Potential role of APOE ɛ4 allele as a modifier for the association of BDNF Val66Met polymorphisms and cognitive impairment in community-dwelling older adults

Potential role of APOE ɛ4 allele as a modifier for the association of BDNF Val66Met polymorphisms and cognitive impairment in community-dwelling older adults

ObjectiveTo determine whether the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with cognitive impairment (CI) in community-dwelling Chinese older adults, and to investigate whether this relationship is modified by the Apolipoprotein E (APOE) ɛ4 allele.MethodsThe study...

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Bibliographic Details
Main Authors: Shaozhen Ji, Jia Kang, Chao Han, Xitong Xu, Meijie Chen, Jie Chen, Jagadish K Chhetri, Jing Pan, Piu Chan
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Aging Neuroscience
Subjects:
APOE ε4
BDNF Val66Met
cognitive impairment
older adults
modify
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2024.1330193/full

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