Homeostatic Disorders in Acute Poisoning by Psychotropic Agents
Objective: to determine the impact of the degree of oxidative stress on homeostatic parameters in critically ill patients with acute poisoning by psychotropic agents (PTA).Materials and methods. The components of lipid peroxidation (LPO) and the antioxidative system (AOS), blood rheological and immu...
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| Format: | Article |
| Language: | English |
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2007-02-01
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| Series: | Общая реаниматология |
| Subjects: | |
| Online Access: | https://www.reanimatology.com/rmt/article/view/1082 |
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| author | M. V. Belova K. K. Ilyashenko T. V. Yermokhina Ye. A. Luzhnikov B. V. Davydov S. B. Matveyev |
| author_facet | M. V. Belova K. K. Ilyashenko T. V. Yermokhina Ye. A. Luzhnikov B. V. Davydov S. B. Matveyev |
| author_sort | M. V. Belova |
| collection | DOAJ |
| description | Objective: to determine the impact of the degree of oxidative stress on homeostatic parameters in critically ill patients with acute poisoning by psychotropic agents (PTA).Materials and methods. The components of lipid peroxidation (LPO) and the antioxidative system (AOS), blood rheological and immunological parameters, and the markers of endogenous intoxication were studied in 43 patients with severe acute PTA intoxication before and during intensive detoxification therapy.Results. The first hours of poisoning were marked by LPO-AOS imbalance with a significant preponderance of peroxidation processes, by impaired blood viscous properties, the manifestations of secondary immunodeficiency and endogenous intoxication. There were changes in the study parameters during detoxification therapy and at the early somatogenic stage of the disease.Conclusion. In patients with acute poisoning-induced critical conditions, the degree of oxidative stress affects the time course of homeostatic changes and determines the severity of endotoxicosis at all stages of the disease. |
| first_indexed | 2024-04-10T01:30:18Z |
| format | Article |
| id | doaj.art-3ebab00269ce490c8ad8e31f1ce545f4 |
| institution | Directory Open Access Journal |
| issn | 1813-9779 2411-7110 |
| language | English |
| last_indexed | 2024-04-10T01:30:18Z |
| publishDate | 2007-02-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj.art-3ebab00269ce490c8ad8e31f1ce545f42023-03-13T09:32:47ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102007-02-0131283110.15360/1813-9779-2007-1-28-311082Homeostatic Disorders in Acute Poisoning by Psychotropic AgentsM. V. Belova0K. K. Ilyashenko1T. V. Yermokhina2Ye. A. Luzhnikov3B. V. Davydov4S. B. Matveyev5НИИ скорой помощи им. Н. В. Склифосовского, МоскваНИИ скорой помощи им. Н. В. Склифосовского, МоскваНИИ скорой помощи им. Н. В. Склифосовского, МоскваНИИ скорой помощи им. Н. В. Склифосовского, МоскваНИИ скорой помощи им. Н. В. Склифосовского, МоскваНИИ скорой помощи им. Н. В. Склифосовского, МоскваObjective: to determine the impact of the degree of oxidative stress on homeostatic parameters in critically ill patients with acute poisoning by psychotropic agents (PTA).Materials and methods. The components of lipid peroxidation (LPO) and the antioxidative system (AOS), blood rheological and immunological parameters, and the markers of endogenous intoxication were studied in 43 patients with severe acute PTA intoxication before and during intensive detoxification therapy.Results. The first hours of poisoning were marked by LPO-AOS imbalance with a significant preponderance of peroxidation processes, by impaired blood viscous properties, the manifestations of secondary immunodeficiency and endogenous intoxication. There were changes in the study parameters during detoxification therapy and at the early somatogenic stage of the disease.Conclusion. In patients with acute poisoning-induced critical conditions, the degree of oxidative stress affects the time course of homeostatic changes and determines the severity of endotoxicosis at all stages of the disease.https://www.reanimatology.com/rmt/article/view/1082окислительный стрессострые отравления психотропными препаратамигомеостаз |
| spellingShingle | M. V. Belova K. K. Ilyashenko T. V. Yermokhina Ye. A. Luzhnikov B. V. Davydov S. B. Matveyev Homeostatic Disorders in Acute Poisoning by Psychotropic Agents Общая реаниматология окислительный стресс острые отравления психотропными препаратами гомеостаз |
| title | Homeostatic Disorders in Acute Poisoning by Psychotropic Agents |
| title_full | Homeostatic Disorders in Acute Poisoning by Psychotropic Agents |
| title_fullStr | Homeostatic Disorders in Acute Poisoning by Psychotropic Agents |
| title_full_unstemmed | Homeostatic Disorders in Acute Poisoning by Psychotropic Agents |
| title_short | Homeostatic Disorders in Acute Poisoning by Psychotropic Agents |
| title_sort | homeostatic disorders in acute poisoning by psychotropic agents |
| topic | окислительный стресс острые отравления психотропными препаратами гомеостаз |
| url | https://www.reanimatology.com/rmt/article/view/1082 |
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