HPV Vaccination after Primary Treatment of HPV-Related Disease across Different Organ Sites: A Multidisciplinary Comprehensive Review and Meta-Analysis
Objective: To assess evidence on the efficacy of adjuvant human papillomavirus (HPV) vaccination in patients treated for HPV-related disease across different susceptible organ sites. Methods: A systematic review was conducted to identify studies addressing the efficacy of adjuvant HPV vaccination on...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/10/2/239 |
| _version_ | 1797476111857221632 |
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| author | Violante Di Donato Giuseppe Caruso Giorgio Bogani Eugenio Nelson Cavallari Gaspare Palaia Giorgia Perniola Massimo Ralli Sara Sorrenti Umberto Romeo Angelina Pernazza Alessandra Pierangeli Ilaria Clementi Andrea Mingoli Andrea Cassoni Federica Tanzi Ilaria Cuccu Nadia Recine Pasquale Mancino Marco de Vincentiis Valentino Valentini Gabriella d’Ettorre Carlo Della Rocca Claudio Maria Mastroianni Guido Antonelli Antonella Polimeni Ludovico Muzii Innocenza Palaia |
| author_facet | Violante Di Donato Giuseppe Caruso Giorgio Bogani Eugenio Nelson Cavallari Gaspare Palaia Giorgia Perniola Massimo Ralli Sara Sorrenti Umberto Romeo Angelina Pernazza Alessandra Pierangeli Ilaria Clementi Andrea Mingoli Andrea Cassoni Federica Tanzi Ilaria Cuccu Nadia Recine Pasquale Mancino Marco de Vincentiis Valentino Valentini Gabriella d’Ettorre Carlo Della Rocca Claudio Maria Mastroianni Guido Antonelli Antonella Polimeni Ludovico Muzii Innocenza Palaia |
| author_sort | Violante Di Donato |
| collection | DOAJ |
| description | Objective: To assess evidence on the efficacy of adjuvant human papillomavirus (HPV) vaccination in patients treated for HPV-related disease across different susceptible organ sites. Methods: A systematic review was conducted to identify studies addressing the efficacy of adjuvant HPV vaccination on reducing the risk of recurrence of HPV-related preinvasive diseases. Results were reported as mean differences or pooled odds ratios (OR) with 95% confidence intervals (95% CI). Results: Sixteen studies were identified for the final analysis. Overall, 21,472 patients with cervical dysplasia were included: 4132 (19.2%) received the peri-operative HPV vaccine, while 17,340 (80.8%) underwent surgical treatment alone. The recurrences of CIN 1+ (OR 0.45, 95% CI 0.27 to 0.73; <i>p</i> = 0.001), CIN 2+ (OR 0.33, 95% CI 0.20 to 0.52; <i>p</i> < 0.0001), and CIN 3 (OR 0.28, 95% CI 0.13 to 0.59; <i>p</i> = 0.0009) were lower in the vaccinated than in unvaccinated group. Similarly, adjuvant vaccination reduced the risk of developing anal intraepithelial neoplasia (<i>p</i> = 0.005) and recurrent respiratory papillomatosis (<i>p</i> = 0.004). No differences in anogenital warts and vulvar intraepithelial neoplasia recurrence rate were observed comparing vaccinated and unvaccinated individuals. Conclusions: Adjuvant HPV vaccination is associated with a reduced risk of CIN recurrence, although there are limited data regarding its role in other HPV-related diseases. Further research is warranted to shed more light on the role of HPV vaccination as adjuvant therapy after primary treatment. |
| first_indexed | 2024-03-09T20:54:19Z |
| format | Article |
| id | doaj.art-3eb42b3ed3874d448bac16f31684f92b |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T20:54:19Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-3eb42b3ed3874d448bac16f31684f92b2023-11-23T22:25:46ZengMDPI AGVaccines2076-393X2022-02-0110223910.3390/vaccines10020239HPV Vaccination after Primary Treatment of HPV-Related Disease across Different Organ Sites: A Multidisciplinary Comprehensive Review and Meta-AnalysisViolante Di Donato0Giuseppe Caruso1Giorgio Bogani2Eugenio Nelson Cavallari3Gaspare Palaia4Giorgia Perniola5Massimo Ralli6Sara Sorrenti7Umberto Romeo8Angelina Pernazza9Alessandra Pierangeli10Ilaria Clementi11Andrea Mingoli12Andrea Cassoni13Federica Tanzi14Ilaria Cuccu15Nadia Recine16Pasquale Mancino17Marco de Vincentiis18Valentino Valentini19Gabriella d’Ettorre20Carlo Della Rocca21Claudio Maria Mastroianni22Guido Antonelli23Antonella Polimeni24Ludovico Muzii25Innocenza Palaia26Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Sense Organs, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Molecular Medicine, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Emergency, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Surgery “Pietro Valdoni”, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Molecular Medicine, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyObjective: To assess evidence on the efficacy of adjuvant human papillomavirus (HPV) vaccination in patients treated for HPV-related disease across different susceptible organ sites. Methods: A systematic review was conducted to identify studies addressing the efficacy of adjuvant HPV vaccination on reducing the risk of recurrence of HPV-related preinvasive diseases. Results were reported as mean differences or pooled odds ratios (OR) with 95% confidence intervals (95% CI). Results: Sixteen studies were identified for the final analysis. Overall, 21,472 patients with cervical dysplasia were included: 4132 (19.2%) received the peri-operative HPV vaccine, while 17,340 (80.8%) underwent surgical treatment alone. The recurrences of CIN 1+ (OR 0.45, 95% CI 0.27 to 0.73; <i>p</i> = 0.001), CIN 2+ (OR 0.33, 95% CI 0.20 to 0.52; <i>p</i> < 0.0001), and CIN 3 (OR 0.28, 95% CI 0.13 to 0.59; <i>p</i> = 0.0009) were lower in the vaccinated than in unvaccinated group. Similarly, adjuvant vaccination reduced the risk of developing anal intraepithelial neoplasia (<i>p</i> = 0.005) and recurrent respiratory papillomatosis (<i>p</i> = 0.004). No differences in anogenital warts and vulvar intraepithelial neoplasia recurrence rate were observed comparing vaccinated and unvaccinated individuals. Conclusions: Adjuvant HPV vaccination is associated with a reduced risk of CIN recurrence, although there are limited data regarding its role in other HPV-related diseases. Further research is warranted to shed more light on the role of HPV vaccination as adjuvant therapy after primary treatment.https://www.mdpi.com/2076-393X/10/2/239human papillomavirusHPVvaccinationcervical cancervulvar canceranogenital warts |
| spellingShingle | Violante Di Donato Giuseppe Caruso Giorgio Bogani Eugenio Nelson Cavallari Gaspare Palaia Giorgia Perniola Massimo Ralli Sara Sorrenti Umberto Romeo Angelina Pernazza Alessandra Pierangeli Ilaria Clementi Andrea Mingoli Andrea Cassoni Federica Tanzi Ilaria Cuccu Nadia Recine Pasquale Mancino Marco de Vincentiis Valentino Valentini Gabriella d’Ettorre Carlo Della Rocca Claudio Maria Mastroianni Guido Antonelli Antonella Polimeni Ludovico Muzii Innocenza Palaia HPV Vaccination after Primary Treatment of HPV-Related Disease across Different Organ Sites: A Multidisciplinary Comprehensive Review and Meta-Analysis Vaccines human papillomavirus HPV vaccination cervical cancer vulvar cancer anogenital warts |
| title | HPV Vaccination after Primary Treatment of HPV-Related Disease across Different Organ Sites: A Multidisciplinary Comprehensive Review and Meta-Analysis |
| title_full | HPV Vaccination after Primary Treatment of HPV-Related Disease across Different Organ Sites: A Multidisciplinary Comprehensive Review and Meta-Analysis |
| title_fullStr | HPV Vaccination after Primary Treatment of HPV-Related Disease across Different Organ Sites: A Multidisciplinary Comprehensive Review and Meta-Analysis |
| title_full_unstemmed | HPV Vaccination after Primary Treatment of HPV-Related Disease across Different Organ Sites: A Multidisciplinary Comprehensive Review and Meta-Analysis |
| title_short | HPV Vaccination after Primary Treatment of HPV-Related Disease across Different Organ Sites: A Multidisciplinary Comprehensive Review and Meta-Analysis |
| title_sort | hpv vaccination after primary treatment of hpv related disease across different organ sites a multidisciplinary comprehensive review and meta analysis |
| topic | human papillomavirus HPV vaccination cervical cancer vulvar cancer anogenital warts |
| url | https://www.mdpi.com/2076-393X/10/2/239 |
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