Dynamic Change of Albumin-Bilirubin Score Is Good Predictive Parameter for Prognosis in Chronic Hepatitis C-hepatocellular Carcinoma Patients Receiving Transarterial Chemoembolization
Background and Aims: The Albumin-Bilirubin (ALBI) grade is a good index for liver function evaluation and is also associated with the outcomes of hepatocellular carcinoma patients receiving TACE. However, the correlation between the dynamic change to the ALBI score and clinical outcome is seldom dis...
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| Format: | Article |
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MDPI AG
2022-03-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/3/665 |
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| author | Po-Ting Lin Wei Teng Wen-Juei Jeng Wei-Ting Chen Yi-Chung Hsieh Chien-Hao Huang Kar-Wai Lui Chen-Fu Hung Ching-Ting Wang Pei-Mei Chai Chen-Chun Lin Chun-Yen Lin Shi-Ming Lin I-Shyan Sheen |
| author_facet | Po-Ting Lin Wei Teng Wen-Juei Jeng Wei-Ting Chen Yi-Chung Hsieh Chien-Hao Huang Kar-Wai Lui Chen-Fu Hung Ching-Ting Wang Pei-Mei Chai Chen-Chun Lin Chun-Yen Lin Shi-Ming Lin I-Shyan Sheen |
| author_sort | Po-Ting Lin |
| collection | DOAJ |
| description | Background and Aims: The Albumin-Bilirubin (ALBI) grade is a good index for liver function evaluation and is also associated with the outcomes of hepatocellular carcinoma patients receiving TACE. However, the correlation between the dynamic change to the ALBI score and clinical outcome is seldom discussed. Therefore, this study aimed to investigate the application of ALBI grade and dynamic change of ALBI grade (delta ALBI grade) after first TACE for prognosis prediction in HCC patients with chronic hepatitis C infection. Method: From January 2005 to December 2015, newly diagnosed naive chronic hepatitis C-hepatocellular carcinoma (CHC-HCC) patients who were treated with TACE as the initial treatment at the Chang Gung Memorial Hospital, Linkou Medical Center, were retrospectively recruited. The pre-treatment host factors, tumor status and noninvasive markers were collected. The Cox regression model was used to identify independent predictors of overall survival and tumor recurrence. Results: Among 613 treatment-naive CHC-HCC patients, 430 patients died after repeated TACE during a median follow-up of 26.9 months. Complete remission after repeated TACE occurred in 46.2% patients, and 208 patients (33.9%) had tumor recurrence, with a median recurrence-free interval of 8.5 months. In Cox regression analysis, ALBI grade II/III (aHR: 1.088, <i>p</i> = 0.035) and increased delta ALBI grade (aHR: 1.456, <i>p</i> = 0.029) were independent predictive factors for tumor recurrence. Furthermore, ALBI grade II/III (aHR: 1.451, <i>p</i> = 0.005) and increased delta ALBI grade during treatment (aHR: 1.436, <i>p</i> = 0.006) were predictive factors for mortality, while achieving complete response after repeated TACE (aHR: 0.373, <i>p</i> < 0.001) and anti-viral therapy (aHR: 0.580, <i>p</i> = 0.002) were protective factors for mortality. Conclusion: Both ALBI and delta ALBI grade are independent parameters to predict survival and tumor recurrence of CHC-HCC patients receiving TACE treatment. |
| first_indexed | 2024-03-09T19:56:49Z |
| format | Article |
| id | doaj.art-3eb35dd792b34d7392db6a0db03e7b39 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T19:56:49Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
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| series | Diagnostics |
| spelling | doaj.art-3eb35dd792b34d7392db6a0db03e7b392023-11-24T00:55:23ZengMDPI AGDiagnostics2075-44182022-03-0112366510.3390/diagnostics12030665Dynamic Change of Albumin-Bilirubin Score Is Good Predictive Parameter for Prognosis in Chronic Hepatitis C-hepatocellular Carcinoma Patients Receiving Transarterial ChemoembolizationPo-Ting Lin0Wei Teng1Wen-Juei Jeng2Wei-Ting Chen3Yi-Chung Hsieh4Chien-Hao Huang5Kar-Wai Lui6Chen-Fu Hung7Ching-Ting Wang8Pei-Mei Chai9Chen-Chun Lin10Chun-Yen Lin11Shi-Ming Lin12I-Shyan Sheen13Department of Gastroenterology and Hepatology, Linkou Branch, Chang Gung Memorial Hospital, Taoyuan 333, TaiwanDepartment of Gastroenterology and Hepatology, Linkou Branch, Chang Gung Memorial Hospital, Taoyuan 333, TaiwanDepartment of Gastroenterology and Hepatology, Linkou Branch, Chang Gung Memorial Hospital, Taoyuan 333, TaiwanDepartment of Gastroenterology and Hepatology, Linkou Branch, Chang Gung Memorial Hospital, Taoyuan 333, TaiwanDepartment of Gastroenterology and Hepatology, Linkou Branch, Chang Gung Memorial Hospital, Taoyuan 333, TaiwanDepartment of Gastroenterology and Hepatology, Linkou Branch, Chang Gung Memorial Hospital, Taoyuan 333, TaiwanCollege of Medicine, Chang Gung University, Taoyuan 333, TaiwanCollege of Medicine, Chang Gung University, Taoyuan 333, TaiwanCollege of Medicine, Chang Gung University, Taoyuan 333, TaiwanCollege of Medicine, Chang Gung University, Taoyuan 333, TaiwanDepartment of Gastroenterology and Hepatology, Linkou Branch, Chang Gung Memorial Hospital, Taoyuan 333, TaiwanDepartment of Gastroenterology and Hepatology, Linkou Branch, Chang Gung Memorial Hospital, Taoyuan 333, TaiwanDepartment of Gastroenterology and Hepatology, Linkou Branch, Chang Gung Memorial Hospital, Taoyuan 333, TaiwanDepartment of Gastroenterology and Hepatology, Linkou Branch, Chang Gung Memorial Hospital, Taoyuan 333, TaiwanBackground and Aims: The Albumin-Bilirubin (ALBI) grade is a good index for liver function evaluation and is also associated with the outcomes of hepatocellular carcinoma patients receiving TACE. However, the correlation between the dynamic change to the ALBI score and clinical outcome is seldom discussed. Therefore, this study aimed to investigate the application of ALBI grade and dynamic change of ALBI grade (delta ALBI grade) after first TACE for prognosis prediction in HCC patients with chronic hepatitis C infection. Method: From January 2005 to December 2015, newly diagnosed naive chronic hepatitis C-hepatocellular carcinoma (CHC-HCC) patients who were treated with TACE as the initial treatment at the Chang Gung Memorial Hospital, Linkou Medical Center, were retrospectively recruited. The pre-treatment host factors, tumor status and noninvasive markers were collected. The Cox regression model was used to identify independent predictors of overall survival and tumor recurrence. Results: Among 613 treatment-naive CHC-HCC patients, 430 patients died after repeated TACE during a median follow-up of 26.9 months. Complete remission after repeated TACE occurred in 46.2% patients, and 208 patients (33.9%) had tumor recurrence, with a median recurrence-free interval of 8.5 months. In Cox regression analysis, ALBI grade II/III (aHR: 1.088, <i>p</i> = 0.035) and increased delta ALBI grade (aHR: 1.456, <i>p</i> = 0.029) were independent predictive factors for tumor recurrence. Furthermore, ALBI grade II/III (aHR: 1.451, <i>p</i> = 0.005) and increased delta ALBI grade during treatment (aHR: 1.436, <i>p</i> = 0.006) were predictive factors for mortality, while achieving complete response after repeated TACE (aHR: 0.373, <i>p</i> < 0.001) and anti-viral therapy (aHR: 0.580, <i>p</i> = 0.002) were protective factors for mortality. Conclusion: Both ALBI and delta ALBI grade are independent parameters to predict survival and tumor recurrence of CHC-HCC patients receiving TACE treatment.https://www.mdpi.com/2075-4418/12/3/665hepatitishepatocellular carcinomaliveralbuminbilirubinalpha-fetoprotein |
| spellingShingle | Po-Ting Lin Wei Teng Wen-Juei Jeng Wei-Ting Chen Yi-Chung Hsieh Chien-Hao Huang Kar-Wai Lui Chen-Fu Hung Ching-Ting Wang Pei-Mei Chai Chen-Chun Lin Chun-Yen Lin Shi-Ming Lin I-Shyan Sheen Dynamic Change of Albumin-Bilirubin Score Is Good Predictive Parameter for Prognosis in Chronic Hepatitis C-hepatocellular Carcinoma Patients Receiving Transarterial Chemoembolization Diagnostics hepatitis hepatocellular carcinoma liver albumin bilirubin alpha-fetoprotein |
| title | Dynamic Change of Albumin-Bilirubin Score Is Good Predictive Parameter for Prognosis in Chronic Hepatitis C-hepatocellular Carcinoma Patients Receiving Transarterial Chemoembolization |
| title_full | Dynamic Change of Albumin-Bilirubin Score Is Good Predictive Parameter for Prognosis in Chronic Hepatitis C-hepatocellular Carcinoma Patients Receiving Transarterial Chemoembolization |
| title_fullStr | Dynamic Change of Albumin-Bilirubin Score Is Good Predictive Parameter for Prognosis in Chronic Hepatitis C-hepatocellular Carcinoma Patients Receiving Transarterial Chemoembolization |
| title_full_unstemmed | Dynamic Change of Albumin-Bilirubin Score Is Good Predictive Parameter for Prognosis in Chronic Hepatitis C-hepatocellular Carcinoma Patients Receiving Transarterial Chemoembolization |
| title_short | Dynamic Change of Albumin-Bilirubin Score Is Good Predictive Parameter for Prognosis in Chronic Hepatitis C-hepatocellular Carcinoma Patients Receiving Transarterial Chemoembolization |
| title_sort | dynamic change of albumin bilirubin score is good predictive parameter for prognosis in chronic hepatitis c hepatocellular carcinoma patients receiving transarterial chemoembolization |
| topic | hepatitis hepatocellular carcinoma liver albumin bilirubin alpha-fetoprotein |
| url | https://www.mdpi.com/2075-4418/12/3/665 |
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