Chiral nanomaterials for tumor therapy: autophagy, apoptosis, and photothermal ablation
Abstract Chirality is a fundamental characteristic of natural molecules and a crucial factor in the biochemical reactions of living cells and organisms. Recently, researchers have successfully introduced chiral molecules to the surfaces of nanomaterials, creating chiral nanomaterials that exhibit an...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-07-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-021-00965-7 |
| _version_ | 1811306122398662656 |
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| author | Zaihui Peng Long Yuan Juncheng XuHong Hao Tian Yi Zhang Jun Deng Xiaowei Qi |
| author_facet | Zaihui Peng Long Yuan Juncheng XuHong Hao Tian Yi Zhang Jun Deng Xiaowei Qi |
| author_sort | Zaihui Peng |
| collection | DOAJ |
| description | Abstract Chirality is a fundamental characteristic of natural molecules and a crucial factor in the biochemical reactions of living cells and organisms. Recently, researchers have successfully introduced chiral molecules to the surfaces of nanomaterials, creating chiral nanomaterials that exhibit an upscaling of chiral behavior from the molecular scale to the nanoscale. These chiral nanomaterials can selectively induce autophagy, apoptosis, and photothermal ablation in tumor cells based on their chirality, making them promising for application in anti-tumor therapy. However, these interesting and important phenomena have hitherto received little attention. Accordingly, we herein present a review of recent research progress in the field of chiral nanomaterials for tumor therapy along with brief looks at the mechanistic details of their actions. Finally, the current challenges and future perspectives of chiral nanomaterials in terms of maximizing their potential in tumor therapy are discussed. Thus, this review provides a helpful introduction to the design of chiral nanomaterials and will hopefully highlight the importance of chirality in tumor therapy. |
| first_indexed | 2024-04-13T08:38:45Z |
| format | Article |
| id | doaj.art-3eb95243683648c0ae464e229a1100bb |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-13T08:38:45Z |
| publishDate | 2021-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-3eb95243683648c0ae464e229a1100bb2022-12-22T02:54:00ZengBMCJournal of Nanobiotechnology1477-31552021-07-0119111310.1186/s12951-021-00965-7Chiral nanomaterials for tumor therapy: autophagy, apoptosis, and photothermal ablationZaihui Peng0Long Yuan1Juncheng XuHong2Hao Tian3Yi Zhang4Jun Deng5Xiaowei Qi6Department of Breast Surgery, Southwest Hospital, Army Medical UniversityDepartment of Breast Surgery, Southwest Hospital, Army Medical UniversityDepartment of Breast Surgery, Southwest Hospital, Army Medical UniversityDepartment of Breast Surgery, Southwest Hospital, Army Medical UniversityDepartment of Breast Surgery, Southwest Hospital, Army Medical UniversityInstitute of Burn Research, Southwest Hospital, State Key Lab of Trauma, Burn and Combined Injury, Army Medical UniversityDepartment of Breast Surgery, Southwest Hospital, Army Medical UniversityAbstract Chirality is a fundamental characteristic of natural molecules and a crucial factor in the biochemical reactions of living cells and organisms. Recently, researchers have successfully introduced chiral molecules to the surfaces of nanomaterials, creating chiral nanomaterials that exhibit an upscaling of chiral behavior from the molecular scale to the nanoscale. These chiral nanomaterials can selectively induce autophagy, apoptosis, and photothermal ablation in tumor cells based on their chirality, making them promising for application in anti-tumor therapy. However, these interesting and important phenomena have hitherto received little attention. Accordingly, we herein present a review of recent research progress in the field of chiral nanomaterials for tumor therapy along with brief looks at the mechanistic details of their actions. Finally, the current challenges and future perspectives of chiral nanomaterials in terms of maximizing their potential in tumor therapy are discussed. Thus, this review provides a helpful introduction to the design of chiral nanomaterials and will hopefully highlight the importance of chirality in tumor therapy.https://doi.org/10.1186/s12951-021-00965-7ChiralityNanomedicineBiomaterialsTumor therapy |
| spellingShingle | Zaihui Peng Long Yuan Juncheng XuHong Hao Tian Yi Zhang Jun Deng Xiaowei Qi Chiral nanomaterials for tumor therapy: autophagy, apoptosis, and photothermal ablation Journal of Nanobiotechnology Chirality Nanomedicine Biomaterials Tumor therapy |
| title | Chiral nanomaterials for tumor therapy: autophagy, apoptosis, and photothermal ablation |
| title_full | Chiral nanomaterials for tumor therapy: autophagy, apoptosis, and photothermal ablation |
| title_fullStr | Chiral nanomaterials for tumor therapy: autophagy, apoptosis, and photothermal ablation |
| title_full_unstemmed | Chiral nanomaterials for tumor therapy: autophagy, apoptosis, and photothermal ablation |
| title_short | Chiral nanomaterials for tumor therapy: autophagy, apoptosis, and photothermal ablation |
| title_sort | chiral nanomaterials for tumor therapy autophagy apoptosis and photothermal ablation |
| topic | Chirality Nanomedicine Biomaterials Tumor therapy |
| url | https://doi.org/10.1186/s12951-021-00965-7 |
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