Pt(II)-PLGA Hybrid in a pH-Responsive Nanoparticle System Targeting Ovarian Cancer

Pt(II)-PLGA Hybrid in a pH-Responsive Nanoparticle System Targeting Ovarian Cancer

Platinum-based agents are the main treatment option in ovarian cancer (OC). Herein, we report a poly(lactic-co-glycolic acid) (PLGA) nanoparticle (NP) encapsulating platinum (II), which is targeted to a cell-spanning protein overexpressed in above 90% of late-stage OC, mucin 1 (MUC1). The NP is coat...

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Bibliographic Details
Main Authors: Marek T. Wlodarczyk, Sylwia A. Dragulska, Ying Chen, Mina Poursharifi, Maxier Acosta Santiago, John A. Martignetti, Aneta J. Mieszawska
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Pharmaceutics
Subjects:
nanoparticles
pH-sensitive
ovarian cancer
platinum therapy
in vivo imaging
Online Access:https://www.mdpi.com/1999-4923/15/2/607

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https://www.mdpi.com/1999-4923/15/2/607

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