Neuroprotection of phytic acid in Parkinson’s and Alzheimer’s disease
Parkinson’s disease (PD) and Alzheimer’s disease (AD) are two of the most common neurodegenerative disorders, characterized by the progressive loss of neurons. These two diseases share common molecular mechanisms, including brain iron accumulation, oxidative stress, protein aggregation, and neuroinf...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464623004565 |
| _version_ | 1797632687701229568 |
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| author | Yujie Chen Wuke Yuan Qi Xu Manju B. Reddy |
| author_facet | Yujie Chen Wuke Yuan Qi Xu Manju B. Reddy |
| author_sort | Yujie Chen |
| collection | DOAJ |
| description | Parkinson’s disease (PD) and Alzheimer’s disease (AD) are two of the most common neurodegenerative disorders, characterized by the progressive loss of neurons. These two diseases share common molecular mechanisms, including brain iron accumulation, oxidative stress, protein aggregation, and neuroinflammation. There is no effective therapy to halt the progression of PD or AD. However, accumulating evidence suggests that the consumption of phytochemicals may delay the onset or slow down the progression of neurodegeneration. Phytic acid, is a dihydrogenphosphate ester of inositol. It is stored as phosphorus in plant seeds like cereals, legumes, and nuts. Traditionally, IP6 has been considered an anti-nutritional factor due to its mineral chelating properties, which can reduce mineral absorption. Recent research also indicates its potential benefits for neurodegenerative disorders. In this review, we will summarize the sources and bioavailability of IP6 and its potential neuroprotective roles in preventing or slowing down the progression of PD and AD. |
| first_indexed | 2024-03-11T11:41:20Z |
| format | Article |
| id | doaj.art-3ebb89d9b04f42299bc98628b09d846b |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-11T11:41:20Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-3ebb89d9b04f42299bc98628b09d846b2023-11-10T04:16:13ZengElsevierJournal of Functional Foods1756-46462023-11-01110105856Neuroprotection of phytic acid in Parkinson’s and Alzheimer’s diseaseYujie Chen0Wuke Yuan1Qi Xu2Manju B. Reddy3School of Public Health, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaSchool of Public Health, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaSchool of Public Health, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Corresponding authors.Iowa State University, Ames, IA 50010, USA; Corresponding authors.Parkinson’s disease (PD) and Alzheimer’s disease (AD) are two of the most common neurodegenerative disorders, characterized by the progressive loss of neurons. These two diseases share common molecular mechanisms, including brain iron accumulation, oxidative stress, protein aggregation, and neuroinflammation. There is no effective therapy to halt the progression of PD or AD. However, accumulating evidence suggests that the consumption of phytochemicals may delay the onset or slow down the progression of neurodegeneration. Phytic acid, is a dihydrogenphosphate ester of inositol. It is stored as phosphorus in plant seeds like cereals, legumes, and nuts. Traditionally, IP6 has been considered an anti-nutritional factor due to its mineral chelating properties, which can reduce mineral absorption. Recent research also indicates its potential benefits for neurodegenerative disorders. In this review, we will summarize the sources and bioavailability of IP6 and its potential neuroprotective roles in preventing or slowing down the progression of PD and AD.http://www.sciencedirect.com/science/article/pii/S1756464623004565Phytic acidParkinson’s diseaseAlzheimer’s diseaseNeuroprotection |
| spellingShingle | Yujie Chen Wuke Yuan Qi Xu Manju B. Reddy Neuroprotection of phytic acid in Parkinson’s and Alzheimer’s disease Journal of Functional Foods Phytic acid Parkinson’s disease Alzheimer’s disease Neuroprotection |
| title | Neuroprotection of phytic acid in Parkinson’s and Alzheimer’s disease |
| title_full | Neuroprotection of phytic acid in Parkinson’s and Alzheimer’s disease |
| title_fullStr | Neuroprotection of phytic acid in Parkinson’s and Alzheimer’s disease |
| title_full_unstemmed | Neuroprotection of phytic acid in Parkinson’s and Alzheimer’s disease |
| title_short | Neuroprotection of phytic acid in Parkinson’s and Alzheimer’s disease |
| title_sort | neuroprotection of phytic acid in parkinson s and alzheimer s disease |
| topic | Phytic acid Parkinson’s disease Alzheimer’s disease Neuroprotection |
| url | http://www.sciencedirect.com/science/article/pii/S1756464623004565 |
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