prediabetes are at increased risk of cardiovascular disease (CVD) and mortality. Endothelial and microvascular dysfunction is considered a key step towards the development and progression of CVD. Importantly, endothelial and microvascular dysfunction can be detected and monitored using non-invasive procedures in peripheral organs and tissues, including the retina, kidney, skin and skeletal muscle. Structural and functional alterations of the microvasculature have been consistently documented in the above microvascular beds in patients with diabetes mellitus. In contrast, such alterations remain understudied in prediabetes, but are currently receiving attention as markers of subclinical and future CVD. The aim of this review is to summarize available evidence regarding the presence of subclinical microvascular and endothelial dysfunction in prediabetes and their impact on cardiovascular risk. |
| first_indexed | 2024-03-11T06:17:05Z |
| format | Article |
| id | doaj.art-3eb151fbea644293bd50d7657b57db4f |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-11T06:17:05Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-3eb151fbea644293bd50d7657b57db4f2023-11-17T12:10:23ZengMDPI AGLife2075-17292023-02-0113364410.3390/life13030644Microvascular and Endothelial Dysfunction in PrediabetesStamatina Lamprou0Nikolaos Koletsos1Gesthimani Mintziori2Panagiota Anyfanti3Christina Trakatelli4Vasileios Kotsis5Eugenia Gkaliagkousi6Areti Triantafyllou7Third Department of Internal Medicine, Papageorgiou General Hospital, Aristotle University of Thessaloniki, 56429 Thessaloniki, GreeceThird Department of Internal Medicine, Papageorgiou General Hospital, Aristotle University of Thessaloniki, 56429 Thessaloniki, GreeceUnit of Reproductive Endocrinology, 1st Department of Obstetrics and Gynecology, Papageorgiou General Hospital, Aristotle University of Thessaloniki, 56429 Thessaloniki, GreeceSecond Medical Department, Hippokration Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, GreeceThird Department of Internal Medicine, Papageorgiou General Hospital, Aristotle University of Thessaloniki, 56429 Thessaloniki, GreeceThird Department of Internal Medicine, Papageorgiou General Hospital, Aristotle University of Thessaloniki, 56429 Thessaloniki, GreeceThird Department of Internal Medicine, Papageorgiou General Hospital, Aristotle University of Thessaloniki, 56429 Thessaloniki, GreeceThird Department of Internal Medicine, Papageorgiou General Hospital, Aristotle University of Thessaloniki, 56429 Thessaloniki, GreecePrediabetes is a significant metabolic status since there is high potential for future progression of diabetes mellitus (DM). People with prediabetes are at increased risk of cardiovascular disease (CVD) and mortality. Endothelial and microvascular dysfunction is considered a key step towards the development and progression of CVD. Importantly, endothelial and microvascular dysfunction can be detected and monitored using non-invasive procedures in peripheral organs and tissues, including the retina, kidney, skin and skeletal muscle. Structural and functional alterations of the microvasculature have been consistently documented in the above microvascular beds in patients with diabetes mellitus. In contrast, such alterations remain understudied in prediabetes, but are currently receiving attention as markers of subclinical and future CVD. The aim of this review is to summarize available evidence regarding the presence of subclinical microvascular and endothelial dysfunction in prediabetes and their impact on cardiovascular risk.https://www.mdpi.com/2075-1729/13/3/644prediabetesendothelial dysfunctioncardiovascular diseaseskin microcirculationretinopathymicroalbuminuria |
| spellingShingle | Stamatina Lamprou Nikolaos Koletsos Gesthimani Mintziori Panagiota Anyfanti Christina Trakatelli Vasileios Kotsis Eugenia Gkaliagkousi Areti Triantafyllou Microvascular and Endothelial Dysfunction in Prediabetes Life prediabetes endothelial dysfunction cardiovascular disease skin microcirculation retinopathy microalbuminuria |
| title | Microvascular and Endothelial Dysfunction in Prediabetes |
| title_full | Microvascular and Endothelial Dysfunction in Prediabetes |
| title_fullStr | Microvascular and Endothelial Dysfunction in Prediabetes |
| title_full_unstemmed | Microvascular and Endothelial Dysfunction in Prediabetes |
| title_short | Microvascular and Endothelial Dysfunction in Prediabetes |
| title_sort | microvascular and endothelial dysfunction in prediabetes |
| topic | prediabetes endothelial dysfunction cardiovascular disease skin microcirculation retinopathy microalbuminuria |
| url | https://www.mdpi.com/2075-1729/13/3/644 |
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