De novo biosynthesis of antiarrhythmic alkaloid ajmaline

De novo biosynthesis of antiarrhythmic alkaloid ajmaline

Abstract The antiarrhythmic drug ajmaline is a monoterpenoid indole alkaloid (MIA) isolated from the Ayurvedic plant Rauvolfia serpentina (Indian Snakeroot). Research into the biosynthesis of ajmaline and another renowned MIA chemotherapeutic drug vinblastine has yielded pivotal advancements in the...

Full description

Bibliographic Details
Main Authors:	Jun Guo, Di Gao, Jiazhang Lian, Yang Qu
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-024-44797-z

Similar Items

Macroline, akuammiline, sarpagine, and ajmaline alkaloids from Alstonia macrophylla
by: Kam, Toh Seok, et al.
Published: (2013)

Ajmaline, Oxindole, and Cytotoxic Macroline–Akuammiline Bisindole Alkaloids from Alstonia penangiana
by: Yeap, Joanne Soon Yee, et al.
Published: (2018)

Monomorphic ventricular tachycardia during the ajmaline test
by: Onur Akpınar, et al.
Published: (2013-09-01)

De Novo Biosynthesis of Vindoline and Catharanthine in Saccharomyces cerevisiae
by: Di Gao, et al.
Published: (2022-01-01)

De novo biosynthesis of berberine and halogenated benzylisoquinoline alkaloids in Saccharomyces cerevisiae
by: Jianing Han, et al.
Published: (2023-02-01)

Biosynthesis of indole alkaloids /
by: 227831 Rahman, Atta-ur-, et al.
Published: (1983)

T-Peak to T-End Interval for Prediction of Positive Response to Ajmaline Challenge Test in Suspected Brugada Syndrome Patients
by: Mananchaya Thapanasuta, et al.
Published: (2022-12-01)

Understanding and manipulating alkaloid biosynthesis
by: Glenn, Weslee S. (Weslee Sinclair)
Published: (2014)

Alcohol acyltransferases for the biosynthesis of esters
by: Gaofei Liu, et al.
Published: (2023-06-01)

Structure-function analysis of CYP719As involved in methylenedioxy bridge-formation in the biosynthesis of benzylisoquinoline alkaloids and its de novo production
by: Xiuyu Liu, et al.
Published: (2023-02-01)

De Novo RNA Sequencing and Expression Analysis of Aconitum carmichaelii to Analyze Key Genes Involved in the Biosynthesis of Diterpene Alkaloids
by: Megha Rai, et al.
Published: (2017-12-01)

Intricate Metabolic Network for Paclitaxel Biosynthesis
by: Yuanwei Gou, et al.
Published: (2024-01-01)

ANTIARRHYTHMIC EFFECT OF PENTAMIN
by: Y. R. Sheykh-Zade, et al.
Published: (2001-02-01)

Statins and their antiarrhythmic activity
by: N. Sh. Zagidullin, et al.
Published: (1970-01-01)

Biosynthesis of plant neuroactive alkaloids treating Alzheimer’s disease
by: Quanyu Yin, et al.
Published: (2025-02-01)

Advances in the biosynthesis of naturally occurring benzylisoquinoline alkaloids
by: Wanli Zhao, et al.
Published: (2025-01-01)

An Update of the Sanguinarine and Benzophenanthridine Alkaloids’ Biosynthesis and Their Applications
by: José Ignacio Laines-Hidalgo, et al.
Published: (2022-02-01)

De novo cholesterol biosynthesis in bacteria
by: Alysha K. Lee, et al.
Published: (2023-05-01)

Maastricht antiarrhythmic drug evaluator (MANTA): A computational tool for better understanding of antiarrhythmic drugs
by: Sutanto, H, et al.
Published: (2019)

Light regulation of the biosynthesis of phenolics, terpenoids, and alkaloids in plants
by: Yongliang Liu, et al.
Published: (2023-10-01)

Biosynthesis and Biological Activities of Newly Discovered Amaryllidaceae Alkaloids
by: Seydou Ka, et al.
Published: (2020-10-01)

Opium alkaloids, biosynthesis, pharmacology and association with cancer occurrence
by: Agrataben Vadhel, et al.
Published: (2023-05-01)

Human alkaloid biosynthesis : chemical inducers of Parkinson's disease?
by: Hatzios, Stavroula K. (Stavroula-Artemis K.)
Published: (2007)

Substrate analogs to investigate alkaloid biosynthesis in Catharanthus roseus
by: McCoy, Elizabeth Ann, Ph. D. Massachusetts Institute of Technology
Published: (2009)

Aza-Tryptamine Substrates in Monoterpene Indole Alkaloid Biosynthesis
by: Lee, Hyang-Yeol, et al.
Published: (2015)

Ajmaline blocks INa and IKr without eliciting differences between Brugada syndrome patient and control human pluripotent stem cell-derived cardiac clusters
by: Duncan C. Miller, et al.
Published: (2017-12-01)

De novo production of protoberberine and benzophenanthridine alkaloids through metabolic engineering of yeast
by: Xiang Jiao, et al.
Published: (2024-10-01)

Interactions that matter: 10 Antiarrhythmic drugs
by: Aronson, J
Published: (1987)

Prediction of antiarrhythmic therapy effectiveness in children
by: L. I. Svintsova, et al.
Published: (2019-08-01)

Antiarrhythmic properties of N-Deacetyllappaconitine Hydrochloride
by: S. A. Kryzhanovskii, et al.
Published: (2022-01-01)

Metabolic Effects of Elicitors on the Biosynthesis of Tropane Alkaloids in Medicinal Plants
by: Yuru Wen, et al.
Published: (2023-08-01)

Silencing of tryptamine biosynthesis for production of nonnatural alkaloids in plant culture
by: O'Connor, Sarah Ellen, et al.
Published: (2010)

Reprogramming alkaloid biosynthesis in Catharanthus roseus : synthetic biology in plants
by: Runguphan, Weerawat
Published: (2011)

Binary Stress Induces an Increase in Indole Alkaloid Biosynthesis in Catharanthus roseus
by: Wei eZhu, et al.
Published: (2015-07-01)

Class III Antiarrhythmics and Periprocedural Torsades de Pointes
by: Cristina M. Font, MD, et al.
Published: (2023-10-01)

Improved protein glycosylation enabled heterologous biosynthesis of monoterpenoid indole alkaloids and their unnatural derivatives in yeast
by: Mohammadamin Shahsavarani, et al.
Published: (2023-06-01)

De novo biosynthesis of the hops bioactive flavonoid xanthohumol in yeast
by: Shan Yang, et al.
Published: (2024-01-01)

Phenylpropane biosynthesis and alkaloid metabolism pathways involved in resistance of Amorphophallus spp. against soft rot disease
by: Penghua Gao, et al.
Published: (2024-02-01)

De novo biosynthesis of phytohormone jasmonates in engineered yeast
by: Chengfeng Xue, et al.
Published: (2024-03-01)

Regulation of de novo nucleotide biosynthesis in cancer cells
by: Xuemei Tong
Published: (2017-03-01)