Quantitative proteomic analysis of cerebrospinal fluid reveals CD163, A2M and full-length APP as potential diagnostic biomarkers of paediatric bacterial meningitis

Quantitative proteomic analysis of cerebrospinal fluid reveals CD163, A2M and full-length APP as potential diagnostic biomarkers of paediatric bacterial meningitis

Abstract Background Bacterial meningitis (BM) is a life-threatening infectious disease of the central nervous system in infants and children. To date, no diagnostic methods for the early and precise diagnosis of paediatric BM have been developed. Methods A label-free cerebrospinal fluid (CSF) quanti...

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Bibliographic Details
Main Authors: Ting Luo, Sai Yang, Yan Chen, Shulei Liu, Liming Yang, Nanfei Hu, Ye Ma, Jun Qiu, Kewei Wang, Liping Li, Lihong Tan
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Proteome Science
Subjects:
Paediatric bacterial meningitis
Cerebrospinal fluid
Diagnostic biomarkers
Proteomics
Infection of the central nervous system
Online Access:https://doi.org/10.1186/s12953-022-00191-5

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