Light-Induced Activation of a Specific Type-5 Metabotropic Glutamate Receptor Antagonist in the Ventrobasal Thalamus Causes Analgesia in a Mouse Model of Breakthrough Cancer Pain

Light-Induced Activation of a Specific Type-5 Metabotropic Glutamate Receptor Antagonist in the Ventrobasal Thalamus Causes Analgesia in a Mouse Model of Breakthrough Cancer Pain

Breakthrough cancer pain (BTcP) refers to a sudden and transient exacerbation of pain, which develops in patients treated with opioid analgesics. Fast-onset analgesia is required for the treatment of BTcP. Light-activated drugs offer a novel potential strategy for the rapid control of pain without t...

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Bibliographic Details
Main Authors: Serena Notartomaso, Nico Antenucci, Francesca Liberatore, Giada Mascio, Stefano Vito Boccadamo Pompili, Joan Font, Mariarosaria Scioli, Livio Luongo, Antonietta Arcella, Roberto Gradini, Amadeu Llebaria, Ferdinando Nicoletti
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:International Journal of Molecular Sciences
Subjects:
breakthrough cancer pain (BTcP)
optopharmacology
metabotropic glutamate receptor 5
analgesia
thalamus
Online Access:https://www.mdpi.com/1422-0067/23/14/8018

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