Effect of Dispersion Medium on Pharmacokinetic Profile of Rotigotine Crystalline Suspension following Subcutaneous Injection

Effect of Dispersion Medium on Pharmacokinetic Profile of Rotigotine Crystalline Suspension following Subcutaneous Injection

Rotigotine (RTG) is prescribed as a once-daily transdermal patch for managing early Parkinson’s disease (PD), which presents issues such as skin irritation and poor patient adherence. Therefore, the aims of the present study were to formulate aqueous and oily vehicle-based RTG crystalline suspension...

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Bibliographic Details
Main Authors: Min Seop Kim, Myoung Jin Ho, Min Yeong Joung, Yong Seok Choi, Myung Joo Kang
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Pharmaceutics
Subjects:
Rotigotine
parenteral long-acting delivery
crystalline suspension
dispersion medium
pharmacokinetics
local distribution
Online Access:https://www.mdpi.com/1999-4923/14/12/2630

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