Effects of entorhinal cortex lesions on memory in different tasks
Lesions of the entorhinal cortex produce retrograde memory impairment in both animals and humans. Here we report the effects of bilateral entorhinal cortex lesions caused by the stereotaxic infusion of N-methyl-D-aspartate (NMDA) in rats at two different moments, before or after the training session...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
1997-06-01
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| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000600011 |
| _version_ | 1811208597513699328 |
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| author | G.P. Gutierrez-Figueroa C. Dalmaz I. Izquierdo |
| author_facet | G.P. Gutierrez-Figueroa C. Dalmaz I. Izquierdo |
| author_sort | G.P. Gutierrez-Figueroa |
| collection | DOAJ |
| description | Lesions of the entorhinal cortex produce retrograde memory impairment in both animals and humans. Here we report the effects of bilateral entorhinal cortex lesions caused by the stereotaxic infusion of N-methyl-D-aspartate (NMDA) in rats at two different moments, before or after the training session, on memory of different tasks: two-way shuttle avoidance, inhibitory avoidance and habituation to an open field. Pre- or post-training entorhinal cortex lesions caused an impairment of performance in the shuttle avoidance task, which agrees with the previously described role of this area in the processing of memories acquired in successive sessions. In the inhibitory avoidance task, only the post-training lesions had an effect (amnesia). No effect was observed on the open field task. The findings suggest that the role of the entorhinal cortex in memory processing is task-dependent, perhaps related to the complexity of each task |
| first_indexed | 2024-04-12T04:24:23Z |
| format | Article |
| id | doaj.art-3eba910471c644ab9deb5b8a6fa23a23 |
| institution | Directory Open Access Journal |
| issn | 0100-879X 1414-431X |
| language | English |
| last_indexed | 2024-04-12T04:24:23Z |
| publishDate | 1997-06-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-3eba910471c644ab9deb5b8a6fa23a232022-12-22T03:48:08ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X1997-06-0130676910.1590/S0100-879X1997000600011Effects of entorhinal cortex lesions on memory in different tasksG.P. Gutierrez-FigueroaC. DalmazI. IzquierdoLesions of the entorhinal cortex produce retrograde memory impairment in both animals and humans. Here we report the effects of bilateral entorhinal cortex lesions caused by the stereotaxic infusion of N-methyl-D-aspartate (NMDA) in rats at two different moments, before or after the training session, on memory of different tasks: two-way shuttle avoidance, inhibitory avoidance and habituation to an open field. Pre- or post-training entorhinal cortex lesions caused an impairment of performance in the shuttle avoidance task, which agrees with the previously described role of this area in the processing of memories acquired in successive sessions. In the inhibitory avoidance task, only the post-training lesions had an effect (amnesia). No effect was observed on the open field task. The findings suggest that the role of the entorhinal cortex in memory processing is task-dependent, perhaps related to the complexity of each taskhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000600011entorhinal cortexmemoryNMDA lesions |
| spellingShingle | G.P. Gutierrez-Figueroa C. Dalmaz I. Izquierdo Effects of entorhinal cortex lesions on memory in different tasks Brazilian Journal of Medical and Biological Research entorhinal cortex memory NMDA lesions |
| title | Effects of entorhinal cortex lesions on memory in different tasks |
| title_full | Effects of entorhinal cortex lesions on memory in different tasks |
| title_fullStr | Effects of entorhinal cortex lesions on memory in different tasks |
| title_full_unstemmed | Effects of entorhinal cortex lesions on memory in different tasks |
| title_short | Effects of entorhinal cortex lesions on memory in different tasks |
| title_sort | effects of entorhinal cortex lesions on memory in different tasks |
| topic | entorhinal cortex memory NMDA lesions |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000600011 |
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