Intra-arterial chemotherapy in retinoblastoma – A paradigm change
Intra-arterial chemotherapy (IAC), also known as superselective ophthalmic artery chemotherapy or chemosurgery, is currently widely accepted as one of the primary treatment modalities for intraocular retinoblastoma worldwide. Following the introduction of the technique in 1998, IAC has evolved over...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Indian Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2019;volume=67;issue=6;spage=740;epage=754;aulast=Manjandavida |
| _version_ | 1818062707258032128 |
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| author | Fairooz P Manjandavida Christina Stathopoulos Jing Zhang Santhosh G Honavar Carol L Shields |
| author_facet | Fairooz P Manjandavida Christina Stathopoulos Jing Zhang Santhosh G Honavar Carol L Shields |
| author_sort | Fairooz P Manjandavida |
| collection | DOAJ |
| description | Intra-arterial chemotherapy (IAC), also known as superselective ophthalmic artery chemotherapy or chemosurgery, is currently widely accepted as one of the primary treatment modalities for intraocular retinoblastoma worldwide. Following the introduction of the technique in 1998, IAC has evolved over the past decades to be safer and more effective. Accumulated evidence shows that IAC is more effective in providing eye salvage in group D and E retinoblastoma as compared to conventional systemic intravenous chemotherapy (IVC). In contrast to IVC, IAC has the added benefits of reduced overall treatment duration and minimal systemic toxicity. This review provides a comprehensive update on the history, technique, indications, contraindications, and outcome of IAC. We have also identified the strengths, weaknesses, opportunities and threats (SWOT analysis) of the technique in this review. |
| first_indexed | 2024-12-10T14:08:29Z |
| format | Article |
| id | doaj.art-3eb1b0b5dc5c44908322b287cdc46912 |
| institution | Directory Open Access Journal |
| issn | 0301-4738 1998-3689 |
| language | English |
| last_indexed | 2024-12-10T14:08:29Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-3eb1b0b5dc5c44908322b287cdc469122022-12-22T01:45:34ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892019-01-0167674075410.4103/ijo.IJO_866_19Intra-arterial chemotherapy in retinoblastoma – A paradigm changeFairooz P ManjandavidaChristina StathopoulosJing ZhangSanthosh G HonavarCarol L ShieldsIntra-arterial chemotherapy (IAC), also known as superselective ophthalmic artery chemotherapy or chemosurgery, is currently widely accepted as one of the primary treatment modalities for intraocular retinoblastoma worldwide. Following the introduction of the technique in 1998, IAC has evolved over the past decades to be safer and more effective. Accumulated evidence shows that IAC is more effective in providing eye salvage in group D and E retinoblastoma as compared to conventional systemic intravenous chemotherapy (IVC). In contrast to IVC, IAC has the added benefits of reduced overall treatment duration and minimal systemic toxicity. This review provides a comprehensive update on the history, technique, indications, contraindications, and outcome of IAC. We have also identified the strengths, weaknesses, opportunities and threats (SWOT analysis) of the technique in this review.http://www.ijo.in/article.asp?issn=0301-4738;year=2019;volume=67;issue=6;spage=740;epage=754;aulast=ManjandavidaRetinoblastomaintra-arterial chemotherapyselective ophthalmic artery chemotherapysuperselective ophthalmic artery chemotherapychemosurgery |
| spellingShingle | Fairooz P Manjandavida Christina Stathopoulos Jing Zhang Santhosh G Honavar Carol L Shields Intra-arterial chemotherapy in retinoblastoma – A paradigm change Indian Journal of Ophthalmology Retinoblastoma intra-arterial chemotherapy selective ophthalmic artery chemotherapy superselective ophthalmic artery chemotherapy chemosurgery |
| title | Intra-arterial chemotherapy in retinoblastoma – A paradigm change |
| title_full | Intra-arterial chemotherapy in retinoblastoma – A paradigm change |
| title_fullStr | Intra-arterial chemotherapy in retinoblastoma – A paradigm change |
| title_full_unstemmed | Intra-arterial chemotherapy in retinoblastoma – A paradigm change |
| title_short | Intra-arterial chemotherapy in retinoblastoma – A paradigm change |
| title_sort | intra arterial chemotherapy in retinoblastoma a paradigm change |
| topic | Retinoblastoma intra-arterial chemotherapy selective ophthalmic artery chemotherapy superselective ophthalmic artery chemotherapy chemosurgery |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2019;volume=67;issue=6;spage=740;epage=754;aulast=Manjandavida |
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