Analysing functional implications of differences in left ventricular morphology using statistical shape modelling
Abstract Functional implications of left ventricular (LV) morphological characterization in congenital heart disease are not widely explored. This study qualitatively and quantitatively assessed LV shape associations with a) LV function and b) thoracic aortic morphology in patients with aortic coarc...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-15888-y |
| _version_ | 1811230544967499776 |
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| author | Froso Sophocleous Lucy Standen Gemina Doolub Reem Laymouna Chiara Bucciarelli-Ducci Massimo Caputo Nathan Manghat Mark Hamilton Stephanie Curtis Giovanni Biglino |
| author_facet | Froso Sophocleous Lucy Standen Gemina Doolub Reem Laymouna Chiara Bucciarelli-Ducci Massimo Caputo Nathan Manghat Mark Hamilton Stephanie Curtis Giovanni Biglino |
| author_sort | Froso Sophocleous |
| collection | DOAJ |
| description | Abstract Functional implications of left ventricular (LV) morphological characterization in congenital heart disease are not widely explored. This study qualitatively and quantitatively assessed LV shape associations with a) LV function and b) thoracic aortic morphology in patients with aortic coarctation (CoA) with/without bicuspid aortic valve (BAV), and healthy controls. A statistical shape modelling framework was employed to analyse three-dimensional (3D) LV shapes from cardiac magnetic resonance (CMR) data in isolated CoA (n = 25), CoA + BAV (n = 30), isolated BAV (n = 30), and healthy controls (n = 25). Average 3D templates and deformations were computed. Correlations between shape data and CMR-derived morphometric parameters (i.e., sphericity, conicity) or global and apical strain values were assessed to elucidate possible functional implications. The relationship between LV shape features and arch architecture was also explored. The LV template was shorter and more spherical in CoA patients. Sphericity was overall associated with global and apical radial (p = 0.001, R2 = 0.09; p < 0.0001, R2 = 0.17) and circumferential strain (p = 0.001, R2 = 0.10; p = 0.04, R2 = 0.04), irrespective of the presence of aortic stenosis and/or regurgitation and controlling for age and hypertension status. LV strain was not associated with arch architecture. Differences in LV morphology were observed between CoA and BAV patients. Increasing LV sphericity was associated with reduced strain, independent of aortic arch architecture and functional aortic valve disease. |
| first_indexed | 2024-04-12T10:30:10Z |
| format | Article |
| id | doaj.art-3eb79555d4084860a1ce686404c40322 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T10:30:10Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-3eb79555d4084860a1ce686404c403222022-12-22T03:36:52ZengNature PortfolioScientific Reports2045-23222022-11-0112111210.1038/s41598-022-15888-yAnalysing functional implications of differences in left ventricular morphology using statistical shape modellingFroso Sophocleous0Lucy Standen1Gemina Doolub2Reem Laymouna3Chiara Bucciarelli-Ducci4Massimo Caputo5Nathan Manghat6Mark Hamilton7Stephanie Curtis8Giovanni Biglino9Bristol Medical School, Faculty of Life Sciences, Bristol Heart Institute, Bristol Royal Infirmary, University of BristolBristol Medical School, Faculty of Life Sciences, Bristol Heart Institute, Bristol Royal Infirmary, University of BristolBristol Heart Institute, University Hospitals Bristol and Weston NHS Foundation TrustBristol Heart Institute, University Hospitals Bristol and Weston NHS Foundation TrustBristol Medical School, Faculty of Life Sciences, Bristol Heart Institute, Bristol Royal Infirmary, University of BristolBristol Medical School, Faculty of Life Sciences, Bristol Heart Institute, Bristol Royal Infirmary, University of BristolBristol Heart Institute, University Hospitals Bristol and Weston NHS Foundation TrustBristol Heart Institute, University Hospitals Bristol and Weston NHS Foundation TrustBristol Heart Institute, University Hospitals Bristol and Weston NHS Foundation TrustBristol Medical School, Faculty of Life Sciences, Bristol Heart Institute, Bristol Royal Infirmary, University of BristolAbstract Functional implications of left ventricular (LV) morphological characterization in congenital heart disease are not widely explored. This study qualitatively and quantitatively assessed LV shape associations with a) LV function and b) thoracic aortic morphology in patients with aortic coarctation (CoA) with/without bicuspid aortic valve (BAV), and healthy controls. A statistical shape modelling framework was employed to analyse three-dimensional (3D) LV shapes from cardiac magnetic resonance (CMR) data in isolated CoA (n = 25), CoA + BAV (n = 30), isolated BAV (n = 30), and healthy controls (n = 25). Average 3D templates and deformations were computed. Correlations between shape data and CMR-derived morphometric parameters (i.e., sphericity, conicity) or global and apical strain values were assessed to elucidate possible functional implications. The relationship between LV shape features and arch architecture was also explored. The LV template was shorter and more spherical in CoA patients. Sphericity was overall associated with global and apical radial (p = 0.001, R2 = 0.09; p < 0.0001, R2 = 0.17) and circumferential strain (p = 0.001, R2 = 0.10; p = 0.04, R2 = 0.04), irrespective of the presence of aortic stenosis and/or regurgitation and controlling for age and hypertension status. LV strain was not associated with arch architecture. Differences in LV morphology were observed between CoA and BAV patients. Increasing LV sphericity was associated with reduced strain, independent of aortic arch architecture and functional aortic valve disease.https://doi.org/10.1038/s41598-022-15888-y |
| spellingShingle | Froso Sophocleous Lucy Standen Gemina Doolub Reem Laymouna Chiara Bucciarelli-Ducci Massimo Caputo Nathan Manghat Mark Hamilton Stephanie Curtis Giovanni Biglino Analysing functional implications of differences in left ventricular morphology using statistical shape modelling Scientific Reports |
| title | Analysing functional implications of differences in left ventricular morphology using statistical shape modelling |
| title_full | Analysing functional implications of differences in left ventricular morphology using statistical shape modelling |
| title_fullStr | Analysing functional implications of differences in left ventricular morphology using statistical shape modelling |
| title_full_unstemmed | Analysing functional implications of differences in left ventricular morphology using statistical shape modelling |
| title_short | Analysing functional implications of differences in left ventricular morphology using statistical shape modelling |
| title_sort | analysing functional implications of differences in left ventricular morphology using statistical shape modelling |
| url | https://doi.org/10.1038/s41598-022-15888-y |
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