Study of cytokine-induced immunity in bullous pemphigoid: recent developments
AbstractBullous pemphigoid (BP) is an organ-specific disease. Its pathogenesis has not been clearly studied yet; However, studies in recent years have shown that its pathogenesis is related to T helper cells. The pathogenesis of BP is mainly related to Th2 and Th17-related cytokines. IL-4, IL-5 and...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Annals of Medicine |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2023.2280991 |
| _version_ | 1797302134379642880 |
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| author | Ruiting Huang Lingyu Hu Fuqiong Jiang |
| author_facet | Ruiting Huang Lingyu Hu Fuqiong Jiang |
| author_sort | Ruiting Huang |
| collection | DOAJ |
| description | AbstractBullous pemphigoid (BP) is an organ-specific disease. Its pathogenesis has not been clearly studied yet; However, studies in recent years have shown that its pathogenesis is related to T helper cells. The pathogenesis of BP is mainly related to Th2 and Th17-related cytokines. IL-4, IL-5 and IL-13 cause eosinophil recruitment, promote antibody production, trigger pruritus and promote blister formation and other symptoms. IL-17 and IL-23 promote the production of matrix metalloproteinase-9 (MMP-9) by related cells, which causes dermo-epidermal junction (DEJ) separation to form bullae and blisters, and can persist in BP inflammation. The serum concentrations of IL-17 and IL-23 are related to the prognosis of BP. In this paper, we focus on the role of related cytokines in the pathogenesis of bullous pemphigoid and the relationship between the related cytokine populations secreted by three major T helper cells—helper T lymphocytes 1 (Th1), Th2, and Th17. A better understanding of the biological and immunological functions of cytokines associated with BP patients will provide opportunities for therapeutic targets in BP. |
| first_indexed | 2024-03-07T23:32:24Z |
| format | Article |
| id | doaj.art-3eb3209db10b4d5d82db1e5d1a53af8d |
| institution | Directory Open Access Journal |
| issn | 0785-3890 1365-2060 |
| language | English |
| last_indexed | 2024-03-07T23:32:24Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj.art-3eb3209db10b4d5d82db1e5d1a53af8d2024-02-20T11:58:24ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602023-12-0155210.1080/07853890.2023.2280991Study of cytokine-induced immunity in bullous pemphigoid: recent developmentsRuiting Huang0Lingyu Hu1Fuqiong Jiang2Department of Dermatology, The Second Affiliated Hospital of Kunming Medical University, Kunming, ChinaDepartment of Dermatology, The Second Affiliated Hospital of Kunming Medical University, Kunming, ChinaDepartment of Dermatology, The Second Affiliated Hospital of Kunming Medical University, Kunming, ChinaAbstractBullous pemphigoid (BP) is an organ-specific disease. Its pathogenesis has not been clearly studied yet; However, studies in recent years have shown that its pathogenesis is related to T helper cells. The pathogenesis of BP is mainly related to Th2 and Th17-related cytokines. IL-4, IL-5 and IL-13 cause eosinophil recruitment, promote antibody production, trigger pruritus and promote blister formation and other symptoms. IL-17 and IL-23 promote the production of matrix metalloproteinase-9 (MMP-9) by related cells, which causes dermo-epidermal junction (DEJ) separation to form bullae and blisters, and can persist in BP inflammation. The serum concentrations of IL-17 and IL-23 are related to the prognosis of BP. In this paper, we focus on the role of related cytokines in the pathogenesis of bullous pemphigoid and the relationship between the related cytokine populations secreted by three major T helper cells—helper T lymphocytes 1 (Th1), Th2, and Th17. A better understanding of the biological and immunological functions of cytokines associated with BP patients will provide opportunities for therapeutic targets in BP.https://www.tandfonline.com/doi/10.1080/07853890.2023.2280991Bullous pemphigoidcytokinesinterferon-γinterleukin-4Th1 cellsTh2 cells |
| spellingShingle | Ruiting Huang Lingyu Hu Fuqiong Jiang Study of cytokine-induced immunity in bullous pemphigoid: recent developments Annals of Medicine Bullous pemphigoid cytokines interferon-γ interleukin-4 Th1 cells Th2 cells |
| title | Study of cytokine-induced immunity in bullous pemphigoid: recent developments |
| title_full | Study of cytokine-induced immunity in bullous pemphigoid: recent developments |
| title_fullStr | Study of cytokine-induced immunity in bullous pemphigoid: recent developments |
| title_full_unstemmed | Study of cytokine-induced immunity in bullous pemphigoid: recent developments |
| title_short | Study of cytokine-induced immunity in bullous pemphigoid: recent developments |
| title_sort | study of cytokine induced immunity in bullous pemphigoid recent developments |
| topic | Bullous pemphigoid cytokines interferon-γ interleukin-4 Th1 cells Th2 cells |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2023.2280991 |
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