Effect of Ku80 deficiency on mutation frequencies and spectra at a LacZ reporter locus in mouse tissues and cells.

Effect of Ku80 deficiency on mutation frequencies and spectra at a LacZ reporter locus in mouse tissues and cells.

Non-homologous end joining (NHEJ) is thought to be an important mechanism for preventing the adverse effects of DNA double strand breaks (DSBs) and its absence has been associated with premature aging. To investigate the effect of inactivated NHEJ on spontaneous mutation frequencies and spectra in v...

Full description

Bibliographic Details
Main Authors:	Rita A Busuttil, Denise P Muñoz, Ana Maria Garcia, Francis Rodier, Woo Ho Kim, Yousin Suh, Paul Hasty, Judith Campisi, Jan Vijg
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2008-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC2565499?pdf=render

Similar Items

The functional mutational landscape of the lacZ gene
by: Marc A. Beal, et al.
Published: (2023-12-01)

In trans regulation of the sgm::lacZ fusion
by: Miljković Marijana, et al.
Published: (2002-01-01)

LacZ siRNA and antisense DNA decrease beta-galactosidase mRNA but not protein expression in the airways of K18-lacZ transgenic mice
by: Griesenbach, U, et al.
Published: (2004)

Aspartoacylase-lacZ knockin mice: an engineered model of Canavan disease.
by: Nadine Mersmann, et al.
Published: (2011-01-01)

A structural view of the action of Escherichia coli (lacZ) beta-galactosidase.
by: Juers, D, et al.
Published: (2001)

[PROVISIONAL] Boundaries in metagenomic screenings using lacZα-based vectors
by: Luana de Fátima Alves, et al.

Tumorigenesis in mice with a fusion of the leukaemia oncogene Mll and the bacterial lacZ gene.
by: Dobson, C, et al.
Published: (2000)

Physiologically Aggregated LacZ Applied in Trehalose Galactosylation in a Recycled Batch Mode
by: Martina Belkova, et al.
Published: (2023-07-01)

Systemic RNAi delivery to the muscles of ROSA26 mice reduces lacZ expression.
by: Jessica Wei, et al.
Published: (2014-01-01)

Activatable Photosensitizer for Targeted Ablation of lacZ-Positive Cells with Single-Cell Resolution
by: Mayumi Chiba, et al.
Published: (2019-08-01)

Protocol to visualize CD11c+ cells in atherosclerosis using LacZ reporter mice
by: Manuela Sauter, et al.
Published: (2022-09-01)

Into the blue: the importance of murine lacZ gene expression profiling in understanding and treating human disease
by: Chris Armit
Published: (2015-11-01)

Production of LacZ inducible T cell hybridoma specific for human and mouse gp100₂₅₋₃₃ peptides.
by: Gal Cafri, et al.
Published: (2013-01-01)

Action of Photodynamic Therapy at Low Fluence in 9 L/lacZ Cells after Interaction with Chlorins
by: Gabrielle dos Santos Vitorio, et al.
Published: (2023-02-01)

Analysis of Dip2B Expression in Adult Mouse Tissues Using the LacZ Reporter Gene
by: Rajiv Kumar Sah, et al.
Published: (2021-06-01)

Construction of a RFP-lacZα bicistronic reporter system and its application in lead biosensing.
by: Chang-Ye Hui, et al.
Published: (2020-01-01)

A GFP-lacZ bicistronic reporter system for promoter analysis in environmental gram-negative bacteria.
by: Rafael Silva-Rocha, et al.
Published: (2012-01-01)

Expression of the Ly-6A (Sca-1) lacZ transgene in mouse haematopoietic stem cells and embryos.
by: Ma, X, et al.
Published: (2002)

Lethality of MalE-LacZ hybrid protein shares mechanistic attributes with oxidative component of antibiotic lethality
by: Liu, Xiaobo, et al.
Published: (2018)

Lentiviral Transfer of the LacZ Gene into Human Endothelial Cells and Human Bone Marrow Mesenchymal Stem Cells
by: Toshinori Totsugawa, et al.
Published: (2002-07-01)

Various mutations compensate for a deleterious lacZα insert in the replication enhancer of M13 bacteriophage.
by: Emily M Zygiel, et al.
Published: (2017-01-01)

The progeroid phenotype of Ku80 deficiency is dominant over DNA-PKCS deficiency.
by: Erwin Reiling, et al.
Published: (2014-01-01)

Optimized immunofluorescence staining protocol for identifying resident mesenchymal stem cells in bone using LacZ transgenic mice
by: Chen-Xi Zheng, et al.
Published: (2022-12-01)

Characterization of platelet-derived growth factor-A expression in mouse tissues using a lacZ knock-in approach.
by: Johanna Andrae, et al.
Published: (2014-01-01)

Contrasting expression of canonical Wnt signaling reporters TOPGAL, BATGAL and Axin2(LacZ) during murine lung development and repair.
by: Denise Al Alam, et al.
Published: (2011-01-01)

Expression of succinate dehydrogenase flavoprotein subunit in saccharomyces cerevisiae studied by lacZ reporter strategy. Effect of FLX1 deletion.
by: Giancaspero, T, et al.
Published: (2007)

Correction: Characterization of Platelet-Derived Growth Factor-A Expression in Mouse Tissues Using a lacZ Knock-In Approach
Published: (2014-01-01)

Correction: Characterization of Platelet-Derived Growth Factor-A Expression in Mouse Tissues Using a lacZ Knock-In Approach.
Published: (2014-01-01)

Evaluation of the toxic potential of aspartame in third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ) Bg9
by: YASIR HASAN SIDDIQUE, et al.
Published: (2017-07-01)

Beta-galactosidase staining in the nucleus of the solitary tract of Fos-Tau-LacZ mice is unaffected by monosodium glutamate taste stimulation.
by: Jennifer M Stratford, et al.
Published: (2014-01-01)

Hematopoietic Recovery after Transplantation CD117+B220- (lacZ+) Bone Marrow Cells in Lethally Irradiated Mice
by: Miroslav Hodek, et al.
Published: (2008-01-01)

Characterization of two β-galactosidases LacZ and WspA1 from Nostoc flagelliforme with focus on the latter’s central active region
by: Xiang Gao, et al.
Published: (2021-09-01)

Quantification of prefrontal cortical neuronal ensembles following conditioned fear learning in a Fos-LacZ transgenic rat with photoacoustic imaging in Vivo
by: James I. Matchynski, et al.
Published: (2023-10-01)

FAM19A5 Expression During Embryogenesis and in the Adult Traumatic Brain of FAM19A5-LacZ Knock-in Mice
by: Anu Shahapal, et al.
Published: (2019-08-01)

An MSC2 Promoter-lacZ Fusion Gene Reveals Zinc-Responsive Changes in Sites of Transcription Initiation That Occur across the Yeast Genome.
by: Yi-Hsuan Wu, et al.
Published: (2016-01-01)

Activation of LacZ gene in Escherichia coli DH5α via α-complementation mechanism for β-galactosidase production and its biochemical characterizations
by: Ahmed A. Hamed, et al.
Published: (2020-12-01)

AMBN mutations causing hypoplastic amelogenesis imperfecta and Ambn knockout‐NLS‐lacZ knockin mice exhibiting failed amelogenesis and Ambn tissue‐specificity
by: Tian Liang, et al.
Published: (2019-09-01)

Direct measurement of neuronal ensemble activity using photoacoustic imaging in the stimulated Fos-LacZ transgenic rat brain: A proof-of-principle study
by: James I. Matchynski, et al.
Published: (2021-12-01)

Correction: Evaluation of the Toxic Potential of Graphene Copper Nanocomposite (GCNC) in the Third Instar Larvae of Transgenic Drosophila melanogaster (hsp70-lacZ)Bg9
Published: (2014-01-01)

Differential Roles of Ku70 and Ku80 in the MMEJ Phenotype
by: Brideau, C, et al.
Published: (2012)