Second Generation Long-Acting Injectable Antipsychotics in Africa: About a Case
Introduction Schizophrenia affects people worldwide. In Europe, the advantages of second-generation and long-acting injectable antipsychotics (SG-LAIs) are known and used, supported by scientific evidence. However, somewhere there is limited evidence on this topic. Objectives Highlight the improve...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2023-03-01
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| Series: | European Psychiatry |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933823017376/type/journal_article |
| _version_ | 1797617405980049408 |
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| author | J. Galvañ F. R. Nguepy-Keubo |
| author_facet | J. Galvañ F. R. Nguepy-Keubo |
| author_sort | J. Galvañ |
| collection | DOAJ |
| description |
Introduction
Schizophrenia affects people worldwide. In Europe, the advantages of second-generation and long-acting injectable antipsychotics (SG-LAIs) are known and used, supported by scientific evidence. However, somewhere there is limited evidence on this topic.
Objectives
Highlight the improvements in antipsychotic treatment and raise awareness of the scar between Europe and Africa, showing the results of the evidence with a case of cooperation with Cameroon.
Methods
About a case of a 42-year-old Cameroonian woman with 25 years of schizophrenia, treated with first-generation antipsychotic polypharmacy (APP) oral and depot, with several psychotic relapses, disorganized behaviors, motor and cognitive impairment and isolation (telemedicine consultation received through a NGO platform).
A search on PubMed was performed, selecting two systematic reviews including “antipsychotic” AND “Africa”, one systematic review for SGAs and four reviews for LAIs.
Results
Seven articles were reviewed, finding that APP use is highly prevalent in Africa with a lack of research on this, SGAs show an improved safety and tolerability profile and LAIs are among the most effective treatments in psychiatry improving adherence and overall patient outcomes.
In our case, we recommend progressively adjusting treatment to SG-LAI monotherapy, visiting the patient six months later in Cameroon, observing sustained stability of positive symptoms with an improvement of negative symptoms and good adherence and tolerability to treatment without extrapyramidal effects.
Conclusions
Our case is an example of the evidence that supports the improvement that SG-LAIs represent in psychiatric treatment and how international cooperation can help bridge the gap between Africa and Europe. Nevertheless, more research is needed to build bridges.
Disclosure of Interest
None Declared |
| first_indexed | 2024-03-11T07:55:31Z |
| format | Article |
| id | doaj.art-3eb5fecaa63743a3a82bae324d2578e7 |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:55:31Z |
| publishDate | 2023-03-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-3eb5fecaa63743a3a82bae324d2578e72023-11-17T05:05:52ZengCambridge University PressEuropean Psychiatry0924-93381778-35852023-03-0166S820S82010.1192/j.eurpsy.2023.1737Second Generation Long-Acting Injectable Antipsychotics in Africa: About a CaseJ. Galvañ0F. R. Nguepy-Keubo1Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health Hospital General Universitario Gregorio Marañón, Madrid, SpainHôpital Saint Vincent de Paul, Dschang, Cameroon Introduction Schizophrenia affects people worldwide. In Europe, the advantages of second-generation and long-acting injectable antipsychotics (SG-LAIs) are known and used, supported by scientific evidence. However, somewhere there is limited evidence on this topic. Objectives Highlight the improvements in antipsychotic treatment and raise awareness of the scar between Europe and Africa, showing the results of the evidence with a case of cooperation with Cameroon. Methods About a case of a 42-year-old Cameroonian woman with 25 years of schizophrenia, treated with first-generation antipsychotic polypharmacy (APP) oral and depot, with several psychotic relapses, disorganized behaviors, motor and cognitive impairment and isolation (telemedicine consultation received through a NGO platform). A search on PubMed was performed, selecting two systematic reviews including “antipsychotic” AND “Africa”, one systematic review for SGAs and four reviews for LAIs. Results Seven articles were reviewed, finding that APP use is highly prevalent in Africa with a lack of research on this, SGAs show an improved safety and tolerability profile and LAIs are among the most effective treatments in psychiatry improving adherence and overall patient outcomes. In our case, we recommend progressively adjusting treatment to SG-LAI monotherapy, visiting the patient six months later in Cameroon, observing sustained stability of positive symptoms with an improvement of negative symptoms and good adherence and tolerability to treatment without extrapyramidal effects. Conclusions Our case is an example of the evidence that supports the improvement that SG-LAIs represent in psychiatric treatment and how international cooperation can help bridge the gap between Africa and Europe. Nevertheless, more research is needed to build bridges. Disclosure of Interest None Declaredhttps://www.cambridge.org/core/product/identifier/S0924933823017376/type/journal_article |
| spellingShingle | J. Galvañ F. R. Nguepy-Keubo Second Generation Long-Acting Injectable Antipsychotics in Africa: About a Case European Psychiatry |
| title | Second Generation Long-Acting Injectable Antipsychotics in Africa: About a Case |
| title_full | Second Generation Long-Acting Injectable Antipsychotics in Africa: About a Case |
| title_fullStr | Second Generation Long-Acting Injectable Antipsychotics in Africa: About a Case |
| title_full_unstemmed | Second Generation Long-Acting Injectable Antipsychotics in Africa: About a Case |
| title_short | Second Generation Long-Acting Injectable Antipsychotics in Africa: About a Case |
| title_sort | second generation long acting injectable antipsychotics in africa about a case |
| url | https://www.cambridge.org/core/product/identifier/S0924933823017376/type/journal_article |
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