Advances in the use of local anesthetic extended-release systems in pain management
AbstractPain management remains among the most common and largely unmet clinical problems today. Local anesthetics play an indispensable role in pain management. The main limitation of traditional local anesthetics is the limited duration of a single injection. To address this problem, catheters are...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
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| Series: | Drug Delivery |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/10717544.2023.2296349 |
| _version_ | 1797382697236037632 |
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| author | Yulu Chen Jingmei Xu Ping Li Liyang Shi Sha Zhang Qulian Guo Yong Yang |
| author_facet | Yulu Chen Jingmei Xu Ping Li Liyang Shi Sha Zhang Qulian Guo Yong Yang |
| author_sort | Yulu Chen |
| collection | DOAJ |
| description | AbstractPain management remains among the most common and largely unmet clinical problems today. Local anesthetics play an indispensable role in pain management. The main limitation of traditional local anesthetics is the limited duration of a single injection. To address this problem, catheters are often placed or combined with other drugs in clinical practice to increase the time that local anesthetics act. However, this method does not meet the needs of clinical analgesics. Therefore, many researchers have worked to develop local anesthetic extended-release types that can be administered in a single dose. In recent years, drug extended-release systems have emerged dramatically due to their long duration and efficacy, providing more possibilities for the application of local anesthetics. This paper summarizes the types of local anesthetic drug delivery systems and their clinical applications, discusses them in the context of relevant studies on local anesthetics, and provides a summary and outlook on the development of local anesthetic extended-release agents. |
| first_indexed | 2024-03-08T21:10:14Z |
| format | Article |
| id | doaj.art-3eba241edb18498abf738afd85adb00f |
| institution | Directory Open Access Journal |
| issn | 1071-7544 1521-0464 |
| language | English |
| last_indexed | 2024-03-08T21:10:14Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Drug Delivery |
| spelling | doaj.art-3eba241edb18498abf738afd85adb00f2023-12-22T07:44:40ZengTaylor & Francis GroupDrug Delivery1071-75441521-04642024-12-0131110.1080/10717544.2023.2296349Advances in the use of local anesthetic extended-release systems in pain managementYulu Chen0Jingmei Xu1Ping Li2Liyang Shi3Sha Zhang4Qulian Guo5Yong Yang6Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Anesthesiology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaCollege of Biology, Hunan University, Changsha, ChinaDepartment of Anesthesiology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Anesthesiology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Anesthesiology, Xiangya Hospital, Central South University, Changsha, ChinaAbstractPain management remains among the most common and largely unmet clinical problems today. Local anesthetics play an indispensable role in pain management. The main limitation of traditional local anesthetics is the limited duration of a single injection. To address this problem, catheters are often placed or combined with other drugs in clinical practice to increase the time that local anesthetics act. However, this method does not meet the needs of clinical analgesics. Therefore, many researchers have worked to develop local anesthetic extended-release types that can be administered in a single dose. In recent years, drug extended-release systems have emerged dramatically due to their long duration and efficacy, providing more possibilities for the application of local anesthetics. This paper summarizes the types of local anesthetic drug delivery systems and their clinical applications, discusses them in the context of relevant studies on local anesthetics, and provides a summary and outlook on the development of local anesthetic extended-release agents.https://www.tandfonline.com/doi/10.1080/10717544.2023.2296349Pain managementlocal anestheticsextended-release systemdrug delivery system |
| spellingShingle | Yulu Chen Jingmei Xu Ping Li Liyang Shi Sha Zhang Qulian Guo Yong Yang Advances in the use of local anesthetic extended-release systems in pain management Drug Delivery Pain management local anesthetics extended-release system drug delivery system |
| title | Advances in the use of local anesthetic extended-release systems in pain management |
| title_full | Advances in the use of local anesthetic extended-release systems in pain management |
| title_fullStr | Advances in the use of local anesthetic extended-release systems in pain management |
| title_full_unstemmed | Advances in the use of local anesthetic extended-release systems in pain management |
| title_short | Advances in the use of local anesthetic extended-release systems in pain management |
| title_sort | advances in the use of local anesthetic extended release systems in pain management |
| topic | Pain management local anesthetics extended-release system drug delivery system |
| url | https://www.tandfonline.com/doi/10.1080/10717544.2023.2296349 |
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